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We introduce Multi-scale Adaptive Recurrent Biomedical Linear-time Encoder (MARBLE), the first \textit{purely Mamba-based} multi-state multiple instance learning (MIL) framework for whole-slide image (WSI) analysis. MARBLE processes…

Computer Vision and Pattern Recognition · Computer Science 2026-02-04 Jagan Mohan Reddy Dwarampudi , Joshua Wong , Hien Van Nguyen , Tania Banerjee

Image feature matching, a foundational task in computer vision, remains challenging for multimodal image applications, often necessitating intricate training on specific datasets. In this paper, we introduce a Unified Feature Matching…

Computer Vision and Pattern Recognition · Computer Science 2025-03-31 Yide Di , Yun Liao , Hao Zhou , Kaijun Zhu , Qing Duan , Junhui Liu , Mingyu Lu

Current multimodal fusion approaches in computational oncology primarily focus on integrating multi-gigapixel histology whole slide images (WSIs) with genomic or transcriptomic data, demonstrating improved survival prediction. We…

Computer Vision and Pattern Recognition · Computer Science 2025-09-25 Manahil Raza , Ayesha Azam , Talha Qaiser , Nasir Rajpoot

Whole Slide Images (WSIs) exhibit hierarchical structure, where diagnostic information emerges from cellular morphology, regional tissue organization, and global context. Existing Computational Pathology (CPath) Multimodal Large Language…

Computer Vision and Pattern Recognition · Computer Science 2026-03-26 Basit Alawode , Arif Mahmood , Muaz Khalifa Al-Radi , Shahad Albastaki , Asim Khan , Muhammad Bilal , Moshira Ali Abdalla , Mohammed Bennamoun , Sajid Javed

Multimodal change detection (MMCD) identifies changed areas in multimodal remote sensing (RS) data, demonstrating significant application value in land use monitoring, disaster assessment, and urban sustainable development. However,…

Computer Vision and Pattern Recognition · Computer Science 2026-04-08 Xuanguang Liu , Lei Ding , Yujie Li , Chenguang Dai , Zhenchao Zhang , Mengmeng Li , Ziyi Yang , Yifan Sun , Yongqi Sun , Hanyun Wang

In the realm of digital pathology, multi-magnification Multiple Instance Learning (multi-mag MIL) has proven effective in leveraging the hierarchical structure of Whole Slide Images (WSIs) to reduce information loss and redundant data.…

Computer Vision and Pattern Recognition · Computer Science 2024-10-11 Yujian Liu , Ruoxuan Wu , Xinjie Shen , Zihuang Lu , Lingyu Liang , Haiyu Zhou , Shipu Xu , Shaoai Cai , Shidang Xu

Multimodal clinical prediction faces three challenges: multiple foundation models (FMs) with complementary strengths per modality, pervasive missing modalities at training and test time, and sample-specific variation in modality…

Machine Learning · Computer Science 2026-05-19 Seungik Cho , Anqi Li , Wei Qiu

Multimodal pathology-genomic analysis has become increasingly prominent in cancer survival prediction. However, existing studies mainly utilize multi-instance learning to aggregate patch-level features, neglecting the information loss of…

Computer Vision and Pattern Recognition · Computer Science 2025-05-21 Mingcheng Qu , Guang Yang , Donglin Di , Tonghua Su , Yue Gao , Yang Song , Lei Fan

Cancer is a complex disease that provides various types of information depending on the scale of observation. While most tumor diagnostics are performed by observing histopathological slides, radiology images should yield additional…

Image and Video Processing · Electrical Eng. & Systems 2020-10-07 Marvin Lerousseau , Eric Deutsh , Nikos Paragios

Computational pathology (CPath) has significantly advanced the clinical practice of pathology. Despite the progress made, Multiple Instance Learning (MIL), a promising paradigm within CPath, continues to face challenges, particularly…

Computer Vision and Pattern Recognition · Computer Science 2024-08-28 Yuqi Zhang , Xiaoqian Zhang , Jiakai Wang , Yuancheng Yang , Taiying Peng , Chao Tong

Current artificial intelligence models for medical imaging are predominantly single modality and single disease. Attempts to create multimodal and multi-disease models have resulted in inconsistent clinical accuracy. Furthermore, training…

When oncologists estimate cancer patient survival, they rely on multimodal data. Even though some multimodal deep learning methods have been proposed in the literature, the majority rely on having two or more independent networks that share…

Image and Video Processing · Electrical Eng. & Systems 2022-09-13 Numan Saeed , Ikboljon Sobirov , Roba Al Majzoub , Mohammad Yaqub

Effective and efficient task planning is essential for mobile robots, especially in applications like warehouse retrieval and environmental monitoring. These tasks often involve selecting one location from each of several target clusters,…

Artificial Intelligence · Computer Science 2026-03-23 Jiaqi Cheng , Mingfeng Fan , Xuefeng Zhang , Jingsong Liang , Yuhong Cao , Guohua Wu , Guillaume Adrien Sartoretti

Multi-modal fusion approaches aim to integrate information from different data sources. Unlike natural datasets, such as in audio-visual applications, where samples consist of "paired" modalities, data in healthcare is often collected…

Image and Video Processing · Electrical Eng. & Systems 2023-03-03 Nasir Hayat , Krzysztof J. Geras , Farah E. Shamout

Benefiting from the powerful expressive capability of graphs, graph-based approaches have achieved impressive performance in various biomedical applications. Most existing methods tend to define the adjacency matrix among samples manually…

Machine Learning · Computer Science 2021-07-02 Shuai Zheng , Zhenfeng Zhu , Zhizhe Liu , Zhenyu Guo , Yang Liu , Yao Zhao

Real-world problems are often dependent on multiple data modalities, making multimodal fusion essential for leveraging diverse information sources. In high-stakes domains, such as in healthcare, understanding how each modality contributes…

Neural and Evolutionary Computing · Computer Science 2025-05-19 Mafalda Malafaia , Thalea Schlender , Tanja Alderliesten , Peter A. N. Bosman

Recent works on salient object detection have made use of multi-scale features in a way such that high-level features and low-level features can collaborate in locating salient objects. Many of the previous methods have achieved great…

Computer Vision and Pattern Recognition · Computer Science 2022-11-15 Xiaogang Liu Shuang Song

Multimodal machine learning integrating histopathology and molecular data shows promise for cancer prognostication. We systematically reviewed studies combining whole slide images (WSIs) and high-throughput omics to predict overall…

Quantitative Methods · Quantitative Biology 2025-07-30 Charlotte Jennings , Andrew Broad , Lucy Godson , Emily Clarke , David Westhead , Darren Treanor

The early detection and nuanced subtype classification of non-small cell lung cancer (NSCLC), a predominant cause of cancer mortality worldwide, is a critical and complex issue. In this paper, we introduce an innovative integration of…

Image and Video Processing · Electrical Eng. & Systems 2024-10-08 Salma Hassan , Hamad Al Hammadi , Ibrahim Mohammed , Muhammad Haris Khan

Recent advances in artificial intelligence (AI), in particular self-supervised learning of foundation models (FMs), are revolutionizing medical imaging and computational pathology (CPath). A constant challenge in the analysis of digital…

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