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Related papers: Latent Causal Diffusions for Single-Cell Perturbat…

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This paper introduces the Single-Cell Perturbation Prediction Diffusion Model (scPPDM), the first diffusion-based framework for single-cell drug-response prediction from scRNA-seq data. scPPDM couples two condition channels,…

Quantitative Methods · Quantitative Biology 2025-10-15 Zhaokang Liang , Shuyang Zhuang , Xiaoran Jiao , Weian Mao , Hao Chen , Chunhua Shen

Score-based generative models (SGMs) have demonstrated remarkable synthesis quality. SGMs rely on a diffusion process that gradually perturbs the data towards a tractable distribution, while the generative model learns to denoise. The…

Machine Learning · Statistics 2022-03-28 Tim Dockhorn , Arash Vahdat , Karsten Kreis

Recent works have shown the potential of diffusion models in computer vision and natural language processing. Apart from the classical supervised learning fields, diffusion models have also shown strong competitiveness in reinforcement…

Machine Learning · Computer Science 2023-06-09 Jifeng Hu , Yanchao Sun , Sili Huang , SiYuan Guo , Hechang Chen , Li Shen , Lichao Sun , Yi Chang , Dacheng Tao

Understanding climate dynamics requires going beyond correlations in observational data to uncover their underlying causal process. Latent drivers, such as atmospheric processes, play a critical role in temporal dynamics, while direct…

Machine Learning · Computer Science 2025-10-10 Minghao Fu , Biwei Huang , Zijian Li , Yujia Zheng , Ignavier Ng , Guangyi Chen , Yingyao Hu , Kun Zhang

Causal discovery for both cross-sectional and temporal data has traditionally followed a dataset-specific paradigm, where a new model is fitted for each individual dataset. Such an approach limits the potential of multi-dataset pretraining.…

We consider the problem of predicting perturbation effects via causal models. In many applications, it is a priori unknown which mechanisms of a system are modified by an external perturbation, even though the features of the perturbation…

Machine Learning · Computer Science 2025-07-02 Nora Schneider , Lars Lorch , Niki Kilbertus , Bernhard Schölkopf , Andreas Krause

Text-to-image diffusion models have demonstrated remarkable effectiveness in rapid and high-fidelity personalization, even when provided with only a few user images. However, the effectiveness of personalization techniques has lead to…

Computer Vision and Pattern Recognition · Computer Science 2025-10-06 Naresh Kumar Devulapally , Shruti Agarwal , Tejas Gokhale , Vishnu Suresh Lokhande

Data-driven deep learning models have enabled tremendous progress in change detection (CD) with the support of pixel-level annotations. However, collecting diverse data and manually annotating them is costly, laborious, and…

Computer Vision and Pattern Recognition · Computer Science 2024-12-23 Qi Zang , Jiayi Yang , Shuang Wang , Dong Zhao , Wenjun Yi , Zhun Zhong

This paper investigates causal effect identification in latent variable Linear Non-Gaussian Acyclic Models (lvLiNGAM) using higher-order cumulants, addressing two prominent setups that are challenging in the presence of latent confounding:…

Machine Learning · Statistics 2025-06-09 Daniele Tramontano , Yaroslav Kivva , Saber Salehkaleybar , Mathias Drton , Negar Kiyavash

Video Anomaly Detection (VAD) remains a fundamental yet formidable task in the video understanding community, with promising applications in areas such as information forensics and public safety protection. Due to the rarity and diversity…

Computer Vision and Pattern Recognition · Computer Science 2025-03-25 Yang Liu , Hongjin Wang , Zepu Wang , Xiaoguang Zhu , Jing Liu , Peng Sun , Rui Tang , Jianwei Du , Victor C. M. Leung , Liang Song

Recently in the field of unsupervised representation learning, strong identifiability results for disentanglement of causally-related latent variables have been established by exploiting certain side information, such as class labels, in…

Machine Learning · Computer Science 2022-10-26 Weiran Yao , Guangyi Chen , Kun Zhang

Adapting text-to-image (T2I) latent diffusion models (LDMs) to video editing has shown strong visual fidelity and controllability, but challenges remain in maintaining causal relationships inherent to the video data generating process.…

Computer Vision and Pattern Recognition · Computer Science 2025-08-06 Nikos Spyrou , Athanasios Vlontzos , Paraskevas Pegios , Thomas Melistas , Nefeli Gkouti , Yannis Panagakis , Giorgos Papanastasiou , Sotirios A. Tsaftaris

Although autoregressive models have dominated language modeling in recent years, there has been a growing interest in exploring alternative paradigms to the conventional next-token prediction framework. Diffusion-based language models have…

Computation and Language · Computer Science 2025-10-23 Chihan Huang , Hao Tang

Diffusion models for continuous data gained widespread adoption owing to their high quality generation and control mechanisms. However, controllable diffusion on discrete data faces challenges given that continuous guidance methods do not…

Causal representation learning aims to unveil latent high-level causal representations from observed low-level data. One of its primary tasks is to provide reliable assurance of identifying these latent causal models, known as…

Machine Learning · Computer Science 2024-12-02 Yuhang Liu , Zhen Zhang , Dong Gong , Mingming Gong , Biwei Huang , Anton van den Hengel , Kun Zhang , Javen Qinfeng Shi

We argue that diffusion models' success in modeling complex distributions is, for the most part, coming from their input conditioning. This paper investigates the representation used to condition diffusion models from the perspective that…

Computer Vision and Pattern Recognition · Computer Science 2026-01-07 Samuel Lavoie , Michael Noukhovitch , Aaron Courville

Latent diffusion models (LDMs) exhibit an impressive ability to produce realistic images, yet the inner workings of these models remain mysterious. Even when trained purely on images without explicit depth information, they typically output…

Computer Vision and Pattern Recognition · Computer Science 2023-11-07 Yida Chen , Fernanda Viégas , Martin Wattenberg

While diffusion-based models have shown remarkable generative capabilities in static settings, their extension to continual learning (CL) scenarios remains fundamentally constrained by Generative Catastrophic Forgetting (GCF). We observe…

Machine Learning · Computer Science 2025-08-25 Jingren Liu , Shuning Xu , Yun Wang , Zhong Ji , Xiangyu Chen

Causal learning has long concerned itself with the accurate recovery of underlying causal mechanisms. Such causal modelling enables better explanations of out-of-distribution data. Prior works on causal learning assume that the high-level…

Spatial profiling technologies in biology, such as imaging mass cytometry (IMC) and spatial transcriptomics (ST), generate high-dimensional, multi-channel data with strong spatial alignment and complex inter-channel relationships.…

Machine Learning · Computer Science 2025-07-08 Haoran Zhang , Mingyuan Zhou , Wesley Tansey