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Methods for designing organic materials with desired properties have high potential impact across fields such as medicine, renewable energy, petrochemical engineering, and agriculture. However, using generative modeling to design substances…

Machine Learning · Computer Science 2021-08-24 Daniel Rothchild , Alex Tamkin , Julie Yu , Ujval Misra , Joseph Gonzalez

Large Language Models can develop reasoning capabilities through online fine-tuning with rule-based rewards. However, recent studies reveal a critical constraint: reinforcement learning succeeds only when the base model already assigns…

We have generated an open-source dataset of over 30000 organic chemistry gas phase partition functions. With this data, a machine learning deep neural network estimator was trained to predict partition functions of unknown organic chemistry…

Chemical Physics · Physics 2022-03-08 Evan Komp , Stéphanie Valleau

Thomson scattering (TS) diagnostics provide reliable, minimally perturbative measurements of fundamental plasma parameters, such as electron density ($n_e$) and electron temperature ($T_e$). Deep neural networks can provide accurate…

This study address the computational determination of catalytic reaction rates by moving beyond traditional Transition State Theory (TST), addressing its limitations in complex systems. The Hill relation framework, integrated with Adaptive…

Chemical Physics · Physics 2025-11-25 Thomas Pigeon , Manuel Corral Valero , Pascal Raybaud

In recent years, pre-trained large language models have achieved remarkable success across diverse tasks. Besides the pivotal role of self-supervised pre-training, their effectiveness in downstream applications also depends critically on…

Artificial Intelligence · Computer Science 2026-03-04 Qi Zhang , Yifei Wang , Xiaohan Wang , Jiajun Chai , Guojun Yin , Wei Lin , Yisen Wang

The identification and classification of transitions in topological and microstructural regimes in pattern-forming processes are critical for understanding and fabricating microstructurally precise novel materials in many application…

Materials Science · Physics 2022-08-12 Marcin Abram , Keith Burghardt , Greg Ver Steeg , Aram Galstyan , Remi Dingreville

Reliable predictions of the behaviour of chemical systems are essential across many industries, from nanoscale engineering over validation of advanced materials to nanotoxicity assessment in health and medicine. For the future we therefore…

Chemical Physics · Physics 2021-03-05 Judith B. Rommel

Personal robots assisting humans must perform complex manipulation tasks that are typically difficult to specify in traditional motion planning pipelines, where multiple objectives must be met and the high-level context be taken into…

Robotics · Computer Science 2019-03-21 Hejia Zhang , Eric Heiden , Stefanos Nikolaidis , Joseph J. Lim , Gaurav S. Sukhatme

The limited extrapolative power of structure-based machine learning (ML) models is a critical bottleneck in chemical discovery, particularly for industrial R&D, where navigating uncharted chemical space to find next-generation materials or…

The chemical fueling of transient states (CFTS) is a powerful process to control the nonequilibrium structuring and the homeostatic function of adaptive soft matter systems. Here, we introduce a mean-field model of CFTS based on the…

Soft Condensed Matter · Physics 2023-06-12 Sven Pattloch , Joachim Dzubiella

Accurately predicting industrial aging processes makes it possible to schedule maintenance events further in advance, ensuring a cost-efficient and reliable operation of the plant. So far, these degradation processes were usually described…

Machine Learning · Computer Science 2020-10-22 Mihail Bogojeski , Simeon Sauer , Franziska Horn , Klaus-Robert Müller

General-purpose 3D modeling in chemistry encompasses molecules and materials, requiring both generative and predictive capabilities. However, most existing AI approaches are optimized for a single domain (molecules or materials) and a…

Recent progress in machine learning has sparked increased interest in utilizing this technology to predict the outcomes of chemical reactions. The ultimate aim of such endeavors is to develop a universal model that can predict products for…

Chemical Physics · Physics 2025-07-03 Daniel Julian , Jesús Pérez-Ríos

Chemical transformations depend not only on the identities of the reacting species but also on the catalytic, environmental, and intermediate conditions under which they occur. Classical binary reaction formalisms usually treat such…

Transition state theory is a standard framework for predicting the rate of a chemical reaction. Although the transition state theory has been successfully applied to numerous chemical reaction analyses, many experimental and theoretical…

Self-supervised learning has brought about a revolutionary paradigm shift in various computing domains, including NLP, vision, and biology. Recent approaches involve pre-training transformer models on vast amounts of unlabeled data, serving…

Artificial Intelligence · Computer Science 2023-12-05 Raphael Boige , Yannis Flet-Berliac , Arthur Flajolet , Guillaume Richard , Thomas Pierrot

In machine learning, overparameterization is associated with qualitative changes in the empirical risk landscape, which can lead to more efficient training dynamics. For many parameterized models used in statistical learning, there exists a…

Quantum Physics · Physics 2023-07-11 Andrea Delgado , Francisco Rios , Kathleen E. Hamilton

Materials design aims to discover novel compounds with desired properties. However, prevailing strategies face critical trade-offs. Conventional element-substitution approaches readily and adaptively incorporate various domain knowledge but…

Superconductivity · Physics 2025-05-30 Akihiro Fujii , Anh Khoa Augustin Lu , Koji Shimizu , Satoshi Watanabe

A range of generative machine learning models for the design of novel molecules and materials have been proposed in recent years. Models that can generate three-dimensional structures are particularly suitable for quantum chemistry…