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We propose an automatic 3D segmentation algorithm for multiphoton microscopy images of microglia. Our method is capable of segmenting tubular and blob-like structures from noisy images. Current segmentation techniques and software fail to…

Image and Video Processing · Electrical Eng. & Systems 2018-02-13 Tiffany Ly , Jeremy Thompson , Tajie Harris , Scott T. Acton

Quantitative analysis of the dynamics of tiny cellular and sub-cellular structures, known as particles, in time-lapse cell microscopy sequences requires the development of a reliable multi-target tracking method capable of tracking numerous…

Computer Vision and Pattern Recognition · Computer Science 2015-07-24 Seyed Hamid Rezatofighi , Stephen Gould , Ba Tuong Vo , Ba-Ngu Vo , Katarina Mele , Richard Hartley

Curvilinear structure segmentation is important in medical imaging, quantifying structures such as vessels, airways, neurons, or organ boundaries in 2D slices. Segmentation via pixel-wise classification often fails to capture the small and…

Image and Video Processing · Electrical Eng. & Systems 2023-03-07 Manxi Lin , Zahra Bashir , Martin Grønnebæk Tolsgaard , Anders Nymark Christensen , Aasa Feragen

Significant progress has been made for estimating optical flow using deep neural networks. Advanced deep models achieve accurate flow estimation often with a considerable computation complexity and time-consuming training processes. In this…

Computer Vision and Pattern Recognition · Computer Science 2020-06-23 Lingtong Kong , Jie Yang

The automated segmentation and tracking of macrophages during their migration are challenging tasks due to their dynamically changing shapes and motions. This paper proposes a new algorithm to achieve automatic cell tracking in time-lapse…

Image and Video Processing · Electrical Eng. & Systems 2023-01-03 Seol Ah Park , Tamara Sipka , Zuzana Kriva , George Lutfalla , Mai Nguyen-Chi , Karol Mikula

A reliable extraction of filament data from microscopic images is of high interest in the analysis of acto-myosin structures as early morphological markers in mechanically guided differentiation of human mesenchymal stem cells and the…

Computer Vision and Pattern Recognition · Computer Science 2015-07-15 Benjamin Eltzner , Carina Wollnik , Carsten Gottschlich , Stephan Huckemann , Florian Rehfeldt

Deep generative models provide a promising approach to de novo 3D peptide design. Most of them jointly model the distributions of peptide's position, orientation, and conformation, attempting to simultaneously converge to the target pocket.…

Quantitative Methods · Quantitative Biology 2025-11-04 Dengdeng Huang , Shikui Tu

Flow-matching models have enabled high-quality text-to-speech synthesis, but their iterative sampling process during inference incurs substantial computational cost. Although distillation is widely used to reduce the number of inference…

Sound · Computer Science 2026-02-11 Bin Lin , Peng Yang , Chao Yan , Xiaochen Liu , Wei Wang , Boyong Wu , Pengfei Tan , Xuerui Yang

Generative models have achieved remarkable progress with the emergence of flow matching (FM). It has demonstrated strong generative capabilities and attracted significant attention as a simulation-free flow-based framework capable of…

Computer Vision and Pattern Recognition · Computer Science 2026-04-01 Huynh Trinh Ngoc , Hoang Anh Nguyen Kim , Toan Nguyen Hai , Long Tran Quoc

Accurate and high-resolution precipitation nowcasting from radar echo sequences is crucial for disaster mitigation and economic planning, yet it remains a significant challenge. Key difficulties include modeling complex multi-scale…

Computer Vision and Pattern Recognition · Computer Science 2026-04-20 Wenjie Luo , Chuanhu Deng , Chaorong Li , Rongyao Deng , Qiang Yang

Recently, Flow Matching models have pushed the boundaries of high-fidelity data generation across a wide range of domains. It typically employs a single large network to learn the entire generative trajectory from noise to data. Despite…

