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Improving large language models (LLMs) for electronic health record (EHR) reasoning is essential for enabling accurate and generalizable clinical predictions. While LLMs excel at medical text understanding, they underperform on EHR-based…

Artificial Intelligence · Computer Science 2025-08-20 Yue Fang , Yuxin Guo , Jiaran Gao , Hongxin Ding , Xinke Jiang , Weibin Liao , Yongxin Xu , Yinghao Zhu , Zhibang Yang , Liantao Ma , Junfeng Zhao , Yasha Wang

Digital healthcare systems have enabled the collection of mass healthcare data in electronic healthcare records (EHRs), allowing artificial intelligence solutions for various healthcare prediction tasks. However, existing studies often…

Machine Learning · Computer Science 2025-08-27 Zi Cai , Yu Liu , Zhiyao Luo , Tingting Zhu

Patient representation learning refers to learning a dense mathematical representation of a patient that encodes meaningful information from Electronic Health Records (EHRs). This is generally performed using advanced deep learning methods.…

Machine Learning · Computer Science 2021-01-26 Yuqi Si , Jingcheng Du , Zhao Li , Xiaoqian Jiang , Timothy Miller , Fei Wang , W. Jim Zheng , Kirk Roberts

Multimodal electronic health record (EHR) data are widely used in clinical applications. Conventional methods usually assume that each sample (patient) is associated with the unified observed modalities, and all modalities are available for…

Machine Learning · Computer Science 2022-11-01 Chaohe Zhang , Xu Chu , Liantao Ma , Yinghao Zhu , Yasha Wang , Jiangtao Wang , Junfeng Zhao

Few-shot learning aims to adapt knowledge learned from previous tasks to novel tasks with only a limited amount of labeled data. Research literature on few-shot learning exhibits great diversity, while different algorithms often excel at…

Computer Vision and Pattern Recognition · Computer Science 2021-09-14 Chi Zhang , Henghui Ding , Guosheng Lin , Ruibo Li , Changhu Wang , Chunhua Shen

Motivation: Predicting the drug-target interaction is crucial for drug discovery as well as drug repurposing. Machine learning is commonly used in drug-target affinity (DTA) problem. However, machine learning model faces the cold-start…

Biomolecules · Quantitative Biology 2022-02-03 Tri Minh Nguyen , Thin Nguyen , Truyen Tran

Clinical trials are essential for drug development but often suffer from expensive, inaccurate and insufficient patient recruitment. The core problem of patient-trial matching is to find qualified patients for a trial, where patient…

Artificial Intelligence · Computer Science 2021-04-13 Xingyao Zhang , Cao Xiao , Lucas M. Glass , Jimeng Sun

Despite recent significant advancements in Handwritten Document Recognition (HDR), the efficient and accurate recognition of text against complex backgrounds, diverse handwriting styles, and varying document layouts remains a practical…

Computer Vision and Pattern Recognition · Computer Science 2025-01-23 Wenhao Gu , Li Gu , Ziqiang Wang , Ching Yee Suen , Yang Wang

Background Predicting mortality and resource utilization from electronic health records (EHRs) is challenging yet crucial for optimizing patient outcomes and managing costs in intensive care unit (ICU). Existing approaches predominantly…

Computation and Language · Computer Science 2025-08-29 Yucheng Ruan , Xiang Lan , Daniel J. Tan , Hairil Rizal Abdullah , Mengling Feng

The significant advancements in large language models (LLMs) give rise to a promising research direction, i.e., leveraging LLMs as recommenders (LLMRec). The efficacy of LLMRec arises from the open-world knowledge and reasoning capabilities…

Information Retrieval · Computer Science 2024-07-02 Hangyu Wang , Jianghao Lin , Bo Chen , Yang Yang , Ruiming Tang , Weinan Zhang , Yong Yu

We investigate the learning of quantitative structure activity relationships (QSARs) as a case-study of meta-learning. This application area is of the highest societal importance, as it is a key step in the development of new medicines. The…

Artificial Intelligence · Computer Science 2017-09-13 Ivan Olier , Noureddin Sadawi , G. Richard Bickerton , Joaquin Vanschoren , Crina Grosan , Larisa Soldatova , Ross D. King

Clinical decision support systems are software tools that help clinicians to make medical decisions. However, their acceptance by clinicians is usually rather low. A known problem is that they often require clinicians to manually enter lots…

Artificial Intelligence · Computer Science 2023-09-20 Jean-Baptiste Lamy , Abdelmalek Mouazer , Karima Sedki , Sophie Dubois , Hector Falcoff

Despite its astounding success in learning deeper multi-dimensional data, the performance of deep learning declines on new unseen tasks mainly due to its focus on same-distribution prediction. Moreover, deep learning is notorious for poor…

Machine Learning · Computer Science 2023-03-15 Hassan Gharoun , Fereshteh Momenifar , Fang Chen , Amir H. Gandomi

Federated recommendation system usually trains a global model on the server without direct access to users' private data on their own devices. However, this separation of the recommendation model and users' private data poses a challenge in…

Information Retrieval · Computer Science 2024-02-27 Chunxu Zhang , Guodong Long , Tianyi Zhou , Zijian Zhang , Peng Yan , Bo Yang

Combinatorial medication recommendation(CMR) is a fundamental task of healthcare, which offers opportunities for clinical physicians to provide more precise prescriptions for patients with intricate health conditions, particularly in the…

Artificial Intelligence · Computer Science 2025-01-14 Jie Tan , Yu Rong , Kangfei Zhao , Tian Bian , Tingyang Xu , Junzhou Huang , Hong Cheng , Helen Meng

Recent development in data-driven decision science has seen great advances in individualized decision making. Given data with individual covariates, treatment assignments and outcomes, researchers can search for the optimal individualized…

Methodology · Statistics 2021-12-16 Weibin Mo , Yufeng Liu

Objectives: Electronic health records (EHRs) are only a first step in capturing and utilizing health-related data - the challenge is turning that data into useful information. Furthermore, EHRs are increasingly likely to include data…

Artificial Intelligence · Computer Science 2012-08-20 Casey Bennett , Tom Doub , Rebecca Selove

Electronic phenotyping is the task of ascertaining whether an individual has a medical condition of interest by analyzing their medical record and is foundational in clinical informatics. Increasingly, electronic phenotyping is performed…

Machine Learning · Statistics 2019-01-08 Daisy Yi Ding , Chloé Simpson , Stephen Pfohl , Dave C. Kale , Kenneth Jung , Nigam H. Shah

The ability of large language models (LLMs) to follow natural language instructions with human-level fluency suggests many opportunities in healthcare to reduce administrative burden and improve quality of care. However, evaluating LLMs on…

Over an extensive duration, administrators and clinicians have endeavoured to predict Emergency Department (ED) visits with precision, aiming to optimise resource distribution. Despite the proliferation of diverse AI-driven models tailored…

Machine Learning · Computer Science 2025-11-11 Mehdi Neshat , Michael Phipps , Nikhil Jha , Danial Khojasteh , Michael Tong , Amir Gandomi