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Statistical matching is an effective method for estimating causal effects in which treated units are paired with control units with ``similar'' values of confounding covariates prior to performing estimation. In this way, matching helps…

Methodology · Statistics 2023-09-13 Sanjeewani Weerasingha , Michael J. Higgins

Concerns over reproducibility in science extend to research using existing healthcare data; many observational studies investigating the same topic produce conflicting results, even when using the same data. To address this problem, we…

Applications · Statistics 2018-03-30 Martijn J. Schuemie , Patrick B. Ryan , George Hripcsak , David Madigan , Marc A. Suchard

Background: Patient-reported survey data are used to train prognostic models aimed at improving healthcare. However, such data are typically available multi-centric and, for privacy reasons, cannot easily be centralized in one data…

Data normalization is a crucial preprocessing step for enhancing model performance and training stability. In federated learning (FL), where data remains distributed across multiple parties during collaborative model training, normalization…

Cryptography and Security · Computer Science 2025-11-17 Melih Coşğun , Mert Gençtürk , Sinem Sav

Data heterogeneity is one of the most challenging issues in federated learning, which motivates a variety of approaches to learn personalized models for participating clients. One such approach in deep neural networks based tasks is…

Machine Learning · Computer Science 2023-06-22 Jian Xu , Xinyi Tong , Shao-Lun Huang

The desire to train complex machine learning algorithms and to increase the statistical power in association studies drives neuroimaging research to use ever-larger datasets. The most obvious way to increase sample size is by pooling scans…

Computer Vision and Pattern Recognition · Computer Science 2020-10-29 Christian Wachinger , Anna Rieckmann , Sebastian Pölsterl

Personalized medication aims to tailor healthcare to individual patient characteristics. However, the heterogeneity of patient data across healthcare systems presents significant challenges to achieving accurate and effective personalized…

Artificial Intelligence · Computer Science 2024-12-10 Jiechao Gao , Yuangang Li

As the sequencing costs are decreasing, there is great incentive to perform large scale association studies to increase power of detecting new variants. Federated association testing among different institutions is a viable solution for…

Methodology · Statistics 2022-10-04 Wentao Li , Han Chen , Xiaoqian Jiang , Arif Harmanci

Block-Term Tensor Regression (BTTR) has proven to be a powerful tool for modeling complex, high-dimensional data by leveraging multilinear relationships, making it particularly well-suited for applications in healthcare and neuroscience.…

Machine Learning · Computer Science 2024-12-11 Axel Faes , Ashkan Pirmani , Yves Moreau , Liesbet M. Peeters

Federated learning enables the creation of a powerful centralized model without compromising data privacy of multiple participants. While successful, it does not incorporate the case where each participant independently designs its own…

Machine Learning · Computer Science 2019-10-10 Daliang Li , Junpu Wang

This article investigates the model-robustness of fixed-effects models for analyzing a broad class of longitudinal cluster trials (CTs) such as stepped-wedge, parallel-with-baseline and crossover designs, encompassing both randomized (CRTs)…

Methodology · Statistics 2026-04-10 Kenneth M. Lee , Fan Li

Federated learning (FL) has been proposed as a method to train a model on different units without exchanging data. This offers great opportunities in the healthcare sector, where large datasets are available but cannot be shared to ensure…

Machine Learning · Computer Science 2022-04-21 Arash Mehrjou , Ashkan Soleymani , Annika Buchholz , Jürgen Hetzel , Patrick Schwab , Stefan Bauer

The Predictive Approaches to Treatment Effect Heterogeneity statement focused on baseline risk as a robust predictor of treatment effect and provided guidance on risk-based assessment of treatment effect heterogeneity in the RCT setting.…

Machine learning models hold significant potential for predicting in-hospital mortality, yet data privacy constraints and the statistical heterogeneity of real-world clinical data often hamper their development. Federated Learning (FL)…

Machine Learning · Computer Science 2025-11-18 Rodrigo Tertulino

As AI evolves, collaboration among heterogeneous models helps overcome data scarcity by enabling knowledge transfer across institutions and devices. Traditional Federated Learning (FL) only supports homogeneous models, limiting…

Machine Learning · Computer Science 2025-06-05 Jianqing Zhang , Xinghao Wu , Yanbing Zhou , Xiaoting Sun , Qiqi Cai , Yang Liu , Yang Hua , Zhenzhe Zheng , Jian Cao , Qiang Yang

Suppose one is interested in estimating causal effects in the presence of potentially unmeasured confounding with the aid of a valid instrumental variable. This paper investigates the problem of making inferences about the average treatment…

Methodology · Statistics 2020-12-15 BaoLuo Sun , Wang Miao

In healthcare prediction tasks, it is essential to exploit the correlations between medical features and learn better patient health representations. Existing methods try to estimate feature correlations only from data, or increase the…

Machine Learning · Computer Science 2022-05-24 Xinyu Ma , Xu Chu , Yasha Wang , Hailong Yu , Liantao Ma , Wen Tang , Junfeng Zhao

This paper presents a novel approach to enhance communication efficiency in federated learning through clipped uniform quantization. By leveraging optimal clipping thresholds and client-specific adaptive quantization schemes, the proposed…

Machine Learning · Computer Science 2024-12-17 Zavareh Bozorgasl , Hao Chen

Federated learning aims to collaboratively train models without accessing their client's local private data. The data may be Non-IID for different clients and thus resulting in poor performance. Recently, personalized federated learning…

Machine Learning · Computer Science 2023-02-16 Dui Wang , Li Shen , Yong Luo , Han Hu , Kehua Su , Yonggang Wen , Dacheng Tao

Federated learning has attracted considerable interest for collaborative machine learning in healthcare to leverage separate institutional datasets while maintaining patient privacy. However, additional challenges such as poor calibration…

Machine Learning · Computer Science 2022-01-19 Charles Lu , Jayasheree Kalpathy-Cramer