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Living systems operate far from thermodynamic equilibrium. Enzymatic activity can induce broken detailed balance at the molecular scale. This molecular scale breaking of detailed balance is crucial to achieve biological functions such as…

Biological Physics · Physics 2018-05-02 F. Gnesotto , F. Mura , J. Gladrow , C. P. Broedersz

We present a comprehensive study about the relationship between the way Detailed Balance is broken in non-equilibrium systems and the resulting violations of the Fluctuation-Dissipation Theorem. Starting from stochastic dynamics with both…

Statistical Mechanics · Physics 2020-07-16 Sara Dal Cengio , Demian Levis , Ignacio Pagonabarraga

Theoretical and experimental studies have shown that the fluctuations of in vivo systems break the fluctuation-dissipation theorem. One can thus ask what information is contained in the correlation functions of protein concentrations and…

Chemical Physics · Physics 2016-08-24 Hélène Berthoumieux

Active matter systems are driven out of thermal equilibrium by a lack of generalized Stokes-Einstein relation between injection and dissipation of energy at the microscopic scale. We consider such a system of interacting particles,…

Statistical Mechanics · Physics 2016-07-20 Étienne Fodor , Cesare Nardini , Mike E. Cates , Julien Tailleur , Paolo Visco , Frédéric van Wijland

The fluctuation-dissipation (F-D) theorem is a fundamental result for systems near thermodynamic equilibrium, and justifies studies between microscopic and macroscopic properties. It states that the nonequilibrium relaxation dynamics is…

Statistical Mechanics · Physics 2015-03-13 Jianhua Xing

For systems in equilibrium at a temperature $T$, thermal noise and energy damping are related to $T$ through the fluctuation-dissipation theorem (FDT). We study here an extension of the FDT to an out of equilibrium steady state: a…

Statistical Mechanics · Physics 2023-03-23 Alex Fontana , Ludovic Bellon

We propose a model for the dynamics of a probe embedded in a living cell, where both thermal fluctuations and nonequilibrium activity coexist. The model is based on a confining harmonic potential describing the elastic cytoskeletal matrix,…

Biological Physics · Physics 2015-06-18 É. Fodor , M. Guo , N. S. Gov , P. Visco , D. A. Weitz , F. van Wijland

Biological functionality of cellular aggregates is largely influenced by the activity and displacements of individual constituent cells. From a theoretical perspective this activity can be characterized by hydrodynamic transport…

Soft Condensed Matter · Physics 2025-07-31 Subhadip Chakraborti , Vasily Zaburdaev

Living organisms are inherently out-of-equilibrium systems. We employ new developments in stochastic energetics and rely on a minimal microscopic model to predict the amount of mechanical energy dissipated by such dynamics. Our model…

We analyze the validity of the fluctuation-dissipation theorem for slow relaxation systems in the context of mesoscopic nonequilibrium thermodynamics. We demonstrate that the violation arises as a natural consequence of the elimination of…

Statistical Mechanics · Physics 2009-11-07 A. Perez-Madrid , D. Reguera , J. M. Rubi

We probe non-equilibrium properties of an active bacterial bath through measurements of correlations of passive tracer particles and the response function of a driven, optically trapped tracer. These measurements demonstrate violation of…

Soft Condensed Matter · Physics 2009-11-13 D. T. N. Chen , A. W. C. Lau , L. A. Hough , M. F. Islam , M. Goulian , T. C. Lubensky , A. G. Yodh

Kinetic and hydrodynamic theories are widely employed for describing the collective behaviour of active matter systems. At the fluctuating level, these have been obtained from explicit coarse-graining procedures in the limit where each…

Statistical Mechanics · Physics 2022-12-14 Ouassim Feliachi , Marc Besse , Cesare Nardini , Julien Barré

We discuss research done in two important areas of nonequilibrium statistical mechanics: fluctuation dissipation relations and dynamical fluctuations. In equilibrium systems the fluctuation-dissipation theorem gives a simple relation…

Statistical Mechanics · Physics 2010-11-19 Bram Wynants

Active matter systems exhibit rich emergent behavior due to constant injection and dissipation of energy at the level of individual agents. Since these systems are far from equilibrium, their dynamics and energetics cannot be understood…

Soft Condensed Matter · Physics 2020-04-23 Sarah Eldeen , Ryan Muoio , Paris Blaisdell-Pijuan , Ngoc La , Mauricio Gomez , Alex Vidal , Wylie Ahmed

Chemically active systems such as living cells are maintained out of thermal equilibrium due to chemical events which generate heat and lead to active fluctuations. A key question is to understand on which time and length scales active…

Statistical Mechanics · Physics 2023-01-25 Joël Mabillard , Christoph A. Weber , Frank Jülicher

The condition of thermal equilibrium simplifies the theoretical treatment of fluctuations as found in the celebrated Einstein's relation between mobility and diffusivity for Brownian motion. Several recent theories relax the hypothesis of…

Statistical Mechanics · Physics 2014-04-10 Andrea Gnoli , Andrea Puglisi , Alessandro Sarracino , Angelo Vulpiani

Fluctuation theorems are a generalization of thermodynamics on small scales and provide the tools to characterize the fluctuations of thermodynamic quantities in non-equilibrium nanoscale systems. They are particularly important for…

Statistical Mechanics · Physics 2014-04-03 Jan Gieseler , Romain Quidant , Christoph Dellago , Lukas Novotny

Living cells exhibit an important out-of-equilibrium mechanical activity, mainly due to the forces generated by molecular motors. These motor proteins, acting individually or collectively on the cytoskeleton, contribute to the violation of…

Biological Physics · Physics 2009-01-21 Francois Gallet , Delphine Arcizet , Pierre Bohec , Alain Richert

Motivated by the unique physical properties of {\em biological active matter}, e.g., cytoskeletal dynamics in eukaryotic cells, we set up {\em effective} two-dimensional (2d) coarse-grained hydrodynamic equations for the dynamics of thin…

Statistical Mechanics · Physics 2011-06-08 Niladri Sarkar , Abhik Basu

Starting from the kinetic equations for the fluctuations and correlations of a dilute gas of inelastic hard spheres or disks, a Boltzmann-Langevin equation for the one-particle distribution function of the homogeneous cooling state is…

Statistical Mechanics · Physics 2015-05-13 J. Javier Brey , P. Maynar , M. I. Garcia de Soria
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