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This work aims to investigate the accuracy of quantitative SPECT imaging of $^{177}$Lu in the presence of $^{90}$Y, which occurs in dual-isotope radiopharmaceutical therapy (RPT) involving both isotopes. We used the GATE Monte Carlo…

Medical Physics · Physics 2023-01-27 Cassandra Miller , Carlos Uribe , Xinchi Hou , Arman Rahmim , Anna Celler

Advances in instrumentation and computation have enabled increasingly sophisticated tomographic reconstruction methods. However, existing evaluation practices -- often based on simple phantoms and global image metrics -- are limited in…

Medical Physics · Physics 2026-04-06 Anna Frixou , Theodoros Leontiou , Efstathios Stiliaris , Costas N. Papanicolas

Photon-counting computed tomography has demonstrated significant advancements in recent years; however, micro photon-counting CT (Micro-PCCT) systems are still limited by pixel-wise detector response nonuniformity, which degrades…

Medical Physics · Physics 2026-03-31 Enze Zhou , Wenjian Li , Wenting Xu , Yuwei Lu , Shangbin Chen , Shaoyang Wang , Gang Zheng , Tianwu Xie , Qian Liu

SPECT (Single-photon Emission Computerized Tomography) and PET (Positron Emission Tomography) are essential medical imaging tools, for which the sampling angle number, scan time should be chosen carefully to compromise between image quality…

Medical Physics · Physics 2015-06-16 Xiaolin Zhou , Minkai Yun , Xuexiang Cao , Shuangquan Liu , Lu Wang , Xianchao Huang , Long Wei

Background: The aim of this study was to assess the robustness of cardiac SPECT radiomics features against changes in imaging settings including acquisition and reconstruction settings. Methods: Four scanners were used to acquire SPECT…

The National Electrical Manufacturers Association's (NEMA) NU 4-2008 standard specifies methodology for evaluating the performance of small-animal PET scanners. The standard's goal is to enable comparison of different PET scanners over a…

Medical Physics · Physics 2020-03-03 Patrick Hallen , David Schug , Volkmar Schulz

Purpose: The main purpose of this study was to assess the reliability of shape and heterogeneity features in both Positron Emission Tomography (PET) and low-dose Computed Tomography (CT) components of PET/CT. A secondary objective was to…

Computer Vision and Pattern Recognition · Computer Science 2016-10-06 Marie-Charlotte Desseroit , Florent Tixier , Wolfgang Weber , Barry A Siegel , Catherine Cheze Le Rest , Dimitris Visvikis , Mathieu Hatt

Purpose: To apply a convolutional neural network (CNN) to develop a system that segments intensity calibration phantom regions in computed tomography (CT) images, and to test the system in a large cohort to evaluate its robustness. Methods:…

Computer Vision and Pattern Recognition · Computer Science 2020-12-22 Keisuke Uemura , Yoshito Otake , Masaki Takao , Mazen Soufi , Akihiro Kawasaki , Nobuhiko Sugano , Yoshinobu Sato

Radio-Stereometric-Analysis and x-ray fluoroscopy are radiological techniques that require dedicated software to process data. The accurate calibration of these software is therefore critical. The aim of this work is to produce a protocol…

Aims. The purpose of this study is to create a multi-stage machine learning model to predict cardiac resynchronization therapy (CRT) response for heart failure (HF) patients. This model exploits uncertainty quantification to recommend…

Purpose: Recent work highlights the breadth of reported spin-lattice relaxation rates ($R_1$) for individual tissues. One potential source of variation is the protocol used to determine $R_1$. The methodological dependence of R1 and…

Medical Physics · Physics 2019-10-01 Christopher Jenkins , Ioannis Papadopoulos , S. M. Shermer

Single Photon Emission Computed Tomography (SPECT) is one of the nuclear medicine imaging modalities used for functional analysis of animal and human organs. Gamma rays emitted from the scanned body are filtered with collimators and…

Image and Video Processing · Electrical Eng. & Systems 2020-12-15 Manu Francis , Muhammed Tarek , Mark Pickering , Murat Tahtali

Purpose: Radiotherapy commonly relies on CT, but there is growing interest in using hybrid PET/MR. Therefore, dedicated hardware setups have been proposed for PET/MR systems which enable imaging in radiotherapy treatment position. These…

Medical Physics · Physics 2024-11-14 R. M. Winter , O. Engelsen , O. J. Bratting , N. Brekke , J. Sæterstøl , O. Sæther , K. R. Redalen

Asteroids (162173) Ryugu and (101955) Bennu observed by Hayabusa2 and OSIRIS-REx share many properties, but spectral observations by the telescopic Optical Navigation Camera (ONC-T) and MapCam detected subtle but significant differences,…

The quality of SPECT Bremsstrahlung images of patients treated with Y-90 is poor, mainly because of scattered radiation and collimator septa penetration. To minimize the latter effect, High Energy (HE) or Medium Energy (ME) collimators can…

We calibrate spectrophotometric optical spectra of 32 stars commonly used as standard stars, referenced to 14 stars already on the HST-based CALSPEC flux system. Observations of CALSPEC and non-CALSPEC stars were obtained with the SuperNova…

Purpose: The expansion of radiopharmaceutical therapy (RPT) development demands scalable preclinical dosimetry methods. While PET and SPECT remain the gold standards, their low throughput and high cost limit large-cohort studies. Cherenkov…

Consumer cameras, particularly onboard smartphones and UAVs, are now commonly used as scientific instruments. However, their data processing pipelines are not optimized for quantitative radiometry and their calibration is more complex than…

Instrumentation and Detectors · Physics 2019-06-25 Olivier Burggraaff , Norbert Schmidt , Jaime Zamorano , Klaas Pauly , Sergio Pascual , Carlos Tapia , Evangelos Spyrakos , Frans Snik

Purpose: The purpose of this work is to develop a new approach for high spatial resolution dosimetry based on Raman micro-spectroscopy scanning of radiochromic film (RCF). We generate dose calibration curves over an extended dose range from…

Medical Physics · Physics 2021-09-15 Connor Mcnairn , Iymad Mansour , Bryan Muir , Rowan M. Thomson , Sangeeta Murugkar

Purpose: To evaluate reliability of upright CT for proton dose calculation and feasibility of a simplified phantom configuration for accelerated routine QA. Methods: A calibration phantom was scanned on an upright CT following consensus…

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