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The application of deep learning in medical imaging has significantly advanced diagnostic capabilities, enhancing both accuracy and efficiency. Despite these benefits, the lack of transparency in these AI models, often termed "black boxes,"…

Computer Vision and Pattern Recognition · Computer Science 2024-09-23 Eleonora Beatrice Rossi , Eleonora Lopez , Danilo Comminiello

The Expected Calibration Error (ece), the dominant calibration metric in machine learning, compares predicted probabilities against empirical frequencies of binary outcomes. This is appropriate when labels are binary events. However, many…

Machine Learning · Computer Science 2026-03-17 Michael Leznik

Sophisticated machine models are increasingly used for high-stakes decisions in everyday life. There is an urgent need to develop effective explanation techniques for such automated decisions. Rule-Based Explanations have been proposed for…

Machine Learning · Computer Science 2022-11-01 Zixuan Geng , Maximilian Schleich , Dan Suciu

Machine learning models now influence decisions that directly affect people's lives, making it important to understand not only their predictions, but also how individuals could act to obtain better results. Algorithmic recourse provides…

Machine Learning · Computer Science 2026-02-10 Bohdan Turbal , Iryna Voitsitska , Lesia Semenova

When a machine learning model is deployed, its predictions can alter its environment, as better informed agents strategize to suit their own interests. With such alterations in mind, existing approaches to uncertainty quantification break.…

Machine Learning · Statistics 2024-11-05 Daniel Csillag , Claudio José Struchiner , Guilherme Tegoni Goedert

Uncertainty is critical to reliable decision-making with machine learning. Conformal prediction (CP) handles uncertainty by predicting a set on a test input, hoping the set to cover the true label with at least $(1-\alpha)$ confidence. This…

Machine Learning · Computer Science 2024-03-25 Rui Xu , Yue Sun , Chao Chen , Parv Venkitasubramaniam , Sihong Xie

Despite their enormous predictive power, machine learning models are often unsuitable for applications in regulated industries such as finance, due to their limited capacity to provide explanations. While model-agnostic frameworks such as…

Machine Learning · Statistics 2025-11-03 Joshua S. Harvey , Guanchao Feng , Sai Anusha Meesala , Tina Zhao , Dhagash Mehta

Recent advances in deep learning have improved multivariate time series (MTS) classification and regression by capturing complex patterns, but their lack of transparency hinders decision-making. Explainable AI (XAI) methods offer partial…

Machine Learning · Computer Science 2025-11-25 Alan G. Paredes Cetina , Kaouther Benguessoum , Raoni Lourenço , Sylvain Kubler

Latent-space optimization methods for counterfactual explanations - framed as minimal semantic perturbations that change model predictions - inherit the ambiguity of Wachter et al.'s objective: the choice of distance metric dictates whether…

Machine Learning · Computer Science 2026-03-03 Eslam Zaher , Maciej Trzaskowski , Quan Nguyen , Fred Roosta

Counterfactual explanations for machine learning models are used to find minimal interventions to the feature values such that the model changes the prediction to a different output or a target output. A valid counterfactual explanation…

Machine Learning · Computer Science 2023-03-23 Shravan Kumar Sajja , Sumanta Mukherjee , Satyam Dwivedi

Conformal Prediction (CP) stands out as a robust framework for uncertainty quantification, which is crucial for ensuring the reliability of predictions. However, common CP methods heavily rely on data exchangeability, a condition often…

Counterfactual explanations have emerged as a prominent method in Explainable Artificial Intelligence (XAI), providing intuitive and actionable insights into Machine Learning model decisions. In contrast to other traditional feature…

Stochastic reaction network models are often used to explain and predict the dynamics of gene regulation in single cells. These models usually involve several parameters, such as the kinetic rates of chemical reactions, that are not…

Computation · Statistics 2020-01-07 Thomas A. Catanach , Huy D. Vo , Brian Munsky

Work in Counterfactual Explanations tends to focus on the principle of "the closest possible world" that identifies small changes leading to the desired outcome. In this paper we argue that while this approach might initially seem…

Machine Learning · Computer Science 2020-02-25 Rafael Poyiadzi , Kacper Sokol , Raul Santos-Rodriguez , Tijl De Bie , Peter Flach

We develop scalable methods for producing conformal Bayesian predictive intervals with finite sample calibration guarantees. Bayesian posterior predictive distributions, $p(y \mid x)$, characterize subjective beliefs on outcomes of…

Methodology · Statistics 2021-06-15 Edwin Fong , Chris Holmes

Many researchers and policymakers have expressed excitement about algorithmic explanations enabling more fair and responsible decision-making. However, recent experimental studies have found that explanations do not always improve human use…

Human-Computer Interaction · Computer Science 2022-08-30 Yaniv Yacoby , Ben Green , Christopher L. Griffin , Finale Doshi Velez

Scientific claims gain credibility by replicability, especially if replication under different circumstances and varying designs yields equivalent results. Aggregating results over multiple studies is, however, not straightforward, and when…

Methodology · Statistics 2023-12-27 Thom Benjamin Volker , Irene Klugkist

The imminent need to interpret the output of a Machine Learning model with counterfactual (CF) explanations - via small perturbations to the input - has been notable in the research community. Although the variety of CF examples is…

Machine Learning · Computer Science 2024-04-23 Kleopatra Markou , Dimitrios Tomaras , Vana Kalogeraki , Dimitrios Gunopulos

Modern neural networks achieve strong performance but remain difficult to interpret in high-dimensional visual domains. Counterfactual explanations (CFEs) provide a principled approach to interpreting black-box predictions by identifying…

Machine Learning · Computer Science 2026-03-19 Ahmed Zeid , Sidney Bender

Estimating counterfactual outcomes over time has the potential to unlock personalized healthcare by assisting decision-makers to answer ''what-iF'' questions. Existing causal inference approaches typically consider regular, discrete-time…

Machine Learning · Computer Science 2022-06-17 Nabeel Seedat , Fergus Imrie , Alexis Bellot , Zhaozhi Qian , Mihaela van der Schaar