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Intelligent medical image analysis is essential for clinical decision support but is often limited by scarce annotations, constrained computational resources, and suboptimal model generalization. To address these challenges, we propose a…

Computer Vision and Pattern Recognition · Computer Science 2026-01-26 Jingsong Xia , Siqi Wang

Traditional domain generalization methods often rely on domain alignment to reduce inter-domain distribution differences and learn domain-invariant representations. However, domain shifts are inherently difficult to eliminate, which limits…

Computer Vision and Pattern Recognition · Computer Science 2024-12-10 Yuheng Xu , Taiping Zhang

Generalising deep models to new data from new centres (termed here domains) remains a challenge. This is largely attributed to shifts in data statistics (domain shifts) between source and unseen domains. Recently, gradient-based…

Computer Vision and Pattern Recognition · Computer Science 2021-10-05 Xiao Liu , Spyridon Thermos , Alison O'Neil , Sotirios A. Tsaftaris

Clinical machine learning models experience significantly degraded performance in datasets not seen during training, e.g., new hospitals or populations. Recent developments in domain generalization offer a promising solution to this problem…

Machine Learning · Computer Science 2021-04-16 Haoran Zhang , Natalie Dullerud , Laleh Seyyed-Kalantari , Quaid Morris , Shalmali Joshi , Marzyeh Ghassemi

Recently, we have witnessed great progress in the field of medical imaging classification by adopting deep neural networks. However, the recent advanced models still require accessing sufficiently large and representative datasets for…

Computer Vision and Pattern Recognition · Computer Science 2020-10-30 Haoliang Li , YuFei Wang , Renjie Wan , Shiqi Wang , Tie-Qiang Li , Alex C. Kot

Medical image segmentation plays a crucial role in clinical workflows, but domain shift often leads to performance degradation when models are applied to unseen clinical domains. This challenge arises due to variations in imaging…

Computer Vision and Pattern Recognition · Computer Science 2025-08-01 Yingkai Wang , Yaoyao Zhu , Xiuding Cai , Yuhao Xiao , Haotian Wu , Yu Yao

In medical imaging, the heterogeneity of multi-centre data impedes the applicability of deep learning-based methods and results in significant performance degradation when applying models in an unseen data domain, e.g. a new centreor a new…

Computer Vision and Pattern Recognition · Computer Science 2020-08-12 Hongwei Li , Timo Loehr , Anjany Sekuboyina , Jianguo Zhang , Benedikt Wiestler , Bjoern Menze

Deep learning models usually suffer from domain shift issues, where models trained on one source domain do not generalize well to other unseen domains. In this work, we investigate the single-source domain generalization problem: training a…

Computer Vision and Pattern Recognition · Computer Science 2023-04-24 Cheng Ouyang , Chen Chen , Surui Li , Zeju Li , Chen Qin , Wenjia Bai , Daniel Rueckert

The success of deep learning has set new benchmarks for many medical image analysis tasks. However, deep models often fail to generalize in the presence of distribution shifts between training (source) data and test (target) data. One…

Image and Video Processing · Electrical Eng. & Systems 2022-06-28 Dwarikanath Mahapatra

Emerging diseases present challenges in symptom recognition and timely clinical intervention due to limited available information. An effective prognostic model could assist physicians in making accurate diagnoses and designing personalized…

Machine Learning · Computer Science 2025-02-12 Zhongji Zhang , Yuhang Wang , Yinghao Zhu , Xinyu Ma , Yasha Wang , Junyi Gao , Liantao Ma , Wen Tang , Xiaoyun Zhang , Ling Wang

Deep learning models perform best when tested on target (test) data domains whose distribution is similar to the set of source (train) domains. However, model generalization can be hindered when there is significant difference in the…

Computer Vision and Pattern Recognition · Computer Science 2020-08-19 Pulkit Khandelwal , Paul Yushkevich

Domain generalization is a technique aimed at enabling models to maintain high accuracy when applied to new environments or datasets (unseen domains) that differ from the datasets used in training. Generally, the accuracy of models trained…

Computer Vision and Pattern Recognition · Computer Science 2026-04-09 Reiji Saito , Kazuhiro Hotta

Computer-aided detection systems based on deep learning have shown great potential in breast cancer detection. However, the lack of domain generalization of artificial neural networks is an important obstacle to their deployment in changing…

Image and Video Processing · Electrical Eng. & Systems 2023-01-25 Lidia Garrucho , Kaisar Kushibar , Socayna Jouide , Oliver Diaz , Laura Igual , Karim Lekadir

Generalization capability to unseen domains is crucial for machine learning models when deploying to real-world conditions. We investigate the challenging problem of domain generalization, i.e., training a model on multi-domain source data…

Computer Vision and Pattern Recognition · Computer Science 2019-10-31 Qi Dou , Daniel C. Castro , Konstantinos Kamnitsas , Ben Glocker

Labeling medical images is a major bottleneck in the field of medical imaging, as it requires domain-specific expertise, and it gets further complicated due to variability across different medical centers and different imaging devices. Such…

Computer Vision and Pattern Recognition · Computer Science 2026-05-06 Sapna Sachan , Rakesh Kumar Sanodiya , Amulya Kumar Mahto

The domain generalization problem has been widely investigated in deep learning for non-contrast imaging over the last years, but it received limited attention for contrast-enhanced imaging. However, there are marked differences in contrast…

Domain-invariant representation learning is a powerful method for domain generalization. Previous approaches face challenges such as high computational demands, training instability, and limited effectiveness with high-dimensional data,…

Computer Vision and Pattern Recognition · Computer Science 2024-11-25 Yuheng Xu , Taiping Zhang

Deep learning-based models in medical imaging often struggle to generalize effectively to new scans due to data heterogeneity arising from differences in hardware, acquisition parameters, population, and artifacts. This limitation presents…

Image and Video Processing · Electrical Eng. & Systems 2023-08-09 Sebastian Nørgaard Llambias , Mads Nielsen , Mostafa Mehdipour Ghazi

Convolutional neural network (CNN), in particular the Unet, is a powerful method for medical image segmentation. To date Unet has demonstrated state-of-art performance in many complex medical image segmentation tasks, especially under the…

Image and Video Processing · Electrical Eng. & Systems 2019-10-31 Wenjun Yan , Yuanyuan Wang , Shengjia Gu , Lu Huang , Fuhua Yan , Liming Xia , Qian Tao

Domain shift refers to the well known problem that a model trained in one source domain performs poorly when applied to a target domain with different statistics. {Domain Generalization} (DG) techniques attempt to alleviate this issue by…

Machine Learning · Computer Science 2017-10-11 Da Li , Yongxin Yang , Yi-Zhe Song , Timothy M. Hospedales
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