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Clinical EEG interpretation requires reasoning over full EEG sessions and integrating signal patterns with clinical context. Existing EEG foundation models are largely designed for short-window decoding and do not incorporate clinical…

Artificial Intelligence · Computer Science 2026-05-12 Peng Cao , Ali Mirzazadeh , Jong Woo Lee , Aleksandar Videnovic , Dina Katabi

Recent advancements for large-scale pre-training with neural signals such as electroencephalogram (EEG) have shown promising results, significantly boosting the development of brain-computer interfaces (BCIs) and healthcare. However, these…

Signal Processing · Electrical Eng. & Systems 2025-03-21 Wei-Bang Jiang , Yansen Wang , Bao-Liang Lu , Dongsheng Li

Multimodal language modeling has enabled breakthroughs for representation learning, yet remains unexplored in the realm of functional brain data for clinical phenotyping. This paper pioneers EEG-language models (ELMs) trained on clinical…

Signal Processing · Electrical Eng. & Systems 2025-08-12 Sam Gijsen , Kerstin Ritter

Recent advances in Large Language Models (LLMs) have led to remarkable progresses in medical consultation. However, existing medical LLMs overlook the essential role of Electronic Health Records (EHR) and focus primarily on diagnosis…

Artificial Intelligence · Computer Science 2025-06-26 Weijieying Ren , Tianxiang Zhao , Lei Wang , Tianchun Wang , Vasant Honavar

Recent advances have increasingly applied large language models (LLMs) to electrocardiogram (ECG) interpretation, giving rise to Electrocardiogram-Language Models (ELMs). Conditioned on an ECG and a textual query, an ELM autoregressively…

Artificial Intelligence · Computer Science 2025-05-27 William Han , Chaojing Duan , Zhepeng Cen , Yihang Yao , Xiaoyu Song , Atharva Mhaskar , Dylan Leong , Michael A. Rosenberg , Emerson Liu , Ding Zhao

While recent multimodal large language models (MLLMs) have advanced automated ECG interpretation, they still face two key limitations: (1) insufficient multimodal synergy between time series signals and visual ECG representations, and (2)…

Computation and Language · Computer Science 2025-10-21 Xiang Lan , Feng Wu , Kai He , Qinghao Zhao , Shenda Hong , Mengling Feng

Electrocardiogram (ECG) is the primary non-invasive diagnostic tool for monitoring cardiac conditions and is crucial in assisting clinicians. Recent studies have concentrated on classifying cardiac conditions using ECG data but have…

Computation and Language · Computer Science 2025-07-09 Zhongwei Wan , Che Liu , Xin Wang , Chaofan Tao , Hui Shen , Jing Xiong , Rossella Arcucci , Huaxiu Yao , Mi Zhang

Electroencephalography (EEG) interpretation using multimodal large language models (MLLMs) offers a novel approach for analyzing brain signals. However, the complex nature of brain activity introduces critical challenges: EEG signals…

Signal Processing · Electrical Eng. & Systems 2025-10-02 Ziyi Zeng , Zhenyang Cai , Yixi Cai , Xidong Wang , Junying Chen , Rongsheng Wang , Yipeng Liu , Siqi Cai , Benyou Wang , Zhiguo Zhang , Haizhou Li

The integration of multimodal Electronic Health Records (EHR) data has significantly improved clinical predictive capabilities. Leveraging clinical notes and multivariate time-series EHR, existing models often lack the medical context…

Artificial Intelligence · Computer Science 2024-02-13 Yinghao Zhu , Changyu Ren , Shiyun Xie , Shukai Liu , Hangyuan Ji , Zixiang Wang , Tao Sun , Long He , Zhoujun Li , Xi Zhu , Chengwei Pan

Text embeddings have become an essential part of a variety of language applications. However, methods for interpreting, exploring and reversing embedding spaces are limited, reducing transparency and precluding potentially valuable…

Computation and Language · Computer Science 2026-01-27 Brian Ondov , Chia-Hsuan Chang , Yujia Zhou , Mauro Giuffrè , Hua Xu

Cardiac signals, such as the electrocardiogram, convey a significant amount of information about the health status of a patient which is typically summarized by a clinician in the form of a clinical report, a cumbersome process that is…

Computation and Language · Computer Science 2021-03-23 Dani Kiyasseh , Tingting Zhu , David Clifton

The current electroencephalogram (EEG) based deep learning models are typically designed for specific datasets and applications in brain-computer interaction (BCI), limiting the scale of the models and thus diminishing their perceptual…

Machine Learning · Computer Science 2024-06-06 Wei-Bang Jiang , Li-Ming Zhao , Bao-Liang Lu

Electrocardiograms (ECG) are electrical recordings of the heart that are critical for diagnosing cardiovascular conditions. ECG language models (ELMs) have recently emerged as a promising framework for ECG classification accompanied by…

Existing benchmarks for evaluating the clinical reasoning capabilities of large language models (LLMs) often lack a clear definition of "clinical reasoning" as a construct, fail to capture the full breadth of interdependent tasks within a…

Large Language Models (LLMs) have been shown to encode clinical knowledge. Many evaluations, however, rely on structured question-answer benchmarks, overlooking critical challenges of interpreting and reasoning about unstructured clinical…

Computation and Language · Computer Science 2026-04-01 Meghal Dani , Muthu Jeyanthi Prakash , Filip Rosa , Zeynep Akata , Stefanie Liebe

Electroencephalography foundation models (EEG-FMs) have advanced brain signal analysis, but the lack of standardized evaluation benchmarks impedes model comparison and scientific progress. Current evaluations rely on inconsistent protocols…

Signal Processing · Electrical Eng. & Systems 2026-02-16 Wei Xiong , Jiangtong Li , Jie Li , Kun Zhu , Changjun Jiang

Electroencephalography (EEG), with its broad range of applications, necessitates models that can generalize effectively across various tasks and datasets. Large EEG Models (LEMs) address this by pretraining encoder-centric architectures on…

Machine Learning · Computer Science 2025-09-29 Chenyu Liu , Yuqiu Deng , Tianyu Liu , Jinan Zhou , Xinliang Zhou , Ziyu Jia , Yi Ding

Scalable and generalizable analysis of brain activity is essential for advancing both clinical diagnostics and cognitive research. Electroencephalography (EEG), a non-invasive modality with high temporal resolution, has been widely used for…

Machine Learning · Computer Science 2025-12-01 Sha Zhao , Mingyi Peng , Haiteng Jiang , Tao Li , Shijian Li , Gang Pan

Europe's healthcare systems require enhanced interoperability and digitalization, driving a demand for innovative solutions to process legacy clinical data. This paper presents the results of our project, which aims to leverage Large…

Computation and Language · Computer Science 2025-07-09 Aynur Guluzade , Naguib Heiba , Zeyd Boukhers , Florim Hamiti , Jahid Hasan Polash , Yehya Mohamad , Carlos A Velasco

Deep Learning has revolutionized various fields, including Computer Vision, Natural Language Processing, as well as Biomedical research. Within the field of neuroscience, specifically in electrophysiological neuroimaging, researchers are…

Machine Learning · Computer Science 2022-04-14 Dung Truong , Manisha Sinha , Kannan Umadevi Venkataraju , Michael Milham , Arnaud Delorme
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