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First-principles atomistic simulations are essential for understanding complex material phenomena but are fundamentally limited by their computational cost. While Machine Learning Interatomic Potentials (MLIPs) have drastically improved…

A structure prediction method is presented based on the Minima Hopping method. Optimized moves on the configurational enthalpy surface are performed to escape local minima using variable cell shape molecular dynamics by aligning the initial…

Materials Science · Physics 2013-07-02 Maximilian Amsler , Stefan Goedecker

In the dynamic field of materials science, the quest to find optimal structures with low potential energy is of great significance. Over the past two decades, the minima hopping algorithm has emerged as a successful tool in this pursuit. We…

We created a computational workflow to analyze the potential energy surface (PES) of materials using machine-learned interatomic potentials in conjunction with the minima hopping algorithm. We demonstrate this method by producing a…

Materials Science · Physics 2025-02-14 Hossein Tahmasbi , Kushal Ramakrishna , Mani Lokamani , Attila Cangi

We present here a fully first-principles method for predicting the atomic structure of interfaces. Our method is based on the {\it ab initio} random structure searching (AIRSS) approach, applied here to treat two dimensional defects. The…

Materials Science · Physics 2014-07-22 Georg Schusteritsch , Chris J. Pickard

Associative memory Hamiltonian structure prediction potentials are not overly rugged, thereby suggesting their landscapes are like those of actual proteins. In the present contribution we show how basin-hopping global optimization can…

Biomolecules · Quantitative Biology 2009-11-13 Michael C. Prentiss , David J. Wales , Peter G. Wolynes

Machine-Learned Interatomic Potentials (MLIPs) require vast amounts of atomic structure data to learn forces and energies, and their performance continues to improve with training set size. Meanwhile, the even greater quantities of…

Chemical Physics · Physics 2025-12-09 Manasa Kaniselvan , Benjamin Kurt Miller , Meng Gao , Juno Nam , Daniel S. Levine

The past decade has witnessed a spectacular development of machine-learned interatomic potentials (MLIPs), to the extent that they are already the approach of choice for most atomistic simulation studies not requiring an explicit treatment…

Materials Science · Physics 2025-11-24 Iñigo Robredo-Magro , Binayak Mukherjee , Hugo Aramberri , Jorge Íñiguez-González

Allegro is a machine learning interatomic potential (MLIP) model designed to predict atomic properties in molecules using E(3) equivariant neural networks. When training this model, there tends to be a trade-off between accuracy and…

Machine Learning Inter-atomic Potentials (MLIPs) have become a common tool in use by computational chemists due to their combination of accuracy and speed. Yet, it is still not clear how well these tools behave at or near transitions states…

Chemical Physics · Physics 2022-11-15 Aaron Philip , Guoqing Zhou , Benjamin Nebgen

An analysis of the network defined by the potential energy minima of multi-atomic systems and their connectivity via reaction pathways that go through transition states allows to understand important characteristics like thermodynamic,…

Materials Science · Physics 2016-08-03 Bastian Schaefer , Stefan Goedecker

Resolving the atomic-scale structure of defective high-entropy alloys (HEAs) containing interstitial species remains a major computational challenge due to the vast configurational space and the limitations of existing methods. Here we…

Materials Science · Physics 2026-03-11 Siya Zhu , Raymundo Arroyave

Adversarial approaches, which intentionally challenge machine learning models by generating difficult examples, are increasingly being adopted to improve machine learning interatomic potentials (MLIPs). While already providing great…

Machine-learned interatomic potentials can offer near first-principles accuracy but are computationally expensive, limiting their application to large-scale molecular dynamics simulations. Inspired by quantum mechanics/molecular mechanics…

Materials Science · Physics 2025-11-21 Fraser Birks , Matthew Nutter , Thomas D Swinburne , James R Kermode

Accurate understanding and control of interfacial adhesion between Cu and Ta$_x$N diffusion barriers are essential for ensuring the mechanical reliability and integrity of Cu interconnect systems in semiconductor devices. Amorphous tantalum…

Materials Science · Physics 2025-09-30 Jeong Min Choi , Jaehoon Kim , Ji-Hwan Lee , Won-Joon Son , Seungwu Han

Using a fast and accurate neural network potential we are able to systematically explore the energy landscape of large unit cells of bulk magnesium oxide with the minima hopping method. The potential is trained with a focus on the…

Materials Science · Physics 2021-09-08 Hossein Tahmasbi , Stefan Goedecker , S. Alireza Ghasemi

Machine learning interatomic potentials (MLIPs) are routinely used to model diverse atomistic phenomena, yet parameterizing them to accurately capture solid-state phase transformations remains difficult. We present error metrics and…

Materials Science · Physics 2026-01-21 Lorenzo Piersante , Anirudh Raju Natarajan

Forming a hetero-interface is a materials-design strategy that can access an astronomically large phase space. However, the immense phase space necessitates a high-throughput approach for optimal interface design. Here we introduce a…

Protein structure prediction is a critical problem linked to drug design, mutation detection, and protein synthesis, among other applications. To this end, evolutionary data has been used to build contact maps which are traditionally…

Biomolecules · Quantitative Biology 2022-11-08 Lakshmi A. Ghantasala , Risi Jaiswal , Supriyo Datta

Accurate crystal structure prediction (CSP) at finite temperatures with quantum anharmonic effects remains challenging but very prominent in systems with lightweight atoms such as superconducting hydrides. In this work, we integrate…

Materials Science · Physics 2026-01-01 Daniil Poletaev , Artem Oganov
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