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Clinical Reasoning on Electronic Health Records (EHRs) is a fundamental yet challenging task in modern healthcare. While in-context learning (ICL) offers a promising inference-time adaptation paradigm for large language models (LLMs) in EHR…

Machine Learning · Computer Science 2026-04-09 Yue Fang , Weibin Liao , Yuxin Guo , Jiaran Gao , Hongxin Ding , Jinyang Zhang , Xinke Jiang , Zhibang Yang , Junfeng Zhao , Yasha Wang , Liantao Ma

Medical reasoning models remain constrained by parametric knowledge and are thus susceptible to forgetting and hallucinations. DeepResearch (DR) models ground outputs in verifiable evidence from tools and perform strongly in general…

Artificial Intelligence · Computer Science 2026-02-05 Zihan Wang , Hao Wang , Shi Feng , Xiaocui Yang , Daling Wang , Yiqun Zhang , Jinghao Lin , Haihua Yang , Xiaozhong Ji

Recent advancements in Large Language Models (LLMs) have demonstrated significant promise in clinical diagnosis. However, current models struggle to emulate the iterative, diagnostic hypothesis-driven reasoning of real clinical scenarios.…

Computation and Language · Computer Science 2026-01-06 Qipeng Wang , Rui Sheng , Yafei Li , Huamin Qu , Yushi Sun , Min Zhu

Multimodal Large Language Models are increasingly applied to biomedical imaging, yet scientific reasoning for microscopy remains limited by the scarcity of large-scale, high-quality training data. We introduce MicroVQA++, a three-stage,…

Computer Vision and Pattern Recognition · Computer Science 2025-11-17 Manyu Li , Ruian He , Chenxi Ma , Weimin Tan , Bo Yan

Multi-step retrieval-augmented generation (RAG) has become a widely adopted strategy for enhancing large language models (LLMs) on tasks that demand global comprehension and intensive reasoning. Although many RAG systems incorporate a…

Computation and Language · Computer Science 2026-05-28 Chulun Zhou , Chunkang Zhang , Guoxin Yu , Fandong Meng , Jie Zhou , Wai Lam , Mo Yu

Electronic health record (EHR) systems present clinicians with vast repositories of clinical information, creating a significant cognitive burden where critical details are easily overlooked. While Large Language Models (LLMs) offer…

Computation and Language · Computer Science 2026-03-17 Samuel Thio , Matthew Lewis , Spiros Denaxas , Richard JB Dobson

Diagnosing hepatic diseases accurately and interpretably is critical, yet it remains challenging in real-world clinical settings. Existing AI approaches for clinical diagnosis often lack transparency, structured reasoning, and…

Artificial Intelligence · Computer Science 2026-03-06 Zheng Li , Jiayi Xu , Zhikai Hu , Hechang Chen , Lele Cong , Yunyun Wang , Shuchao Pang

Modern scientific discovery faces growing challenges in integrating vast and heterogeneous knowledge critical to breakthroughs in biomedicine and drug development. Traditional hypothesis-driven research, though effective, is constrained by…

Human-Computer Interaction · Computer Science 2025-07-24 Haoran Jiang , Shaohan Shi , Yunjie Yao , Chang Jiang , Quan Li

Artificial intelligence (AI) is reshaping modern healthcare by advancing disease diagnosis, treatment decision-making, and biomedical research. Among AI technologies, large language models (LLMs) have become especially impactful, enabling…

Artificial Intelligence · Computer Science 2025-11-18 Zhengda Wang , Daqian Shi , Jingyi Zhao , Xiaolei Diao , Xiongfeng Tang , Yanguo Qin

Despite the growing use of Electronic Health Records (EHR) for AI-assisted diagnosis prediction, most data-driven models struggle to incorporate clinically meaningful medical knowledge. They often rely on limited ontologies, lacking…

Machine Learning · Computer Science 2025-04-17 Pengfei Hu , Chang Lu , Fei Wang , Yue Ning

