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Sequence alignment data is often ordered by coordinate (id of the reference sequence plus position on the sequence where the fragment was mapped) when stored in BAM files, as this simplifies the extraction of variants between the mapped…

Genomics · Quantitative Biology 2014-06-24 German Tischler , Steven Leonard

Genomic data sets are growing dramatically as the cost of sequencing continues to decline and small sequencing devices become available. Enormous community databases store and share this data with the research community, but some of these…

The ability to scale out training workloads has been one of the key performance enablers of deep learning. The main scaling approach is data-parallel GPU-based training, which has been boosted by hardware and software support for highly…

Distributed, Parallel, and Cluster Computing · Computer Science 2023-01-02 Ilia Markov , Hamidreza Ramezanikebrya , Dan Alistarh

At the core of high throughput DNA sequencing platforms lies a bio-physical surface process that results in a random geometry of clusters of homogenous short DNA fragments typically hundreds of base pairs long - bridge amplification. The…

Genomics · Quantitative Biology 2015-08-13 Eliza O'Reilly , Francois Baccelli , Gustavo de Veciana , Haris Vikalo

DNA sequencing is revolutionising the field of medicine. DNA sequencers, the machines which perform DNA sequencing, have evolved from the size of a fridge to that of a mobile phone over the last two decades. The cost of sequencing a human…

Genomics · Quantitative Biology 2021-01-14 Hasindu Gamaarachchi

Third-generation nanopore sequencers offer a feature called selective sequencing or 'Read Until' that allows genomic reads to be analyzed in real-time and abandoned halfway, if not belonging to a genomic region of 'interest'. This selective…

Hardware Architecture · Computer Science 2022-11-15 Po Jui Shih , Hassaan Saadat , Sri Parameswaran , Hasindu Gamaarachchi

Personalized recommendation systems leverage deep learning models and account for the majority of data center AI cycles. Their performance is dominated by memory-bound sparse embedding operations with unique irregular memory access patterns…

Evolutionary computation has been shown to be a highly effective method for training neural networks, particularly when employed at scale on CPU clusters. Recent work have also showcased their effectiveness on hardware accelerators, such as…

Neural and Evolutionary Computing · Computer Science 2022-04-07 Yujin Tang , Yingtao Tian , David Ha

Gene finding is the task of identifying the locations of coding sequences within the vast amount of genetic code contained in the genome. With an ever increasing quantity of raw genome sequences, gene finding is an important avenue towards…

Genomics · Quantitative Biology 2025-05-07 Frederikke I. Marin , Dennis Pultz , Wouter Boomsma

The search for similar genetic sequences is one of the main bioinformatics tasks. The genetic sequences data banks are growing exponentially and the searching techniques that use linear time are not capable to do the search in the required…

Distributed, Parallel, and Cluster Computing · Computer Science 2015-07-13 Felipe Albrecht

In this paper, a contrastive evaluation of massively parallel implementations of suffix tree and suffix array to accelerate genome sequence matching are proposed based on Intel Core i7 3770K quad-core and NVIDIA GeForce GTX680 GPU. Besides…

Data Structures and Algorithms · Computer Science 2015-05-05 Gang Liao , Qi Sun , Longfei Ma , Sha Ding , Wen Xie

In the last decade a number of algorithms and associated software have been developed to align next generation sequencing (NGS) reads with relevant reference genomes. The accuracy of these programs may vary significantly, especially when…

The advent of high-throughput sequencing technologies has revolutionized genome analysis by enabling the rapid and cost-effective sequencing of large genomes. Despite these advancements, the increasing complexity and volume of genomic data…

Genomics · Quantitative Biology 2025-03-06 Can Firtina

Reducing the cost of sequencing genomes provided by next-generation sequencing technologies has greatly increased the number of genomic projects. As a result, there is a growing need for better assembly and assembly validation methods. One…

Genomics · Quantitative Biology 2022-10-17 Przemysław Stawczyk , Robert Nowak

Accurate identification of haplotypes in sequenced human genomes can provide invaluable information about population demography and fine-scale correlations along the genome, thus empowering both population genomic and medical association…

Genomics · Quantitative Biology 2012-11-12 Fouad Zakharia , Carlos Bustamante

This paper focuses on pattern matching in the DNA sequence. It was inspired by a previously reported method that proposes encoding both pattern and sequence using prime numbers. Although fast, the method is limited to rather small pattern…

Computer Vision and Pattern Recognition · Computer Science 2016-11-21 Janja Paliska Soldo , Ana Sovic Krzic , and Damir Sersic

Transformers are central to advances in artificial intelligence (AI), excelling in fields ranging from computer vision to natural language processing. Despite their success, their large parameter count and computational demands challenge…

Hardware Architecture · Computer Science 2025-03-10 Qunyou Liu , Marina Zapater , David Atienza

Background: Identifying all possible mapping locations of next-generation sequencing (NGS) reads is highly essential in several applications such as prediction of genomic variants or protein binding motifs located in repeat regions, isoform…

Genomics · Quantitative Biology 2020-03-25 Ngoc Hieu Tran , Xin Chen

GitHub Copilot, an extension for the Visual Studio Code development environment powered by the large-scale language model Codex, makes automatic program synthesis available for software developers. This model has been extensively studied in…

Software Engineering · Computer Science 2021-11-16 Dominik Sobania , Martin Briesch , Franz Rothlauf

We present EvoSort, a general-purpose adaptive parallel parallel sorting framework accessible at the Python level. EvoSort employs a Genetic Algorithm (GA) to automatically discover and refine critical parameters, including insertion sort…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-01-05 Shashank Raj , Kalyanmoy Deb
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