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Localization-based imaging has revolutionized fluorescence optical microscopy and has also enabled unprecedented ultrasound images of microvascular structures in deep tissues. Herein, we introduce a new concept of localization optoacoustic…

Optics · Physics 2017-07-10 Xose Luis Dean-Ben , Daniel Razansky

Using spectrally correlated photon pairs instead of classical laser light and coincidence detection instead of light intensity detection, Quantum Optical Coherence Tomography (Q-OCT) outperforms classical OCT in several experimental terms.…

Quantum Physics · Physics 2025-10-06 Sylwia M. Kolenderska , Crislane Vieira de Brito , Piotr Kolenderski

Modern biomedical image analysis using deep learning often encounters the challenge of limited annotated data. To overcome this issue, deep generative models can be employed to synthesize realistic biomedical images. In this regard, we…

Image and Video Processing · Electrical Eng. & Systems 2026-02-23 Yuli Wu , Weidong He , Dennis Eschweiler , Ningxin Dou , Zixin Fan , Shengli Mi , Peter Walter , Johannes Stegmaier

In this paper, we propose a novel retinal layer boundary model for segmentation of optical coherence tomography (OCT) images. The retinal layer boundary model consists of 9 open parametric contours representing the 9 retinal layers in OCT…

Computer Vision and Pattern Recognition · Computer Science 2018-08-10 Jinming Duan , Weicheng Xie , Ryan Wen Liu , Christopher Tench , Irene Gottlob , Frank Proudlock , Li Bai

An orthogonal discrete auditory transform (ODAT) from sound signal to spectrum is constructed by combining the auditory spreading matrix of Schroeder et al and the time one map of a discrete nonlocal Schr\"odinger equation. Thanks to the…

Numerical Analysis · Mathematics 2007-05-23 Jack Xin , Yingyong Qi

Iterative image reconstruction algorithms for optoacoustic tomography (OAT), also known as photoacoustic tomography, have the ability to improve image quality over analytic algorithms due to their ability to incorporate accurate models of…

Analysis of PDEs · Mathematics 2015-06-05 Kun wang , Richard Su , Alexander A. Oraevsky , Mark A. Anastasio

A recent advance in optical coherence tomography (OCT), termed swept-source OCT, is generalized into a new technique, Fourier-domain OCT. It represents a realization of a full-field OCT system in place of the conventional serial image…

Optical projection tomography (OPT) is a powerful tool for biomedical studies. It achieves 3D visualization of mesoscopic biological samples with high spatial resolution using conventional tomographic-reconstruction algorithms. However,…

Computer Vision and Pattern Recognition · Computer Science 2023-10-02 Yan Liu , Jonathan Dong , Thanh-An Pham , Francois Marelli , Michael Unser

We present a computational method for full-range interferometric synthetic aperture microscopy (ISAM) under dispersion encoding. With this, one can effectively double the depth range of optical coherence tomography (OCT), whilst…

Image and Video Processing · Electrical Eng. & Systems 2020-02-03 Jonathan H. Mason , Mike E. Davies , Pierre O. Bagnaninchi

Optical Coherence Tomography Angiography (OCTA) and its derived en-face projections provide high-resolution visualization of the retinal and choroidal vasculature, which is critical for the rapid and accurate diagnosis of retinal diseases.…

Computer Vision and Pattern Recognition · Computer Science 2025-09-10 Pooya Khosravi , Kun Han , Anthony T. Wu , Arghavan Rezvani , Zexin Feng , Xiaohui Xie

Quantum-optical coherence tomography (Q-OCT) provides a dispersion-canceled axial-imaging method, but its practical use is limited by the weakness of the light source and by artifacts in the images. A recent study using chirped-pulse…

Optics · Physics 2016-04-13 Kazuhisa Ogawa , Masao Kitano

Optical coherence tomography (OCT) is a non-invasive volumetric imaging modality with high spatial and temporal resolution. For imaging larger tissue structures, OCT probes need to be moved to scan the respective area. For handheld…

Computer Vision and Pattern Recognition · Computer Science 2026-03-24 Suresh Guttikonda , Maximilian Neidhardt , Vidas Raudonis , Alexander Schlaefer

Optical Doppler Tomography (ODT) is an emerging blood flow analysis technique. A 2D ODT image (B-scan) is generated by sequentially acquiring 1D depth-resolved raw A-scans (A-line) along the lateral axis (B-line), followed by Doppler…

Computer Vision and Pattern Recognition · Computer Science 2026-01-21 Zhenghong Li , Wensheng Cheng , Congwu Du , Yingtian Pan , Zhaozheng Yin , Haibin Ling

In this paper we provide a mathematical model for imaging an anisotropic, orthotropic medium with Polarization-Sensitive Optical Coherence Tomography (PS-OCT). The imaging problem is formulated as an inverse scattering problem in three…

Analysis of PDEs · Mathematics 2018-10-22 Peter Elbau , Leonidas Mindrinos , Otmar Scherzer

We present a general theory of optical coherence tomography (OCT), which synthesizes the fundamental concepts and implementations of OCT under a common 3D k-space framework. At the heart of this analysis is the Fourier diffraction theorem,…

In ultra-high resolution (UHR-) optical coherence tomography (OCT) group velocity dispersion (GVD) must be corrected for in order to approach the theoretical resolution limit. One approach promises not only compensation, but complete…

Multispectral optical imaging is becoming a key tool in the operating room. Recent research has shown that machine learning algorithms can be used to convert pixel-wise reflectance measurements to tissue parameters, such as oxygenation.…

Image and Video Processing · Electrical Eng. & Systems 2019-11-06 Tim J. Adler , Leonardo Ayala , Lynton Ardizzone , Hannes G. Kenngott , Anant Vemuri , Beat P. Müller-Stich , Carsten Rother , Ullrich Köthe , Lena Maier-Hein

Although a lateral-shear interferometer is robust against optical component vibrations, its interferogram provides information about differential wavefronts rather than the wavefronts themselves, resulting in the loss of specific frequency…

Medical imaging is nowadays a pillar in diagnostics and therapeutic follow-up. Current research tries to integrate established - but ionizing - tomographic techniques with technologies offering reduced radiation exposure. Diffuse Optical…

Numerical Analysis · Mathematics 2024-02-15 Alessandro Benfenati , Paola Causin , Martina Quinteri

Optical Coherence Tomography (OCT) is an emerging medical imaging modality for luminal organ diagnosis. The non-constant rotation speed of optical components in the OCT catheter tip causes rotational distortion in OCT volumetric scanning.…