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Instrumental variable (IV) methods are used to estimate causal effects in settings with unobserved confounding, where we cannot directly experiment on the treatment variable. Instruments are variables which only affect the outcome…

Methodology · Statistics 2023-05-26 Elisabeth Ailer , Jason Hartford , Niki Kilbertus

Background: Adaptive interventions provide a guide for using ongoing information about individuals to decide whether and how to modify the type, amount, delivery modality, or timing of treatment, to improve intervention effectiveness while…

Methodology · Statistics 2026-03-12 John J. Dziak , Inbal Nahum-Shani

The predominant method for evaluating the quality of causal models is to measure the graphical accuracy of the learned model structure. We present an alternative method for evaluating causal models that directly measures the accuracy of…

Artificial Intelligence · Computer Science 2016-08-17 Dan Garant , David Jensen

Identifying the underlying reason for a failing dynamic process or otherwise anomalous observation is a fundamental challenge, yet has numerous industrial applications. Identifying the failure-causing sub-system using causal inference, one…

Machine Learning · Computer Science 2024-06-13 Juliane Weilbach , Sebastian Gerwinn , Karim Barsim , Martin Fränzle

There is an increasing interest in estimating heterogeneity in causal effects in randomized and observational studies. However, little research has been conducted to understand heterogeneity in an instrumental variables study. In this work,…

Methodology · Statistics 2021-01-20 Michael Johnson , Jiongyi Cao , Hyunseung Kang

We demonstrate that the algorithmic information content of a system is deeply connected to its potential dynamics, thus affording an avenue for moving systems in the information-theoretic space and controlling them in the phase space. To…

Other Quantitative Biology · Quantitative Biology 2018-04-06 Hector Zenil , Narsis A. Kiani , Francesco Marabita , Yue Deng , Szabolcs Elias , Angelika Schmidt , Gordon Ball , Jesper Tegnér

This paper develops a framework for identification, estimation, and inference on the causal mechanisms driving endogenous social network formation. Identification is challenging because of unobserved confounders and reverse causality;…

Econometrics · Economics 2026-04-21 Maximilian Kasy , Elizabeth Linos , Sanaz Mobasseri

Neural models have demonstrated remarkable performance across diverse ranking tasks. However, the processes and internal mechanisms along which they determine relevance are still largely unknown. Existing approaches for analyzing neural…

Information Retrieval · Computer Science 2025-02-04 Catherine Chen , Jack Merullo , Carsten Eickhoff

When users lack specific knowledge of various system parameters, their uncertainty may lead them to make undesirable deviations in their decision making. To alleviate this, an informed system operator may elect to signal information to…

Computer Science and Game Theory · Computer Science 2023-03-31 Bryce L. Ferguson , Philip N. Brown , Jason R. Marden

Causal Models are increasingly suggested as a means to reason about the behavior of cyber-physical systems in socio-technical contexts. They allow us to analyze courses of events and reason about possible alternatives. Until now, however,…

Artificial Intelligence · Computer Science 2019-11-13 Severin Kacianka , Amjad Ibrahim , Alexander Pretschner , Alexander Trende , Andreas Lüdtke

Identifying causal parameters from observational data is fraught with subtleties due to the issues of selection bias and confounding. In addition, more complex questions of interest, such as effects of treatment on the treated and mediated…

Methodology · Statistics 2015-11-17 Ilya Shpitser , Eric Tchetgen Tchetgen

Latent or continuous chain-of-thought methods replace explicit textual rationales with a number of internal latent steps, but these intermediate computations are difficult to evaluate beyond correlation-based probes. In this paper, we view…

Artificial Intelligence · Computer Science 2026-05-29 Zirui Li , Xuefeng Bai , Kehai Chen , Yizhi Li , Jian Yang , Chenghua Lin , Min Zhang

At the physiological level, aging is neither rigid nor unchangeable. Instead, the molecular and mechanisms driving aging are sufficiently plastic that a variety of diverse interventions--dietary, pharmaceutical, and genetic--have been…

Quantitative Methods · Quantitative Biology 2018-08-28 Nicholas Stroustrup

Sequential experimental design to discover interventions that achieve a desired outcome is a key problem in various domains including science, engineering and public policy. When the space of possible interventions is large, making an…

Machine Learning · Computer Science 2023-08-17 Jiaqi Zhang , Louis Cammarata , Chandler Squires , Themistoklis P. Sapsis , Caroline Uhler

Causal mediation analysis is a powerful tool for disentangling the total effect of a treatment into its direct effect on the outcome and its indirect effect mediated through an intermediate variable. However, in observational studies,…

Econometrics · Economics 2026-04-28 Yuhao Deng , Haoyu Wei , Zhongzhe Ouyang

Causal mediation analysis seeks to determine whether an independent variable affects a response variable directly or whether it does so indirectly, by way of a mediator. The existing statistical tests to determine the existence of an…

Methodology · Statistics 2023-09-28 John Kidd , Dan-Yu Lin

Faced with data-driven policies, individuals will manipulate their features to obtain favorable decisions. While earlier works cast these manipulations as undesirable gaming, recent works have adopted a more nuanced causal framing in which…

Machine Learning · Computer Science 2023-02-22 Tom Yan , Shantanu Gupta , Zachary Lipton

Unlike classical causal inference, which often has an average causal effect of a treatment within a population as a target, in settings such as personalized medicine, the goal is to map a given unit's characteristics to a treatment tailored…

Methodology · Statistics 2017-09-13 Ilya Shpitser , Sourjya Sarkar

Automation and computer intelligence to support complex human decisions becomes essential to manage large and distributed systems in the Cloud and IoT era. Understanding the root cause of an observed symptom in a complex system has been a…

Artificial Intelligence · Computer Science 2017-07-04 Marc Solé , Victor Muntés-Mulero , Annie Ibrahim Rana , Giovani Estrada

Consider a situation with two treatments, the first of which is randomized but the second is not, and the multifactor version of this. Interest is in treatment effects, defined using standard factorial notation. We define estimators for the…