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In many contemporary applications such as healthcare, finance, robotics, and recommendation systems, continuous deployment of new policies for data collection and online learning is either cost ineffective or impractical. We consider a…

Machine Learning · Computer Science 2021-06-07 DiJia Su , Jason D. Lee , John M. Mulvey , H. Vincent Poor

Optimizing objective functions stands to benefit significantly from leveraging quantum computers, promising enhanced solution quality across various application domains in the future. However, harnessing the potential of quantum solvers…

Quantum Physics · Physics 2025-10-15 Deborah Volpe , Nils Quetschlich , Mariagrazia Graziano , Giovanna Turvani , Robert Wille

The quantum approximate optimization algorithm (QAOA) is designed to determine optimum and near optimum solutions of quadratic (and higher order) unconstrained binary optimization (QUBO or HUBO) problems, which in turn accurately model…

Quantum Physics · Physics 2025-03-18 Prashanti Priya Angara , Danylo Lykov , Ulrike Stege , Yuri Alexeev , Hausi Müller

Here, we present two complementary approaches that advance quadratic unconstrained binary optimization (QUBO) toward practical use in data-driven materials design and other real-valued black-box optimization tasks. First, we introduce a…

Materials Science · Physics 2025-12-15 Thomas Plehn , Daniel Barragan-Yani , Eric Breitbarth , Guillermo Requena , David Melching

For various optimization problems, the classical time to solution is super-polynomial and intractable to solve with classical bit-based computing hardware to date. Digital and quantum annealers have the potential to identify near-optimal…

Quantum Physics · Physics 2025-11-05 Milind Upadhyay , Mark Nicholas Jones

Heterogeneous HPC workflow scheduling under multiple hard constraints poses a challenging combinatorial optimization problem. Classical exact solvers guarantee optimality but face scalability limits, motivating interest in quantum-inspired…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-05-26 Aasish Kumar Sharma , Christian Boehme , Julian Kunkel

Quantum computing and quantum Monte Carlo (QMC) are respectively the state-of-the-art quantum and classical computing methods for understanding many-body quantum systems. Here, we propose a hybrid quantum-classical algorithm that integrates…

Quantum Physics · Physics 2025-11-17 Yukun Zhang , Yifei Huang , Jinzhao Sun , Dingshun Lv , Xiao Yuan

We present a hybrid classical-quantum framework based on the Frank-Wolfe algorithm, Q-FW, for solving quadratic, linearly-constrained, binary optimization problems on quantum annealers (QA). The computational premise of quantum computers…

Computer Vision and Pattern Recognition · Computer Science 2022-03-25 Alp Yurtsever , Tolga Birdal , Vladislav Golyanik

The Cable Routing Optimization Problem (CROP) is a Multi-Commodity Flow Problem (MCFP) central to industrial layouts and smart manufacturing. Historically, quantum optimization has modeled MCFPs as Quadratic Unconstrained Binary…

Quantum Approximate Optimization Algorithm (QAOA) and Quantum Annealing are prominent approaches for solving combinatorial optimization problems, such as those formulated as Quadratic Unconstrained Binary Optimization (QUBO). These…

Monte Carlo Exploring Starts (MCES), which aims to learn the optimal policy using only sample returns, is a simple and natural algorithm in reinforcement learning which has been shown to converge under various conditions. However, the…

Machine Learning · Computer Science 2024-10-07 Suei-Wen Chen , Keith Ross , Pierre Youssef

In this paper, we present an online reinforcement learning algorithm, called Renewal Monte Carlo (RMC), for infinite horizon Markov decision processes with a designated start state. RMC is a Monte Carlo algorithm and retains the advantages…

Machine Learning · Computer Science 2018-04-05 Jayakumar Subramanian , Aditya Mahajan

Reinforcement learning studies how an agent should interact with an environment to maximize its cumulative reward. A standard way to study this question abstractly is to ask how many samples an agent needs from the environment to learn an…

Quantum Physics · Physics 2021-12-21 Daochen Wang , Aarthi Sundaram , Robin Kothari , Ashish Kapoor , Martin Roetteler

In recent years, there has been significant research interest in solving Quadratic Unconstrained Binary Optimisation (QUBO) problems. Physics-inspired optimisation algorithms have been proposed for deriving optimal or sub-optimal solutions…

Artificial Intelligence · Computer Science 2023-09-12 Mayowa Ayodele , Richard Allmendinger , Manuel López-Ibáñez , Matthieu Parizy

Renewable energy optimisation poses computationally-intensive challenges. Yet, often the continuous nature of the decision space precludes the use of many emerging, non-von-Neumann computing platforms such as quantum annealing, which are…

Quantum Physics · Physics 2022-04-05 Mansour T. A. Sharabiani , Vibe B. Jakobsen , Martin Jeppesen , Alireza S. Mahani

Several combinatorial optimization problems can be solved with NISQ devices once that a corresponding quadratic unconstrained binary optimization (QUBO) form is derived. The aim of this work is to drastically reduce the variables needed for…

Quantum Physics · Physics 2026-02-25 Dario De Santis , Salvatore Tirone , Stefano Marmi , Vittorio Giovannetti

Classical reinforcement learning (RL) aims to optimize the expected cumulative reward. In this work, we consider the RL setting where the goal is to optimize the quantile of the cumulative reward. We parameterize the policy controlling…

Machine Learning · Computer Science 2023-05-15 Jinyang Jiang , Jiaqiao Hu , Yijie Peng

Quadratic Unconstrained Binary Optimization (QUBO) is recognized as a unifying framework for modeling a wide range of problems. Problems can be solved with commercial solvers customized for solving QUBO and since QUBO have degree two, it is…

Optimization and Control · Mathematics 2021-07-27 Amit Verma , Mark Lewis , Gary Kochenberger

Feature selection is a machine learning technique for identifying relevant variables in classification and regression models. In single-cell RNA sequencing (scRNA-seq) data analysis, feature selection is used to identify relevant genes that…

Genomics · Quantitative Biology 2025-12-02 Selim Romero , Shreyan Gupta , Victoria Gatlin , Robert S. Chapkin , James J. Cai

Monte Carlo methods play a central role in particle physics, where they are indispensable for simulating scattering processes, modeling detector responses, and performing multi-dimensional integrals. However, traditional Monte Carlo methods…

Quantum Physics · Physics 2025-10-14 Heechan Yi , Kayoung Ban , Myeonghun Park , Kyoungchul Kong