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Medical imaging is spearheading the AI transformation of healthcare. Performance reporting is key to determine which methods should be translated into clinical practice. Frequently, broad conclusions are simply derived from mean performance…

The use of AI systems in healthcare for the early screening of diseases is of great clinical importance. Deep learning has shown great promise in medical imaging, but the reliability and trustworthiness of AI systems limit their deployment…

Image and Video Processing · Electrical Eng. & Systems 2023-05-17 Ke Zou , Zhihao Chen , Xuedong Yuan , Xiaojing Shen , Meng Wang , Huazhu Fu

Trustworthy artificial intelligence (AI) is essential in healthcare, particularly for high-stakes tasks like medical image segmentation. Explainable AI and uncertainty quantification significantly enhance AI reliability by addressing key…

An important issue in medical image processing is to be able to estimate not only the performances of algorithms but also the precision of the estimation of these performances. Reporting precision typically amounts to reporting…

Computer Vision and Pattern Recognition · Computer Science 2023-05-25 Rosana El Jurdi , Olivier Colliot

Any supervised machine learning analysis is required to provide an estimate of the out-of-sample predictive performance. However, it is imperative to also provide a quantification of the uncertainty of this performance in the form of a…

Machine Learning · Computer Science 2024-06-13 Konstantinos Paraschakis , Andrea Castellani , Giorgos Borboudakis , Ioannis Tsamardinos

The comprehensive integration of machine learning healthcare models within clinical practice remains suboptimal, notwithstanding the proliferation of high-performing solutions reported in the literature. A predominant factor hindering…

Image and Video Processing · Electrical Eng. & Systems 2023-10-12 Ling Huang , Su Ruan , Yucheng Xing , Mengling Feng

When assessing the quality of prediction models in machine learning, confidence intervals (CIs) for the generalization error, which measures predictive performance, are a crucial tool. Luckily, there exist many methods for computing such…

The use of deep learning for medical imaging has seen tremendous growth in the research community. One reason for the slow uptake of these systems in the clinical setting is that they are complex, opaque and tend to fail silently. Outside…

Computer Vision and Pattern Recognition · Computer Science 2018-07-03 Terrance DeVries , Graham W. Taylor

Artificial intelligence (AI) systems accelerate medical workflows and improve diagnostic accuracy in healthcare, serving as second-opinion systems. However, the unpredictability of AI errors poses a significant challenge, particularly in…

Artificial intelligence (AI) models trained using medical images for clinical tasks often exhibit bias in the form of disparities in performance between subgroups. Since not all sources of biases in real-world medical imaging data are…

Computer Vision and Pattern Recognition · Computer Science 2024-07-02 Emma A. M. Stanley , Raissa Souza , Anthony Winder , Vedant Gulve , Kimberly Amador , Matthias Wilms , Nils D. Forkert

Performance comparisons are fundamental in medical imaging Artificial Intelligence (AI) research, often driving claims of superiority based on relative improvements in common performance metrics. However, such claims frequently rely solely…

Medical segmentation models are evaluated empirically. As such an evaluation is based on a limited set of example images, it is unavoidably noisy. Beyond a mean performance measure, reporting confidence intervals is thus crucial. However,…

Image and Video Processing · Electrical Eng. & Systems 2025-03-25 R. El Jurdi , G. Varoquaux , O. Colliot

Artificial Intelligence (AI) has demonstrated potential in healthcare, particularly in enhancing diagnostic accuracy and decision-making through Clinical Decision Support Systems (CDSSs). However, the successful implementation of these…

Human-Computer Interaction · Computer Science 2025-01-29 Olya Rezaeian , Alparslan Emrah Bayrak , Onur Asan

Despite the recent improvements in overall accuracy, deep learning systems still exhibit low levels of robustness. Detecting possible failures is critical for a successful clinical integration of these systems, where each data point…

Image and Video Processing · Electrical Eng. & Systems 2019-10-14 Alain Jungo , Mauricio Reyes

A myriad of measures to illustrate performance of predictive artificial intelligence (AI) models have been proposed in the literature. Selecting appropriate performance measures is essential for predictive AI models that are developed to be…

Data following an interval structure are increasingly prevalent in many scientific applications. In medicine, clinical events are often monitored between two clinical visits, making the exact time of the event unknown and generating…

Methodology · Statistics 2025-04-01 Carlos García Meixide , Michael R. Kosorok , Marcos Matabuena

Performance metrics for medical image segmentation models are used to measure the agreement between the reference annotation and the predicted segmentation. Usually, overlap metrics, such as the Dice, are used as a metric to evaluate the…

Image and Video Processing · Electrical Eng. & Systems 2024-03-26 Sophie Ostmeier , Brian Axelrod , Jeroen Bertels , Fabian Isensee , Maarten G. Lansberg , Soren Christensen , Gregory W. Albers , Li-Jia Li , Jeremy J. Heit

Performance monitoring is essential for safe clinical deployment of image classification models. However, because ground-truth labels are typically unavailable in the target dataset, direct assessment of real-world model performance is…

Machine Learning · Computer Science 2025-07-31 Tim Flühmann , Alceu Bissoto , Trung-Dung Hoang , Lisa M. Koch

Machine learning (ML) models are increasingly used to support clinical decision-making. However, real-world medical datasets are often noisy, incomplete, and imbalanced, leading to performance disparities across patient subgroups. These…

Predictive artificial intelligence (AI) offers an opportunity to improve clinical practice and patient outcomes, but risks perpetuating biases if fairness is inadequately addressed. However, the definition of "fairness" remains unclear. We…

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