Electronic Health Records (EHRs) and routine documentation practices play a vital role in patients' daily care, providing a holistic record of health, diagnoses, and treatment. However, complex and verbose EHR narratives overload healthcare…

Computation and Language · Computer Science 2025-02-26 Yanjun Gao , Ruizhe Li , Emma Croxford , John Caskey , Brian W Patterson , Matthew Churpek , Timothy Miller , Dmitriy Dligach , Majid Afshar

Dermatological care via telemedicine often lacks the rich context of in-person visits. Clinicians must make diagnoses based on a handful of images and brief descriptions, without the benefit of physical exams, second opinions, or reference…

Artificial Intelligence · Computer Science 2025-08-27 Karishma Thakrar , Shreyas Basavatia , Akshay Daftardar

The integration of multimodal Electronic Health Records (EHR) data has significantly improved clinical predictive capabilities. Leveraging clinical notes and multivariate time-series EHR, existing models often lack the medical context…

Artificial Intelligence · Computer Science 2024-02-13 Yinghao Zhu , Changyu Ren , Shiyun Xie , Shukai Liu , Hangyuan Ji , Zixiang Wang , Tao Sun , Long He , Zhoujun Li , Xi Zhu , Chengwei Pan

Knowledge-based visual question answering (QA) aims to answer a question which requires visually-grounded external knowledge beyond image content itself. Answering complex questions that require multi-hop reasoning under weak supervision is…

Computer Vision and Pattern Recognition · Computer Science 2022-04-25 Yu-Jung Heo , Eun-Sol Kim , Woo Suk Choi , Byoung-Tak Zhang

While Retrieval-Augmented Generation (RAG) augments Large Language Models (LLMs) with external knowledge, conventional single-agent RAG remains fundamentally limited in resolving complex queries demanding coordinated reasoning across…

Computation and Language · Computer Science 2025-04-18 Pei Liu , Xin Liu , Ruoyu Yao , Junming Liu , Siyuan Meng , Ding Wang , Jun Ma

Multi-hop question answering (MHQA) requires integrating knowledge scattered across multiple passages to derive the correct answer. Traditional retrieval-augmented generation (RAG) methods primarily focus on coarse-grained textual semantic…

Computation and Language · Computer Science 2025-08-18 Changjian Wang , Weihong Deng , Weili Guan , Quan Lu , Ning Jiang

Multi-hop reasoning (MHR) is a process in artificial intelligence and natural language processing where a system needs to make multiple inferential steps to arrive at a conclusion or answer. In the context of knowledge graphs or databases,…

Artificial Intelligence · Computer Science 2024-06-13 Jesmin Jahan Tithi , Fabio Checconi , Fabrizio Petrini

Medical vision-language models (VLMs) and AI agents have made significant progress in learning to analyze and reason about clinical images. However, existing medical visual question answering (VQA) benchmarks collapse model capabilities…

Computer Vision and Pattern Recognition · Computer Science 2026-05-12 Yixiong Chen , Wenjie Xiao , Pedro R. A. S. Bassi , Boyan Wang , Liang He , Xinze Zhou , Sezgin Er , Ibrahim Ethem Hamamci , Zongwei Zhou , Alan Yuille

Recent developments in Large Language Model (LLM)-based agents have shown impressive capabilities spanning multiple domains, exemplified by deep research systems that demonstrate superior performance on complex information-seeking and…

Computation and Language · Computer Science 2025-09-03 Ailing Yu , Lan Yao , Jingnan Liu , Zhe Chen , Jiajun Yin , Yuan Wang , Xinhao Liao , Zhiling Ye , Ji Li , Yun Yue , Hansong Xiao , Hualei Zhou , Chunxiao Guo , Peng Wei , Junwei Liu , Jinjie Gu

Deep learning has brought significant progress to medical image classification, yet most existing methods still rely on isolated visual evidence and cannot effectively leverage similar cases or external knowledge. In clinical practice,…

Computer Vision and Pattern Recognition · Computer Science 2026-05-28 Yiming Xu , Yixuan Liu , Yuhang Zhang , Ling Zheng , Yihan Wang , Qi Song
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