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Materials discovery is decisive for tackling urgent challenges related to energy, the environment, health care and many others. In chemistry, conventional methodologies for innovation usually rely on expensive and incremental strategies to…

Machine Learning · Computer Science 2020-06-09 Daniel Schwalbe-Koda , Rafael Gómez-Bombarelli

We introduce the first principled framework, Lumos, for specifying and formally certifying Language Model System (LMS) behaviors. Lumos is an imperative probabilistic programming DSL over graphs, with constructs to generate independent and…

Programming Languages · Computer Science 2026-04-02 Isha Chaudhary , Vedaant Jain , Prineet Parhar , Kavya Sachdeva , Avaljot Singh , Sayan Ranu , Gagandeep Singh

Recovering pixel-wise geometric properties from a single image is fundamentally ill-posed due to appearance ambiguity and non-injective mappings between 2D observations and 3D structures. While discriminative regression models achieve…

Computer Vision and Pattern Recognition · Computer Science 2026-05-19 Jing He , Haodong Li , Mingzhi Sheng , Ying-Cong Chen

A supervised machine learning (ML) based computational methodology for the design of particulate multifunctional composite materials with desired thermal conductivity (TC) is presented. The design variables are physical descriptors of the…

Computational Physics · Physics 2025-07-25 Mohammad Saber Hashemi , Masoud Safdari , Azadeh Sheidaei

The discovery of molecules with tailored optoelectronic properties such as specific frequency and intensity of absorption or emission is a major challenge in creating next-generation organic light-emitting diodes (OLEDs) and photovoltaics.…

Chemical Physics · Physics 2022-04-27 James David Green , Eric Gabriel Fuemmeler , Timothy J. H. Hele

Discovering new physical products and processes often demands enormous experimentation and expensive simulation. To design a new product with certain target characteristics, an extensive search is performed in the design space by trying out…

Machine Learning · Statistics 2018-11-16 Phuoc Nguyen , Truyen Tran , Sunil Gupta , Santu Rana , Svetha Venkatesh

Infrared spectroscopy enables rapid, non destructive analysis of chemical and material properties, yet high dimensional signals and overlapping bands hinder conventional chemometric methods. Large language models (LLMs), with strong…

Artificial Intelligence · Computer Science 2025-09-03 Zujie Xie , Zixuan Chen , Jiheng Liang , Xiangyang Yu , Ziru Yu

Geometric representation-conditioned molecule generation provides an effective paradigm that decouples molecule representation modeling from structure generation. By decoupling molecule generation into two stages-first generating a…

Machine Learning · Computer Science 2026-05-11 Shaoheng Yan , Zian Li , Cai Zhou , Qiaojing Huang , Kai Liu , Muhan Zhang

Ultra-Wide-Field Fluorescein Angiography (UWF-FA) enables precise identification of ocular diseases using sodium fluorescein, which can be potentially harmful. Existing research has developed methods to generate UWF-FA from Ultra-Wide-Field…

Computer Vision and Pattern Recognition · Computer Science 2024-09-04 Zhaojie Fang , Xiao Yu , Guanyu Zhou , Ke Zhuang , Yifei Chen , Ruiquan Ge , Changmiao Wang , Gangyong Jia , Qing Wu , Juan Ye , Maimaiti Nuliqiman , Peifang Xu , Ahmed Elazab

Inverse design in nanophotonics, the computational discovery of structures achieving targeted electromagnetic (EM) responses, has become a key tool for recent optical advances. Traditional intuition-driven or iterative optimization methods…

Applied Physics · Physics 2025-10-15 Reza Marzban , Ali Adibi , Raphael Pestourie

The electronic structure of a material fundamentally determines its underlying physical, and by extension, its functional properties. Consequently, the ability to identify or generate materials with desired electronic properties would…

Materials Science · Physics 2025-04-09 Shuyi Jia , Panchapakesan Ganesh , Victor Fung

The inverse design of microstructures plays a pivotal role in optimizing metamaterials with specific, targeted physical properties. While traditional forward design methods are constrained by their inability to explore the vast…

Computer Vision and Pattern Recognition · Computer Science 2025-02-06 Tianyang Xue , Haochen Li , Longdu Liu , Paul Henderson , Pengbin Tang , Lin Lu , Jikai Liu , Haisen Zhao , Hao Peng , Bernd Bickel

Time-varying nanostructures allow us to control the spatial and temporal properties of light. The temporal modulation of the nanostructures constitutes an additional degree of freedom to control their scattering properties on demand and in…

We present a novel learning-based method to build a differentiable computational model of a real fluorescence microscope. Our model can be used to calibrate a real optical setup directly from data samples and to engineer point spread…

Image and Video Processing · Electrical Eng. & Systems 2023-06-12 Josue Page , Paolo Favaro

The research of metamaterials has achieved enormous success in the manipulation of light in an artificially prescribed manner using delicately designed sub-wavelength structures, so-called meta-atoms. Even though modern numerical methods…

Optics · Physics 2019-01-31 Wei Ma , Feng Cheng , Yihao Xu , Qinlong Wen , Yongmin Liu

Programmable structures are systems whose undeformed geometries and material property distributions are deliberately designed to achieve prescribed deformed configurations under specific loading conditions. Inflatable structures are a…

Computational Engineering, Finance, and Science · Computer Science 2025-08-19 Sara Karimi , Nikolaos N. Vlassis

Flexible control light field across multiple parameters is the cornerstone of versatile and miniaturized optical devices. Metasurfaces, comprising subwavelength scatterers, offer a potent platform for executing such precise manipulations.…

We present a simulation capability for micro-scale light-emitting diodes (uLEDs) that achieves comparable accuracy to CPU-based finite-difference time-domain simulation but is more than 10^7 times faster. Our approach is based on the…

Computational Physics · Physics 2023-08-21 Martin F. Schubert , Alec M. Hammond

Deep learning has emerged as a key tool for designing nanophotonic structures that manipulate light at sub-wavelength scales. We investigate how to inversely design plasmonic nanostructures using conditional generative adversarial networks.…

Optics · Physics 2026-05-21 Petter Persson , Nils Henriksson , Nicolò Maccaferri

Inverse design is a central goal in much of science and engineering, including frequency-selective surfaces (FSS) that are critical to microelectronics for telecommunications and optical metamaterials. Traditional surrogate-assisted…