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Objectives We aimed to evaluate the diagnostic performance of deep learning (DL)-based radiomics models for the noninvasive prediction of isocitrate dehydrogenase (IDH) mutation and 1p/19q co-deletion status in glioma patients using MRI…
Variational autoencoder (VAE) and generative adversarial networks (GAN) have found widespread applications in clustering and have achieved significant success. However, the potential of these approaches may be limited due to VAE's mediocre…
This work develops a novel set of algorithms, alternating Gradient Descent (GD) and minimization for MRI (altGDmin-MRI1 and altGDmin-MRI2), for accelerated dynamic MRI by assuming an approximate low-rank (LR) model on the matrix formed by…
Liver cancer is a leading cause of cancer-related mortality worldwide, with its high genetic heterogeneity complicating diagnosis and treatment. This study introduces DLSOM, a deep learning framework utilizing stacked autoencoders to…
The parsimonious Gaussian mixture models, which exploit an eigenvalue decomposition of the group covariance matrices of the Gaussian mixture, have shown their success in particular in cluster analysis. Their estimation is in general…
Block Diffusion Models (BDMs) support parallel generation, flexible-length output, and KV caching, making them promising for efficient document parsing. However, existing BDMs bind denoising and cache commitment to fixed block boundaries:…
In the genomic era, the identification of gene signatures associated with disease is of significant interest. Such signatures are often used to predict clinical outcomes in new patients and aid clinical decision-making. However, recent…
Diffusion language models (DLMs) have recently emerged as a promising alternative to autoregressive (AR) approaches, enabling parallel token generation beyond a rigid left-to-right order. Despite growing empirical success, the theoretical…
Large language models (LLMs) have demonstrated remarkable capabilities across various tasks. However, their widespread application is hindered by the resource-intensive decoding process. To address this challenge, current approaches have…
Clustering is a widely deployed unsupervised learning tool. Model-based clustering is a flexible framework to tackle data heterogeneity when the clusters have different shapes. Likelihood-based inference for mixture distributions often…
Protein inverse folding is a fundamental problem in bioinformatics, aiming to recover the amino acid sequences from a given protein backbone structure. Despite the success of existing methods, they struggle to fully capture the intricate…
The rapidly emerging field of computational pathology has the potential to enable objective diagnosis, therapeutic response prediction and identification of new morphological features of clinical relevance. However, deep learning-based…
Two challenging problems in the clinical study of cancer are the characterization of cancer subtypes and the classification of individual patients according to those subtypes. Statistical approaches addressing these problems are hampered by…
In this paper, we introduce Adaptive Cluster Lasso(ACL) method for variable selection in high dimensional sparse regression models with strongly correlated variables. To handle correlated variables, the concept of clustering or grouping…
There is a rich literature on clustering functional data with applications to time-series modeling, trajectory data, and even spatio-temporal applications. However, existing methods routinely perform global clustering that enforces…
Background: Accurate segmentation of diffuse large B-cell lymphoma (DLBCL) lesions is challenging due to their complex patterns in medical imaging. Objective: This study aims to develop a precise segmentation method for DLBCL using…
This paper features convolutional neural networks defined on hypercomplex algebras applied to classify lymphocytes in blood smear digital microscopic images. Such classification is helpful for the diagnosis of acute lymphoblast leukemia…
Context graphs are essential for modern AI applications including question answering, pattern discovery, and data analysis. Building accurate context graphs from structured databases requires inferring join relationships between entities.…
Machine learning for tabular data remains constrained by poor schema generalization, a challenge rooted in the lack of semantic understanding of structured variables. This challenge is particularly acute in domains like clinical medicine,…
Model-based clustering techniques have been widely applied to various application areas, while most studies focus on canonical mixtures with unique component distribution form. However, this strict assumption is often hard to satisfy. In…