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Transjugular intrahepatic portosystemic shunt (TIPS) is an established procedure for portal hypertension, but provides variable survival outcomes and frequent overt hepatic encephalopathy (OHE), indicating the necessity of accurate…
Predicting the risk of clinical progression from cognitively normal (CN) status to mild cognitive impairment (MCI) or Alzheimer's disease (AD) is critical for early intervention in Alzheimer's disease (AD). Traditional survival models often…
One of the most common ways researchers compare survival outcomes across treatments when confounding is present is using Cox regression. This model is limited by its underlying assumption of proportional hazards; in some cases, substantial…
Obsessive-compulsive disorder (OCD) is a mental health condition that significantly impacts people's quality of life. While evidence-based therapies such as exposure and response prevention (ERP) can be effective, managing OCD symptoms in…
The conceptual structure of opioids, based on the bibliometric analysis of 4,935 articles of the Web of Science was constructed. The results were processed identifying the most cited articles to extract the main connections and frequencies…
Adverse Drug Reactions (ADRs) are a leading cause of morbidity and mortality. Existing prediction methods rely mainly on chemical similarity, machine learning on structured databases, or isolated target profiles, but often fail to integrate…
Survival models are a popular tool for the analysis of time to event data with applications in medicine, engineering, economics, and many more. Advances like the Cox proportional hazard model have enabled researchers to better describe…
We propose a novel optimization framework to predict clinical severity from resting state fMRI (rs-fMRI) data. Our model consists of two coupled terms. The first term decomposes the correlation matrices into a sparse set of representative…
Despite extensive safety assessments of drugs prior to their introduction to the market, certain adverse drug reactions (ADRs) remain undetected. The primary objective of pharmacovigilance is to identify these ADRs (i.e., signals). In…
Erowid.org is a website dedicated to documenting information about psychoactive substances, with over 36,000 user-submitted drug Experience Reports. We study the potential of these reports to provide information about characteristic…
We describe two recently proposed machine learning approaches for discovering emerging trends in fatal accidental drug overdoses. The Gaussian Process Subset Scan enables early detection of emerging patterns in spatio-temporal data,…
Obsessive-compulsive disorder (OCD) is a common psychiatric disorder with a lifetime prevalence of 2-3 percent. Recently, brain activity in the resting state is gathering attention as a new means of exploring altered functional connectivity…
Large-scale models require substantial computational resources for analysis and studying treatment conditions. Specifically, estimating treatment effects using simulations may require a lot of infeasible resources to allocate at every…
Sickle Cell Disease (SCD) is a chronic genetic disorder characterized by recurrent acute painful episodes. Opioids are often used to manage these painful episodes; the extent of their use in managing pain in this disorder is an issue of…
Chronic diseases are long-lasting conditions that require lifelong medical attention. Using big EMR data, we have developed early disease risk prediction models for five common chronic diseases: diabetes, hypertension, CKD, COPD, and…
Resting-state functional magnetic resonance imaging (fMRI) has emerged as a cornerstone for psychiatric diagnosis, yet most approaches rely on pairwise brain cortical or sub-cortical connectivities that overlooks higher-order interactions…
Synthetic opioids are the most common drugs involved in drug-involved overdose mortalities in the U.S. The Center for Disease Control and Prevention reported that in 2018, about 70% of all drug overdose deaths involved opioids and 67% of…
This study addresses the challenges of symptom evolution complexity and insufficient temporal dependency modeling in Parkinson's disease progression prediction. It proposes a unified prediction framework that integrates structural…
The increasing prevalence of mental health disorders, such as depression, anxiety, and bipolar disorder, calls for immediate need in developing tools for early detection and intervention. Social media platforms, like Reddit, represent a…
With the increasing legalization of medical and recreational use of cannabis, more research is needed to understand the association between depression and consumer behavior related to cannabis consumption. Big social media data has…