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Fossil DNA preservation varies with depositional environments and diagenesis, producing fragments of heterogeneous origins and degradation states. We use first-principles biomolecular analysis to classify fossil molecular environments into…

Biomolecules · Quantitative Biology 2026-03-26 Wan-Qian Zhao , Shu-Jie Zhang , Zhan-Yong Guo , Mei-Jun Li

Indefinite similarity measures can be frequently found in bio-informatics by means of alignment scores, but are also common in other fields like shape measures in image retrieval. Lacking an underlying vector space, the data are given as…

Machine Learning · Computer Science 2016-04-11 Frank-Michael Schleif , Andrej Gisbrecht , Peter Tino

Matrix factorization (MF) is a simple collaborative filtering technique that achieves superior recommendation accuracy by decomposing the user-item interaction matrix into user and item latent matrices. Because the model typically learns…

Information Retrieval · Computer Science 2024-03-11 Kai Sugahara , Kazushi Okamoto

FM-indexes are a crucial data structure in DNA alignment, for example, but searching with them usually takes at least one random access per character in the query pattern. Ferragina and Fischer observed in 2007 that word-based indexes often…

Data Structures and Algorithms · Computer Science 2023-05-11 Aaron Hong , Marco Oliva , Dominik Köppl , Hideo Bannai , Christina Boucher , Travis Gagie

Various model-based diagnosis scenarios require the computation of most preferred fault explanations. Existing algorithms that are sound (i.e., output only actual fault explanations) and complete (i.e., can return all explanations),…

Artificial Intelligence · Computer Science 2022-02-22 Patrick Rodler

Bloom filters are widely used data structures that compactly represent sets of elements. Querying a Bloom filter reveals if an element is not included in the underlying set or is included with a certain error rate. This membership testing…

Databases · Computer Science 2022-08-08 Angjela Davitkova , Damjan Gjurovski , Sebastian Michel

The amount of data coming from different sources such as IoT-sensors, social networks, cellular networks, has increased exponentially during the last few years. Probabilistic Data Structures (PDS) are efficient alternatives to deterministic…

Data Structures and Algorithms · Computer Science 2022-11-02 Remy Scholler , Jean-Francois Couchot , Oumaima Alaoui-Ismaili , Denis Renaud , Eric Ballot

Analysis of entire programs as a single unit, or whole-program analysis, involves propagation of large amounts of information through the control flow of the program. This is especially true for pointer analysis, where, unless significant…

Data Structures and Algorithms · Computer Science 2025-10-28 Anamitra Ghorui , Uday P. Khedker

There is a plethora of data structures, algorithms, and frameworks dealing with major data-stream problems like estimating the frequency of items, answering set membership, association and multiplicity queries, and several other statistics…

Data Structures and Algorithms · Computer Science 2021-06-24 Anes Abdennebi , Kamer Kaya

Modern deep learning heavily depends on adaptive optimizers such as Adam and its variants, which are renowned for their capacity to handle model scaling and streamline hyperparameter tuning. However, these algorithms typically experience…

Machine Learning · Computer Science 2024-10-18 Son Nguyen , Lizhang Chen , Bo Liu , Qiang Liu

Inspired by the fruit-fly olfactory circuit, the Fly Bloom Filter [Dasgupta et al., 2018] is able to efficiently summarize the data with a single pass and has been used for novelty detection. We propose a new classifier (for binary and…

Machine Learning · Computer Science 2020-08-21 Kaushik Sinha , Parikshit Ram

Protein function and dynamics are closely related to its sequence and structure. However prediction of protein function and dynamics from its sequence and structure is still a fundamental challenge in molecular biology. Protein…

Biomolecules · Quantitative Biology 2015-10-06 Zixuan Cang , Lin Mu , Kedi Wu , Kristopher Opron , Kelin Xia , Guo-Wei Wei

Molecular dynamics simulations yield large amounts of trajectory data. For their durable storage and accessibility an efficient compression algorithm is paramount. State of the art domain-specific algorithms combine quantization, Huffman…

Distributed, Parallel, and Cluster Computing · Computer Science 2016-01-13 Jan Huwald , Stephan Richter , Peter Dittrich

The ever-increasing data scale of user-item interactions makes it challenging for an effective and efficient recommender system. Recently, hash-based collaborative filtering (Hash-CF) approaches employ efficient Hamming distance of learned…

Information Retrieval · Computer Science 2022-05-25 Fan Wang , Weiming Liu , Chaochao Chen , Mengying Zhu , Xiaolin Zheng

Predictive coding (PC) offers a local and biologically grounded alternative to backpropagation in the training of artificial neural networks, yet to date, it remains slower, and performance degrades sharply as network depth increases. We…

Machine Learning · Computer Science 2026-05-21 Aleksandrs Baskakovs , Sylvain Estebe , Kenneth Enevoldsen , Kristoffer Nielbo , Chris Mathys , Nicolas Legrand

Embedding-based retrieval aims to learn a shared semantic representation space for both queries and items, enabling efficient and effective item retrieval through approximate nearest neighbor (ANN) algorithms. In current industrial…

Information Retrieval · Computer Science 2025-10-14 Han Zhang , Yunjiang Jiang , Mingming Li , Haowei Yuan , Yiming Qiu , Wen-Yun Yang

Protein sequence generation via stochastic attention produces plausible family members from small alignments without training, but treats all stored sequences equally and cannot direct generation toward a functional subset of interest. We…

Machine Learning · Computer Science 2026-03-23 Jeffrey D. Varner

This paper presents a novel approach to address the challenge of online sequence learning for decision making under uncertainty in non-stationary, partially observable environments. The proposed algorithm, Distributed Hebbian Temporal…

Machine Learning · Computer Science 2025-06-03 Evgenii Dzhivelikian , Petr Kuderov , Aleksandr I. Panov

We introduce a novel Bayesian hybrid matrix factorisation model (HMF) for data integration, based on combining multiple matrix factorisation methods, that can be used for in- and out-of-matrix prediction of missing values. The model is very…

Machine Learning · Statistics 2017-04-18 Thomas Brouwer , Pietro Lió

DNA sequencing, especially of microbial genomes and metagenomes, has been at the core of recent research advances in large-scale comparative genomics. The data deluge has resulted in exponential growth in genomic datasets over the past…