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Traumatic axonal injury occurs when loads experienced on the tissue-scale are transferred to the individual axons. Mechanical characterization of axon deformation especially under dynamic loads however is extremely difficult owing to their…

Applied Physics · Physics 2023-04-14 Parameshwaran Pasupathy , John G Georgiadis , Assimina A Pelegri

A novel 3D micromechanical Finite Element Model (FEM) has been developed to depict the Poynting effect in bi-phasic Representative volume element (RVE) with axons embedded in surrounding extra-cellular matrix (ECM) for simulating the brain…

Medical Physics · Physics 2023-05-03 Mohit Agarwal , Assimina A. Pelegri

A novel finite element method (FEM) is developed to study mechanical response of axons embedded in extra cellular matrix (ECM) when subjected to harmonic uniaxial stretch under purely non-affine kinematic boundary conditions. The proposed…

Biological Physics · Physics 2022-05-06 Mohit Agarwal , Assimina A. Pelegri

Brain mechanics is a topic of deep interest because of the significant role of mechanical cues in both brain function and form. Specifically, capturing the heterogeneous and anisotropic behaviour of cerebral white matter (WM) is extremely…

Soft Condensed Matter · Physics 2021-10-20 Asad Jamal , Andrea Bernardini , Daniele Dini

Source localization based on electroencephalography (EEG) has become a widely used neuroimagining technique. However its precision has been shown to be very dependent on how accurately the brain, head and scalp can be electrically modeled…

Medical Physics · Physics 2020-04-22 Lyes Rahmouni , Adrien Merlini , Axelle Pillain , Francesco P. Andriulli

Soft materials often exhibit a distinctive power-law viscoelastic response arising from broad distribution of time-scales present in their complex internal structure. A promising tool to accurately describe the rheological behaviour of soft…

Soft Condensed Matter · Physics 2020-07-17 Alessandra Bonfanti , Jonathan Louis Kaplan , Guillaume Charras , Alexandre J Kabla

The simulation of a short fibre reinforced structure by means of the FEM requires the knowledge of the material behaviour at every Gauss point. In order to obtain such information, a representative volume element (RVE) containing…

Materials Science · Physics 2014-08-21 N. Goldberg , H. Donner , J. Ihlemann

The surface Boundary Element Method (BEM) is one of the most commonly employed formulations to solve the forward problem in electroencephalography, but the applicability of its classical incarnations is lamentably limited to piece-wise…

Image and Video Processing · Electrical Eng. & Systems 2020-04-27 Maxime Y. Monin , Lyes Rahmouni , Francesco P. Andriulli

A precise domain triangulation is recognized as indispensable for the accurate numerical approximation of differential operators within collocation methods, leading to a substantial reduction in discretization errors. An efficient finite…

Numerical Analysis · Mathematics 2025-07-15 G. Shylaja , V. Kesavulu Naidu , B. Venkatesh , S. M. Mallikarjunaiah

We develop a thermodynamically consistent, fractional visco-elasto-plastic model coupled with damage for anomalous materials. The model utilizes Scott-Blair rheological elements for both visco-elastic/plastic parts. The constitutive…

Numerical Analysis · Mathematics 2019-11-19 Jorge L. Suzuki , Yongtao Zhou , Marta D'Elia , Mohsen Zayernouri

Mechanical models of brain tissue are a beneficial tool to simulate neurosurgical interventions, disease progression, or brain development. However, the accuracy and predictive capacity of such a model relies on a precise experimental…

Medical Physics · Physics 2026-05-29 Laura Ruhland , Nina Reiter , Silvia Budday , Kai Willner

Computational biomechanics plays an important role in biomedical engineering: using modeling to understand pathophysiology, treatment and device design. While experimental evidence indicates that the mechanical response of most tissues is…

Numerical Analysis · Mathematics 2020-02-19 Will Zhang , Adela Capilnasiu , Gerhard Sommer

Constitutive models that describe the mechanical behavior of soft tissues have advanced greatly over the past few decades. These expert models are generalizable and require the calibration of a number of parameters to fit experimental data.…

Quantitative Methods · Quantitative Biology 2021-07-13 Vahidullah Tac , Vivek D. Sree , Manuel K. Rausch , Adrian B. Tepole

We introduce a data-driven fractional modeling framework aimed at complex materials, and particularly bio-tissues. From multi-step relaxation experiments of distinct anatomical locations of porcine urinary bladder, we identify an anomalous…

Numerical Analysis · Mathematics 2021-10-04 Jorge L. Suzuki , Tyler G. Tuttle , Sara Roccabianca , Mohsen Zayernouri

We develop a fractional return-mapping framework for power-law visco-elasto-plasticity. In our approach, the fractional viscoelasticity is accounted through canonical combinations of Scott-Blair elements to construct a series of well-known…

Numerical Analysis · Mathematics 2022-10-05 Jorge L. Suzuki , Maryam Naghibolhosseini , Mohsen Zayernouri

Fractional models and their parameters are sensitive to changes in the intrinsic micro-structures of anomalous materials. We investigate how such physics-informed models propagate the evolving anomalous rheology to the nonlinear dynamics of…

Numerical Analysis · Mathematics 2020-09-28 Jorge L. Suzuki , Pegah Varghaei , Ehsan Kharazmi , Mohsen Zayernouri

The present paper is the second part of a twofold work, whose first part is reported in [3], concerning a newly developed Virtual Element Method (VEM) for 2D continuum problems. The first part of the work proposed a study for linear elastic…

Numerical Analysis · Mathematics 2018-10-24 Edoardo Artioli , Lourenco Beirão da Veiga , Carlo Lovadina , Elio Sacco

In this work, possibility of simulating biological organs in realtime using the Boundary Element Method (BEM) is investigated. Biological organs are assumed to follow linear elastostatic material behavior, and constant boundary element is…

Computational Engineering, Finance, and Science · Computer Science 2014-02-11 Kirana Kumara P

The constitutive behavior of polymeric materials is often modeled by finite linear viscoelastic (FLV) or quasi-linear viscoelastic (QLV) models. These popular models are simplifications that typically cannot accurately capture the nonlinear…

Materials Science · Physics 2023-03-23 Kian P. Abdolazizi , Kevin Linka , Christian J. Cyron

We demonstrate that the method of characterizing viscoelastic materials with Atomic Force Microscopy (AFM) by fitting analytical models to force-distance (FD) curves often yields conflicting and physically unrealistic results. Because this…

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