Computer Vision and Pattern Recognition · Computer Science 2025-10-27 Dogyun Park , Taehoon Lee , Minseok Joo , Hyunwoo J. Kim

Accurate segmentation of the blood vessels of the retina is an important step in clinical diagnosis of ophthalmic diseases. Many deep learning frameworks have come up for retinal blood vessels segmentation tasks. However, the complex…

Image and Video Processing · Electrical Eng. & Systems 2022-04-08 Ting Zhang , Jun Li , Yi Zhao , Nan Chen , Han Zhou , Hongtao Xu , Zihao Guan , Changcai Yang , Lanyan Xue , Riqing Chen , Lifang Wei

Inferring trajectories from longitudinal spatially-resolved omics data is fundamental to understanding the dynamics of structural and functional tissue changes in development, regeneration and repair, disease progression, and response to…

Machine Learning · Computer Science 2026-05-15 Santanu Subhash Rathod , Francesco Ceccarelli , Sean B. Holden , Pietro Liò , Xiao Zhang , Jovan Tanevski

As the frontline data for cancer diagnosis, microscopic pathology images are fundamental for providing patients with rapid and accurate treatment. However, despite their practical value, the deep learning community has largely overlooked…

Computer Vision and Pattern Recognition · Computer Science 2025-06-23 Sungrae Hong , Hyeongmin Park , Youngsin Ko , Sol Lee , Bryan Wong , Mun Yong Yi

Dense annotations, such as segmentation masks, are expensive and time-consuming to obtain, especially for 3D medical images where expert voxel-wise labeling is required. Weakly supervised approaches aim to address this limitation, but often…

Computer Vision and Pattern Recognition · Computer Science 2026-04-21 Richard Petersen , Fredrik Kahl , Jennifer Alvén

Deploying pretrained visual models in real-world environments often suffers from significant performance degradation due to the diversity of testing scenarios. Continuous adaptation of learning models on edge devices via unlabeled data…

Neural and Evolutionary Computing · Computer Science 2026-05-08 Jianming Lv , Chengjun Wang , Depin Liang , Qianli Ma , Wei Chen , Xueqi Cheng

Accurate segmentation of tubular and curvilinear structures, such as blood vessels, neurons, and road networks, is crucial in various applications. A key challenge is ensuring topological correctness while maintaining computational…

Image and Video Processing · Electrical Eng. & Systems 2025-03-21 Siyi Wu , Leyi Zhao , Haotian Ma , Xinyuan Song

Current discriminative depth estimation methods often produce blurry artifacts, while generative approaches suffer from slow sampling due to curvatures in the noise-to-depth transport. Our method addresses these challenges by framing depth…

Computer Vision and Pattern Recognition · Computer Science 2024-12-20 Ming Gui , Johannes Schusterbauer , Ulrich Prestel , Pingchuan Ma , Dmytro Kotovenko , Olga Grebenkova , Stefan Andreas Baumann , Vincent Tao Hu , Björn Ommer

Vessel segmentation in fundus is a key diagnostic capability in ophthalmology, and there are various challenges remained in this essential task. Early approaches indicate that it is often difficult to obtain desirable segmentation…

Computer Vision and Pattern Recognition · Computer Science 2020-01-17 Shaoming Zheng , Tianyang Zhang , Jiawei Zhuang , Hao Wang , Jiang Liu

Remote sensing segmentation in real deployment is inherently continual: new semantic categories emerge, and acquisition conditions shift across seasons, cities, and sensors. Despite recent progress, many incremental approaches still treat…

Computer Vision and Pattern Recognition · Computer Science 2026-05-19 Jiekai Wu , Rong Fu , Chuangqi Li , Zijian Zhang , Guangxin Wu , Hao Zhang , Shiyin Lin , Jianyuan Ni , Yang Li , Dongxu Zhang , Amir H. Gandomi , Simon Fong , Pengbin Feng