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Standard approaches to analysing data in genome-wide association studies (GWAS) ignore any potential functional relationships between genetic markers. In contrast gene pathways analysis uses prior information on functional structure within…

Methodology · Statistics 2013-02-26 M. Silver , P. Chen , L. Ruoying , C. Y. Cheng , T. Y. Wong , E. Tai , Y. Y. Teo , G. Montana

Unsupervised learning aims at the discovery of hidden structure that drives the observations in the real world. It is essential for success in modern machine learning. Latent variable models are versatile in unsupervised learning and have…

Machine Learning · Computer Science 2016-06-13 Furong Huang

Deep autoencoders are often extended with a supervised or adversarial loss to learn latent representations with desirable properties, such as greater predictivity of labels and outcomes or fairness with respects to a sensitive variable.…

Machine Learning · Statistics 2022-01-10 William E. Carson , Austin Talbot , David Carlson

Graph neural networks have been used for a variety of learning tasks, such as link prediction, node classification, and node clustering. Among them, link prediction is a relatively under-studied graph learning task, with current…

Machine Learning · Computer Science 2022-08-29 Xinxing Wu , Qiang Cheng

Bias in AI systems, especially those relying on natural language data, raises ethical and practical concerns. Underrepresentation of certain groups often leads to uneven performance across demographics. Traditional fairness methods, such as…

Computation and Language · Computer Science 2025-10-16 Sai Suhruth Reddy Karri , Yashwanth Sai Nallapuneni , Laxmi Narasimha Reddy Mallireddy , Gopichand G

Variational autoencoders (VAEs) are widely used deep generative models capable of learning unsupervised latent representations of data. Such representations are often difficult to interpret or control. We consider the problem of…

Machine Learning · Computer Science 2018-12-18 Jack Klys , Jake Snell , Richard Zemel

The massive growth of network traffic data leads to a large volume of datasets. Labeling these datasets for identifying intrusion attacks is very laborious and error-prone. Furthermore, network traffic data have complex time-varying…

Cryptography and Security · Computer Science 2022-04-11 Amardeep Singh , Julian Jang-Jaccard

We introduce a novel masked graph autoencoder (MGAE) framework to perform effective learning on graph structure data. Taking insights from self-supervised learning, we randomly mask a large proportion of edges and try to reconstruct these…

Machine Learning · Computer Science 2022-01-10 Qiaoyu Tan , Ninghao Liu , Xiao Huang , Rui Chen , Soo-Hyun Choi , Xia Hu

Counterfactual explanations (CEs) provide recourse recommendations for individuals affected by algorithmic decisions. A key challenge is generating CEs that are robust against various perturbation types (e.g. input and model perturbations)…

Machine Learning · Computer Science 2026-03-02 Junqi Jiang , Francesco Leofante , Antonio Rago , Francesca Toni

Unsupervised representation learning holds the promise of exploiting large amounts of unlabeled data to learn general representations. A promising technique for unsupervised learning is the framework of Variational Auto-encoders (VAEs).…

Computer Vision and Pattern Recognition · Computer Science 2020-04-09 Kamal Gupta , Saurabh Singh , Abhinav Shrivastava

Gene expression is a readily-observed quantification of transcriptional activity and cellular state that enables the recovery of the relationships between regulators and their target genes. Reconstructing transcriptional regulatory networks…

Molecular Networks · Quantitative Biology 2016-09-22 Anthony Gitter , Furong Huang , Ragupathyraj Valluvan , Ernest Fraenkel , Animashree Anandkumar

Variable selection is crucial in high-dimensional omics-based analyses, since it is biologically reasonable to assume only a subset of non-noisy features contributes to the data structures. However, the task is particularly hard in an…

Methodology · Statistics 2022-03-22 Emilie Eliseussen , Thomas Fleischer , Valeria Vitelli

Heterogeneity is a fundamental characteristic of cancer. To accommodate heterogeneity, subgroup identification has been extensively studied and broadly categorized into unsupervised and supervised analysis. Compared to unsupervised…

Methodology · Statistics 2026-02-25 Xing Qin , Xu Liu , Shuangge Ma , Mengyun Wu

Unsupervised anomaly detection aims to identify anomalous samples from highly complex and unstructured data, which is pervasive in both fundamental research and industrial applications. However, most existing methods neglect the complex…

Machine Learning · Computer Science 2020-10-20 Haoyi Fan , Fengbin Zhang , Ruidong Wang , Liang Xi , Zuoyong Li

Recently, using large language models (LLMs) for data augmentation has led to considerable improvements in unsupervised sentence embedding models. However, existing methods encounter two primary challenges: limited data diversity and high…

Computation and Language · Computer Science 2025-10-07 Peichao Lai , Zhengfeng Zhang , Wentao Zhang , Fangcheng Fu , Bin Cui

Graph Convolutional Networks (GCNs) achieve great success in non-Euclidean structure data processing recently. In existing studies, deeper layers are used in CCNs to extract deeper features of Euclidean structure data. However, for…

Machine Learning · Computer Science 2022-03-14 Junhua Ma , Jiajun Li , Xueming Li , Xu Li

We introduce the variational graph auto-encoder (VGAE), a framework for unsupervised learning on graph-structured data based on the variational auto-encoder (VAE). This model makes use of latent variables and is capable of learning…

Machine Learning · Statistics 2016-11-23 Thomas N. Kipf , Max Welling

Extracting meaningful information from high-dimensional data poses a formidable modeling challenge, particularly when the data is obscured by noise or represented through different modalities. This research proposes a novel non-parametric…

Machine Learning · Computer Science 2024-08-27 Navid Ziaei , Behzad Nazari , Uri T. Eden , Alik Widge , Ali Yousefi

Generative graph self-supervised learning (SSL) aims to learn node representations by reconstructing the input graph data. However, most existing methods focus on unsupervised learning tasks only and very few work has shown its superiority…

Machine Learning · Computer Science 2023-02-08 Xiang Li , Tiandi Ye , Caihua Shan , Dongsheng Li , Ming Gao

Recent methods for self-supervised learning can be grouped into two paradigms: contrastive and non-contrastive approaches. Their success can largely be attributed to data augmentation pipelines which generate multiple views of a single…

Machine Learning · Computer Science 2022-02-08 William Falcon , Ananya Harsh Jha , Teddy Koker , Kyunghyun Cho