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Proton pencil beam scanning (PBS) treatment planning for head & neck (H&N) cancers involves numerous conflicting objectives, requiring iterative objective parameter adjustments to balance multiple clinical goals. We propose a…

Artificial Intelligence · Computer Science 2025-09-16 Qingqing Wang , Liqiang Xiao , Chang Chang

Convex optimization encompasses a wide range of optimization problems that contain many efficiently solvable subclasses. Interior point methods are currently the state-of-the-art approach for solving such problems, particularly effective…

Optimization and Control · Mathematics 2025-03-28 Andreas Klingler , Tim Netzer

Multi-Objective Optimization (MOO) is an important problem in real-world applications. However, for a non-trivial problem, no single solution exists that can optimize all the objectives simultaneously. In a typical MOO problem, the goal is…

Machine Learning · Computer Science 2024-09-17 Zhang Haishan , Diptesh Das , Koji Tsuda

Matrix-based optimizers have demonstrated immense potential in training Large Language Models (LLMs), however, designing an ideal optimizer remains a formidable challenge. A superior optimizer must satisfy three core desiderata: efficiency,…

Machine Learning · Computer Science 2026-05-06 Jinghui Yuan , Jiaxuan Zou , Shuo Wang , Yong Liu , Feiping Nie

Role-playing agents (RPAs) require balancing multiple objectives, such as instruction following, persona consistency, and stylistic fidelity, which are not always perfectly aligned across different dimensions. While prior work has primarily…

Computation and Language · Computer Science 2026-04-23 Chonghua Liao , Ke Wang , Yuchuan Wu , Ruoran Li , Fei Huang , Yongbin Li

Purpose: Current inverse planning methods for IMRT are limited because they are not designed to explore the trade-offs between the competing objectives between the tumor and normal tissues. Our goal was to develop an efficient…

Medical Physics · Physics 2015-06-04 Clay Holdsworth , Minsun Kim , Jay Liao , Mark H Phillips

The direct parametrisation method for invariant manifold is a model-order reduction technique that can be applied to nonlinear systems described by PDEs and discretised e.g. with a finite element procedure in order to derive efficient…

Numerical Analysis · Mathematics 2024-03-19 Alessandra Vizzaccaro , Giorgio Gobat , Attilio Frangi , Cyril Touzé

This work pioneers regret analysis of risk-sensitive reinforcement learning in partially observable environments with hindsight observation, addressing a gap in theoretical exploration. We introduce a novel formulation that integrates…

Machine Learning · Computer Science 2024-02-29 Tonghe Zhang , Yu Chen , Longbo Huang

Network estimation from multi-variate point process or time series data is a problem of fundamental importance. Prior work has focused on parametric approaches that require a known parametric model, which makes estimation procedures less…

Machine Learning · Statistics 2021-06-30 Yue Gao , Garvesh Raskutti

This paper deals with discrete topology optimization and describes the modification of a single-objective algorithm into its multi-objective counterpart. The result is a significant increase in the optimization speed and quality of the…

Neural and Evolutionary Computing · Computer Science 2025-03-13 Petr Kadlec , Miloslav Capek

End-to-end deep learning has achieved impressive results but remains limited by its reliance on large labeled datasets, poor generalization to unseen scenarios, and growing computational demands. In contrast, classical optimization methods…

Machine Learning · Computer Science 2025-08-19 Gal Lifshitz , Shahar Zuler , Ori Fouks , Dan Raviv

In partially observable (PO) environments, deep reinforcement learning (RL) agents often suffer from unsatisfactory performance, since two problems need to be tackled together: how to extract information from the raw observations to solve…

Machine Learning · Computer Science 2019-12-25 Dongqi Han , Kenji Doya , Jun Tani

Optimization of frame structures is formulated as a~non-convex optimization problem, which is currently solved to local optimality. In this contribution, we investigate four optimization approaches: (i) general non-linear optimization, (ii)…

Optimization and Control · Mathematics 2019-09-17 Marek Tyburec , Jan Zeman , Martin Kružík , Didier Henrion

In this paper, we explore the merits of various algorithms for polynomial optimization problems, focusing on alternatives to sum of squares programming. While we refer to advantages and disadvantages of Quantifier Elimination, Reformulation…

Optimization and Control · Mathematics 2015-01-15 Reza Kamyar , Matthew Peet

We propose a new learning-based approach to solve ill-posed inverse problems in imaging. We address the case where ground truth training samples are rare and the problem is severely ill-posed - both because of the underlying physics and…

Computer Vision and Pattern Recognition · Computer Science 2018-12-07 Sidharth Gupta , Konik Kothari , Maarten V. de Hoop , Ivan Dokmanić

Consider convex optimization problems subject to a large number of constraints. We focus on stochastic problems in which the objective takes the form of expected values and the feasible set is the intersection of a large number of convex…

Machine Learning · Statistics 2015-11-13 Mengdi Wang , Yichen Chen , Jialin Liu , Yuantao Gu

Multi-objective combinatorial optimization problems (MOCOPs), one type of complex optimization problems, widely exist in various real applications. Although meta-heuristics have been successfully applied to address MOCOPs, the calculation…

Machine Learning · Computer Science 2022-04-27 Le-yang Gao , Rui Wang , Chuang Liu , Zhao-hong Jia

This work demonstrates a methodology for using deep learning to discover simple, practical criteria for classifying matrices based on abstract algebraic properties. By combining a high-performance neural network with explainable AI (XAI)…

Machine Learning · Computer Science 2025-07-31 Leandro Farina , Sergey Korotov

The performance of modern machine learning algorithms depends upon the selection of a set of hyperparameters. Common examples of hyperparameters are learning rate and the number of layers in a dense neural network. Auto-ML is a branch of…

Machine Learning · Computer Science 2024-01-01 Joshua Inman , Tanmay Khandait , Giulia Pedrielli , Lalitha Sankar

The optimization of large language models (LLMs) remains a critical challenge, particularly as model scaling exacerbates sensitivity to algorithmic imprecision and training instability. Recent advances in optimizers have improved…

Machine Learning · Computer Science 2025-11-26 Wei He , Kai Han , Hang Zhou , Hanting Chen , Zhicheng Liu , Xinghao Chen , Yunhe Wang