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Finding an effective medical treatment often requires a search by trial and error. Making this search more efficient by minimizing the number of unnecessary trials could lower both costs and patient suffering. We formalize this problem as…

Machine Learning · Computer Science 2021-02-18 Samuel Håkansson , Viktor Lindblom , Omer Gottesman , Fredrik D. Johansson

In this article, we consider the problem of simultaneous testing of hypotheses when the individual test statistics are not necessarily independent. Specifically, we consider the problem of simultaneous testing of point null hypotheses…

Statistics Theory · Mathematics 2018-07-17 Prasenjit Ghosh , Arijit Chakrabarti

This paper studies policy learning for continuous treatments from observational data. Continuous treatments present more significant challenges than discrete ones because population welfare may need nonparametric estimation, and policy…

Econometrics · Economics 2025-12-02 Chunrong Ai , Yue Fang , Haitian Xie

In the search for genetic factors that are associated with complex heritable human traits, considerable attention is now being focused on rare variants that individually have small effects. In response, numerous recent papers have proposed…

Methodology · Statistics 2014-09-10 Andriy Derkach , Jerry F. Lawless , Lei Sun

The outbreak of the novel coronavirus (COVID-19) is unfolding as a major international crisis whose influence extends to every aspect of our daily lives. Effective testing allows infected individuals to be quarantined, thus reducing the…

Machine Learning · Computer Science 2020-07-28 Rahul Singh , Fang Liu , Ness B. Shroff

We consider the problem of group testing with sum observations and noiseless answers, in which we aim to locate multiple objects by querying the number of objects in each of a sequence of chosen sets. We study a probabilistic setting with…

Information Theory · Computer Science 2015-09-24 Weidong Han , Purnima Rajan , Peter I. Frazier , Bruno M. Jedynak

A major public health issue is the growing resistance of bacteria to antibiotics. An important part of the needed response is the discovery and development of new antimicrobial strategies. These require the screening of potential new drugs,…

Applications · Statistics 2026-02-19 Byran Smucker , Benjamin Brennan , Emily Rego , Meng Wu , Zhihong Lin , Brian Ahmer , Blake Peterson

We study the problem of identifying defective units in a finite population of \( n \) units, where each unit \( i \) is independently defective with known probability \( p_i \). This setting is referred to as the \emph{Generalized Group…

Statistics Theory · Mathematics 2025-06-23 Yaakov Malinovsky , Viktor Skorniakov

Recently, a new testing approach for response-adaptive clinical trials was proposed based on the allocation probabilities (AP) rather than the outcome data. While original work on the AP test focused on binary and normal endpoints and…

Methodology · Statistics 2026-05-11 Stina Zetterstrom , David S. Robertson , Thomas Jaki , Sofía S. Villar

Motivated by our collaboration with a major refugee resettlement agency in the U.S., we study a dynamic matching problem where each new arrival (a refugee case) must be matched immediately and irrevocably to one of the static resources (a…

Data Structures and Algorithms · Computer Science 2025-07-03 Kirk Bansak , Soonbong Lee , Vahideh Manshadi , Rad Niazadeh , Elisabeth Paulson

In big data analysis, a simple task such as linear regression can become very challenging as the variable dimension $p$ grows. As a result, variable screening is inevitable in many scientific studies. In recent years, randomized algorithms…

Methodology · Statistics 2019-02-13 Yu-Hsiang Cheng , Tzee-Ming Huang , Su-Yun Huang

Dynamic treatment regimes or policies are a sequence of decision functions over multiple stages that are tailored to individual features. One important class of treatment policies in practice, namely multi-stage stationary treatment…

Machine Learning · Statistics 2025-01-09 Daiqi Gao , Yufeng Liu , Donglin Zeng

This paper studies algorithmic decision-making in the presence of strategic individual behaviors, where an ML model is used to make decisions about human agents and the latter can adapt their behavior strategically to improve their future…

Artificial Intelligence · Computer Science 2025-08-22 Tian Xie , Xueru Zhang

Imagine a patient in critical condition. What and when should be measured to forecast detrimental events, especially under the budget constraints? We answer this question by deep reinforcement learning (RL) that jointly minimizes the…

Machine Learning · Computer Science 2019-06-11 Chun-Hao Chang , Mingjie Mai , Anna Goldenberg

Large-scale multiple testing under static factor models is widely used to detect sparse signals in high-dimensional data. However, static factor models are arguably too stringent because they ignore serial correlation, which seriously…

Statistics Theory · Mathematics 2025-04-04 Xinxin Yang , Lilun Du

This study employs gamified experiments to investigate and refine the Schelling Model of Segregation, a framework that demonstrates how individual preferences can lead to systemic segregation. Using a movement selection algorithm derived…

Physics and Society · Physics 2025-01-15 Aleix Nicolás Olivé , Luce Prignano , Dimitri Marinelli , Emanuele Cozzo

We propose a novel testing and containment strategy in order to contain the spread of SARS-CoV2 while permitting large parts of the population to resume social and economic activity. Our approach recognises the fact that testing capacities…

Populations and Evolution · Quantitative Biology 2020-04-29 Jakob Jonnerby , Philip Lazos , Edwin Lock , Francisco Marmolejo-Cossío , C. Bronk Ramsey , Meghana Shukla , Divya Sridhar

Regulatory approval of products in high-stakes domains such as drug development requires statistical evidence of safety and efficacy through large-scale randomized controlled trials. However, the high financial cost of these trials may…

Computer Science and Game Theory · Computer Science 2026-05-08 Ander Artola Velasco , Stratis Tsirtsis , Manuel Gomez-Rodriguez

Bayesian optimization (BO) algorithms try to optimize an unknown function that is expensive to evaluate using minimum number of evaluations/experiments. Most of the proposed algorithms in BO are sequential, where only one experiment is…

Machine Learning · Computer Science 2011-10-18 Javad Azimi , Ali Jalali , Xiaoli Fern

We study the canonical problem of maximizing a stochastic submodular function subject to a cardinality constraint, where the goal is to select a subset from a ground set of items with uncertain individual performances to maximize their…

Data Structures and Algorithms · Computer Science 2019-05-10 Shreyas Sekar , Milan Vojnovic , Se-Young Yun
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