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Genomic studies face a vast hypothesis space, while interventions such as gene perturbations remain costly and time-consuming. To accelerate such experiments, gene perturbation models predict the transcriptional outcome of interventions.…

Quantitative Methods · Quantitative Biology 2025-10-21 George Panagopoulos , Johannes F. Lutzeyer , Sofiane Ennadir , Michalis Vazirgiannis , Jun Pang

We introduce LatentTimePFN (LaT-PFN), a foundational Time Series model with a strong embedding space that enables zero-shot forecasting. To achieve this, we perform in-context learning in latent space utilizing a novel integration of the…

Machine Learning · Computer Science 2024-05-24 Stijn Verdenius , Andrea Zerio , Roy L. M. Wang

TabPFN has recently gained attention as a foundation model for tabular datasets, achieving strong performance by leveraging in-context learning on synthetic data. However, we find that TabPFN is vulnerable to label shift, often overfitting…

Machine Learning · Computer Science 2026-05-26 Seunghan Lee

Modeling event sequences of multiple event types with marked temporal point processes (MTPPs) provides a principled way to uncover governing dynamical rules and predict future events. Current neural network approaches to MTPP inference rely…

Machine Learning · Computer Science 2026-03-02 David Berghaus , Patrick Seifner , Kostadin Cvejoski , César Ojeda , Ramsés J. Sánchez

Tabular foundation models based on pretrained prior-data fitted networks~(PFNs) have shown strong generalization on diverse tabular tasks, but they are typically designed for \emph{non-strategic} settings where data distributions are…

The human brain is the gold standard of adaptive learning. It not only can learn and benefit from experience, but also can adapt to new situations. In contrast, deep neural networks only learn one sophisticated but fixed mapping from inputs…

Computer Vision and Pattern Recognition · Computer Science 2021-03-18 Shixian Wen , Amanda Rios , Yunhao Ge , Laurent Itti

Building Virtual Cells that can accurately simulate cellular responses to perturbations is a long-standing goal in systems biology. A fundamental challenge is that high-throughput single-cell sequencing is destructive: the same cell cannot…

Machine Learning · Computer Science 2026-02-24 Xinyu Yuan , Xixian Liu , Ya Shi Zhang , Zuobai Zhang , Hongyu Guo , Jian Tang

The diversity of time series applications and scarcity of domain-specific data highlight the need for time-series models with strong few-shot learning capabilities. In this work, we propose a novel training scheme and a transformer-based…

Machine Learning · Computer Science 2025-02-25 Ege Onur Taga , M. Emrullah Ildiz , Samet Oymak

Causal structure learning (CSL) refers to the task of learning causal relationships from data. Advances in CSL now allow learning of causal graphs in diverse application domains, which has the potential to facilitate data-driven causal…

Machine Learning · Statistics 2024-07-09 Luka Kovačević , Izzy Newsham , Sach Mukherjee , John Whittaker

Causal discovery is fundamental for multiple scientific domains, yet extracting causal information from real world data remains a significant challenge. Given the recent success on real data, we investigate whether TabPFN, a…

Machine Learning · Computer Science 2025-11-11 Omar Swelam , Lennart Purucker , Jake Robertson , Hanne Raum , Joschka Boedecker , Frank Hutter

Hollmann et al. (Nature 637 (2025) 319-326) recently introduced TabPFN, a transformer-based deep learning model for regression and classification on tabular data, which they claim "outperforms all previous methods on datasets with up to…

Machine Learning · Computer Science 2025-12-01 Qiong Zhang , Yan Shuo Tan , Qinglong Tian , Pengfei Li

Networks (graphs) in psychology are often restricted to settings without interventions. Here we consider a framework borrowed from biology that involves multiple interventions from different contexts (observations and experiments) in a…

Methodology · Statistics 2024-09-23 Lourens Waldorp , Jolanda Kossakowski , Han L. J. van der Maas

Causal inference, estimating causal effects from observational data, is a fundamental tool in many disciplines. Of particular importance across a variety of domains is the continuous treatment setting, where the variable of intervention has…

Machine Learning · Computer Science 2026-05-15 Christopher Stith , Medha Barath , Vahid Balazadeh , Jesse C. Cresswell , Rahul G. Krishnan

TabPFN [Hollmann et al., 2023], a Transformer model pretrained to perform in-context learning on fresh tabular classification problems, was presented at the last ICLR conference. To better understand its behavior, we treat it as a black-box…

Machine Learning · Computer Science 2025-02-14 Calvin McCarter

In drug discovery, mapping interactions between genes within cellular systems is a crucial early step. Such maps are not only foundational for understanding the molecular mechanisms underlying disease biology but also pivotal for…

Identifying variables responsible for changes to a biological system enables applications in drug target discovery and cell engineering. Given a pair of observational and interventional datasets, the goal is to isolate the subset of…

Machine Learning · Computer Science 2025-06-02 Menghua Wu , Umesh Padia , Sean H. Murphy , Regina Barzilay , Tommi Jaakkola

Traditional methods for tabular classification usually rely on supervised learning from scratch, which requires extensive training data to determine model parameters. However, a novel approach called Prior-Data Fitted Networks (TabPFN) has…

Machine Learning · Computer Science 2024-06-12 Quangao Liu , Wei Yang , Chen Liang , Longlong Pang , Zhuozhang Zou

In engineering design, navigating complex decision-making landscapes demands a thorough exploration of the design, performance, and constraint spaces, often impeded by resource-intensive simulations. Data-driven methods can mitigate this…

Computational Engineering, Finance, and Science · Computer Science 2024-01-17 Cyril Picard , Faez Ahmed

State-of-the-art data stream mining has long drawn from ensembles of the Very Fast Decision Tree, a seminal algorithm honored with the 2015 KDD Test-of-Time Award. However, the emergence of large tabular models, i.e., transformers designed…

Machine Learning · Computer Science 2025-12-16 Afonso Lourenço , João Gama , Eric P. Xing , Goreti Marreiros

Tabular classification has traditionally relied on supervised algorithms, which estimate the parameters of a prediction model using its training data. Recently, Prior-Data Fitted Networks (PFNs) such as TabPFN have successfully learned to…

Machine Learning · Computer Science 2023-11-20 Benjamin Feuer , Chinmay Hegde , Niv Cohen