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Significant scientific discoveries have driven the progress of human civilisation. The explosion of scientific literature and data has created information barriers across disciplines that have slowed the pace of scientific discovery. Large…

Computation and Language · Computer Science 2023-11-13 Biqing Qi , Kaiyan Zhang , Haoxiang Li , Kai Tian , Sihang Zeng , Zhang-Ren Chen , Bowen Zhou

High-dimensional data remains a pervasive challenge in machine learning, often undermining model interpretability and computational efficiency. While Large Language Models (LLMs) have shown promise for dimensionality reduction through…

Machine Learning · Computer Science 2025-10-08 Mohamed Bal-Ghaoui , Fayssal Sabri

Recent advancements in Large Language Models (LLMs) have led to a rapid growth of agentic systems capable of handling a wide range of complex tasks. However, current research largely relies on manual, task-specific design, limiting their…

Computation and Language · Computer Science 2025-02-28 Yu Shang , Yu Li , Keyu Zhao , Likai Ma , Jiahe Liu , Fengli Xu , Yong Li

Prompt engineering has emerged as a powerful technique for guiding large language models (LLMs) toward desired responses, significantly enhancing their performance across diverse tasks. Beyond their role as static predictors, LLMs…

Machine Learning · Computer Science 2025-03-27 Ryumei Nakada , Wenlong Ji , Tianxi Cai , James Zou , Linjun Zhang

Autonomous science agents built on large language models (LLMs) are increasingly used to generate hypotheses, design experiments, and produce reports. However, prior work mainly targets open-ended scientific problems with subjective outputs…

Computation and Language · Computer Science 2026-03-24 Tianshu Zhang , Huan Sun

Complex chemical space and limited knowledge scope with biases holds immense challenge for human scientists, yet in automated materials discovery. Existing intelligent methods relies more on numerical computation, leading to inefficient…

Machine Learning · Computer Science 2025-04-15 Zheyuan Lai , Yingming Pu

People commonly leverage structured content to accelerate knowledge acquisition and research problem solving. Among these, roadmaps guide researchers through hierarchical subtasks to solve complex research problems step by step. Despite…

Computation and Language · Computer Science 2026-05-01 Jiacheng Liu , Zichen Tang , Zhongjun Yang , Xinyi Hu , Xueyuan Lin , Linwei Jia , Ruofei Bai , Rongjin Li , Shiyao Peng , Haocheng Gao , Haihong E

The generation of molecules with Artificial Intelligence (AI) is poised to revolutionize materials discovery. Potential applications range from development of potent drugs to efficient carbon capture and separation technologies. However,…

Active learning (AL) accelerates scientific discovery by prioritizing the most informative experiments, but traditional machine learning (ML) models used in AL suffer from cold-start limitations and domain-specific feature engineering,…

Machine Learning · Computer Science 2025-12-05 Hongchen Wang , Rafael Espinosa Castañeda , Jay R. Werber , Yao Fehlis , Edward Kim , Jason Hattrick-Simpers

Machine learning (ML) offers a powerful path toward discovering sustainable polymer materials, but progress has been limited by the lack of large, high-quality, and openly accessible polymer datasets. The Open Polymer Challenge (OPC)…

There has been rapidly growing demand of polymeric materials coming from different aspects of modern life because of the highly diverse physical and chemical properties of polymers. Polymer informatics is an interdisciplinary research field…

Soft Condensed Matter · Physics 2020-10-16 Stephen Wu , Hironao Yamada , Yoshihiro Hayashi , Massimiliano Zamengo , Ryo Yoshida

Autonomous agents have long been a prominent research focus in both academic and industry communities. Previous research in this field often focuses on training agents with limited knowledge within isolated environments, which diverges…

Artificial Intelligence · Computer Science 2025-03-04 Lei Wang , Chen Ma , Xueyang Feng , Zeyu Zhang , Hao Yang , Jingsen Zhang , Zhiyuan Chen , Jiakai Tang , Xu Chen , Yankai Lin , Wayne Xin Zhao , Zhewei Wei , Ji-Rong Wen

The synthesis of inorganic crystalline materials is essential for modern technology, especially in quantum materials development. However, designing efficient synthesis workflows remains a significant challenge due to the precise…

The discovery of novel Ionic Liquids (ILs) is hindered by critical challenges in property prediction, including limited data, poor model accuracy, and fragmented workflows. Leveraging the power of Large Language Models (LLMs), we introduce…

Artificial Intelligence · Computer Science 2025-11-17 Yuqi Yin , Yibo Fu , Siyuan Wang , Peng Sun , Hongyu Wang , Xiaohui Wang , Lei Zheng , Zhiyong Li , Zhirong Liu , Jianji Wang , Zhaoxi Sun

Large language models (LLMs) can already identify patterns and reason effectively, yet their variable accuracy hampers adoption in high-stakes decision-making applications. In this paper, we study this issue from a venture capital…

Artificial Intelligence · Computer Science 2025-10-28 Rick Chen , Joseph Ternasky , Aaron Ontoyin Yin , Xianling Mu , Fuat Alican , Yigit Ihlamur

Significant advancements have occurred in the application of Large Language Models (LLMs) for social simulations. Despite this, their abilities to perform teaming in task-oriented social events are underexplored. Such capabilities are…

Artificial Intelligence · Computer Science 2025-08-18 Yuan Li , Lichao Sun , Yixuan Zhang

Large language models (LLMs), renowned for their powerful conversational abilities, are widely recognized as exceptional tools in the field of education, particularly in the context of automated intelligent instruction systems for language…

Computation and Language · Computer Science 2024-07-19 Kaiqi Fu , Linkai Peng , Nan Yang , Shuran Zhou

Transformer-based language models (LMs) continue to achieve state-of-the-art performance on natural language processing (NLP) benchmarks, including tasks designed to mimic human-inspired "commonsense" competencies. To better understand the…

Computation and Language · Computer Science 2022-05-13 Antonio Laverghetta , Animesh Nighojkar , Jamshidbek Mirzakhalov , John Licato

Designing de novo proteins beyond those found in nature holds significant promise for advancements in both scientific and engineering applications. Current methodologies for protein design often rely on AI-based models, such as surrogate…

Soft Condensed Matter · Physics 2024-02-08 A. Ghafarollahi , M. J. Buehler

The success of language models, especially transformer-based architectures, has trickled into other domains giving rise to "scientific language models" that operate on small molecules, proteins or polymers. In chemistry, language models…

Chemical Physics · Physics 2024-10-22 Nikita Janakarajan , Tim Erdmann , Sarath Swaminathan , Teodoro Laino , Jannis Born
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