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We present a reconstruction method involving maximum-likelihood expectation maximization (MLEM) to model Poisson noise as applied to fluorescence molecular tomography (FMT). MLEM is initialized with the output from a sparse…

Medical Physics · Physics 2018-04-03 Yansong Zhu , Abhinav K. Jha , Dean F. Wong , Arman Rahmim

The National Electrical Manufacturers Association's (NEMA) NU 4-2008 standard specifies methodology for evaluating the performance of small-animal PET scanners. The standard's goal is to enable comparison of different PET scanners over a…

Medical Physics · Physics 2020-03-03 Patrick Hallen , David Schug , Volkmar Schulz

Tumor segmentation in PET-CT images is challenging due to the dual nature of the acquired information: low metabolic information in CT and low spatial resolution in PET. U-Net architecture is the most common and widely recognized approach…

Image and Video Processing · Electrical Eng. & Systems 2022-10-06 Simone Bendazzoli , Mehdi Astaraki

Low-count positron emission tomography (LCPET) imaging can reduce patients' exposure to radiation but often suffers from increased image noise and reduced lesion detectability, necessitating effective denoising techniques. Diffusion models…

Image and Video Processing · Electrical Eng. & Systems 2025-03-24 Yinchi Zhou , Huidong Xie , Menghua Xia , Qiong Liu , Bo Zhou , Tianqi Chen , Jun Hou , Liang Guo , Xinyuan Zheng , Hanzhong Wang , Biao Li , Axel Rominger , Kuangyu Shi , Nicha C. Dvorneka , Chi Liu

PET suffers from a low signal-to-noise ratio. Meanwhile, the k-space data acquisition process in MRI is time-consuming by PET-MRI systems. We aim to accelerate MRI and improve PET image quality. This paper proposed a novel joint…

Computer Vision and Pattern Recognition · Computer Science 2024-08-23 Taofeng Xie , Zhuoxu Cui , Congcong Liu , Chen Luo , Huayu Wang , Yuanzhi Zhang , Xuemei Wang , Yihang Zhou , Qiyu Jin , Guoqing Chen , Dong Liang , Haifeng Wang

Synthesizing amyloid PET scans from the more widely available and accessible structural MRI modality offers a promising, cost-effective approach for large-scale Alzheimer's Disease (AD) screening. This is motivated by evidence that, while…

Image and Video Processing · Electrical Eng. & Systems 2025-11-12 Alec Sargood , Lemuel Puglisi , James H. Cole , Neil P. Oxtoby , Daniele Ravì , Daniel C. Alexander

Deep image prior (DIP) has been successfully applied to positron emission tomography (PET) image restoration, enabling represent implicit prior using only convolutional neural network architecture without training dataset, whereas the…

Medical Physics · Physics 2024-04-23 Yuya Onishi , Fumio Hashimoto , Kibo Ote , Keisuke Matsubara , Masanobu Ibaraki

The ability to synthesise Computed Tomography images - commonly known as pseudo CT, or pCT - from MRI input data is commonly assessed using an intensity-wise similarity, such as an L2-norm between the ground truth CT and the pCT. However,…

Image and Video Processing · Electrical Eng. & Systems 2020-04-15 Kerstin Kläser , Thomas Varsavsky , Pawel Markiewicz , Tom Vercauteren , David Atkinson , Kris Thielemans , Brian Hutton , M Jorge Cardoso , Sebastien Ourselin

Although supervised convolutional neural networks (CNNs) often outperform conventional alternatives for denoising positron emission tomography (PET) images, they require many low- and high-quality reference PET image pairs. Herein, we…

Medical Physics · Physics 2021-09-29 Yuya Onishi , Fumio Hashimoto , Kibo Ote , Hiroyuki Ohba , Ryosuke Ota , Etsuji Yoshikawa , Yasuomi Ouchi

In this paper, we provide a novel method for the estimation of unknown parameters of the Gaussian Mixture Model (GMM) in Positron Emission Tomography (PET). A vast majority of PET imaging methods are based on reconstruction model that is…

Signal Processing · Electrical Eng. & Systems 2023-06-30 Tomislav Matulić , Damir Seršić

Parameter-efficient transfer learning (PETL) is proposed as a cost-effective way to transfer pre-trained models to downstream tasks, avoiding the high cost of updating entire large-scale pre-trained models (LPMs). In this work, we present…

Computer Vision and Pattern Recognition · Computer Science 2024-07-03 Yijin Huang , Pujin Cheng , Roger Tam , Xiaoying Tang

High noise and low spatial resolution are two key confounding factors that limit the qualitative and quantitative accuracy of PET images. AI models for image denoising and deblurring are becoming increasingly popular for post-reconstruction…

Image and Video Processing · Electrical Eng. & Systems 2022-07-19 Juan Liu , Masoud Malekzadeh , Niloufar Mirian , Tzu-An Song , Chi Liu , Joyita Dutta

Direct reconstruction methods have been developed to estimate parametric images directly from the measured PET sinograms by combining the PET imaging model and tracer kinetics in an integrated framework. Due to limited counts received,…

Image and Video Processing · Electrical Eng. & Systems 2021-06-22 Kuang Gong , Ciprian Catana , Jinyi Qi , Quanzheng Li

PET is affected by statistical noise due to constraints on tracer dose and scan duration, impacting both diagnostic performance and quantitative accuracy. While deep learning (DL)-based PET denoising methods have been used to improve image…

Accelerated MRI reconstruction involves solving an ill-posed inverse problem where noise in acquired data propagates to the reconstructed images. Noise analyses are central to MRI reconstruction for providing an explicit measure of solution…

Computer Vision and Pattern Recognition · Computer Science 2025-05-06 Onat Dalmaz , Arjun D. Desai , Reinhard Heckel , Tolga Çukur , Akshay S. Chaudhari , Brian A. Hargreaves

Positron Emission Tomography (PET) is a vital imaging modality widely used in clinical diagnosis and preclinical research but faces limitations in image resolution and signal-to-noise ratio due to inherent physical degradation factors.…

Image and Video Processing · Electrical Eng. & Systems 2024-11-11 Boxiao Yu , Kuang Gong

The recently proposed sparsifying transform models incur low computational cost and have been applied to medical imaging. Meanwhile, deep models with nested network structure reveal great potential for learning features in different layers.…

Image and Video Processing · Electrical Eng. & Systems 2022-03-23 Xikai Yang , Zhishen Huang , Yong Long , Saiprasad Ravishankar

Recent medical imaging studies have given rise to distinct but inter-related datasets corresponding to multiple experimental tasks or longitudinal visits. Standard scalar-on-image regression models that fit each dataset separately are not…

Methodology · Statistics 2022-01-21 Xin Ma , Suprateek Kundu

Current state-of-the-art medical image segmentation methods prioritize accuracy but often at the expense of increased computational demands and larger model sizes. Applying these large-scale models to the relatively limited scale of medical…

Computer Vision and Pattern Recognition · Computer Science 2024-01-17 Jiahui Zhong , Wenhong Tian , Yuanlun Xie , Zhijia Liu , Jie Ou , Taoran Tian , Lei Zhang

In this paper, we explore a novel method for tomographic image reconstruction in the field of SPECT imaging. Deep Learning methodologies and more specifically deep convolutional neural networks (CNN) are employed in the new reconstruction…

Machine Learning · Computer Science 2020-10-20 Charalambos Chrysostomou , Loizos Koutsantonis , Christos Lemesios , Costas N. Papanicolas
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