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Large language models (LLMs) have immense potential to make information more accessible, particularly in medicine, where complex medical jargon can hinder patient comprehension of clinical notes. We developed a patient-facing tool using…

Large language models (LLMs) have shown remarkable capabilities in various natural language tasks and are increasingly being applied in healthcare domains. This work demonstrates a new LLM-powered disease risk assessment approach via…

Computation and Language · Computer Science 2024-09-24 Mohammad Amin Roshani , Xiangyu Zhou , Yao Qiang , Srinivasan Suresh , Steve Hicks , Usha Sethuraman , Dongxiao Zhu

Genes, proteins and other biological entities influence one another via causal molecular networks. Causal relationships in such networks are mediated by complex and diverse mechanisms, through latent variables, and are often specific to…

Machine Learning · Computer Science 2025-03-07 Izzy Newsham , Luka Kovačević , Richard Moulange , Nan Rosemary Ke , Sach Mukherjee

While current large language models (LLMs) demonstrate remarkable linguistic capabilities through training on massive unstructured text corpora, they remain inadequate in leveraging structured scientific data (e.g., chemical molecular…

Machine Learning · Computer Science 2025-04-08 Weichen Dai , Zijie Dai , Zhijie Huang , Yixuan Pan , Xinhe Li , Xi Li , Yi Zhou , Ji Qi , Wu Jiang

Contemporary large language models (LLMs) may have utility for processing unstructured, narrative free-text clinical data contained in electronic health records (EHRs) -- a particularly important use-case for mental health where a majority…

Artificial Intelligence · Computer Science 2024-04-01 Niall Taylor , Andrey Kormilitzin , Isabelle Lorge , Alejo Nevado-Holgado , Dan W Joyce

This position paper examines how large language models (LLMs) can support thematic analysis of unstructured clinical transcripts, a widely used but resource-intensive method for uncovering patterns in patient and provider narratives. We…

Computation and Language · Computer Science 2025-09-30 Seungjun Yi , Joakim Nguyen , Terence Lim , Andrew Well , Joseph Skrovan , Mehak Beri , YongGeon Lee , Kavita Radhakrishnan , Liu Leqi , Mia Markey , Ying Ding

Existing depression screening predominantly relies on standardized questionnaires (e.g., PHQ-9, BDI), which suffer from high misdiagnosis rates (18-34% in clinical studies) due to their static, symptom-counting nature and susceptibility to…

Neurons and Cognition · Quantitative Biology 2025-04-24 Zhenguang Zhong , Zhixuan Wang

Background: Type 2 diabetes mellitus (T2DM) is increasingly recognised as a systemic disease characterised by coordinated dysfunction across metabolic, renal, lipid, and inflammatory pathways. Existing clinical assessments often fail to…

Machine Learning · Computer Science 2026-05-26 Mini Han Wang , Liting Huang , Wei Hong , Boonthawan Wingwon

We propose a clinical decision support system (CDSS) for mental health diagnosis that combines the strengths of large language models (LLMs) and constraint logic programming (CLP). Having a CDSS is important because of the high complexity…

Artificial Intelligence · Computer Science 2025-02-24 Brian Hyeongseok Kim , Chao Wang

Large language models (LLMs) are increasingly used to extract clinical data from electronic health records (EHRs), offering significant improvements in scalability and efficiency for real-world data (RWD) curation in oncology. However, the…

In-hospital mortality (IHM) prediction for ICU patients is critical for timely interventions and efficient resource allocation. While structured physiological data provides quantitative insights, clinical notes offer unstructured,…

Computation and Language · Computer Science 2024-11-27 Harshavardhan Battula , Jiacheng Liu , Jaideep Srivastava

Widespread stigma, both in the offline and online spaces, acts as a barrier to harm reduction efforts in the context of opioid use disorder (OUD). This stigma is prominently directed towards clinically approved medications for addiction…

Social and Information Networks · Computer Science 2025-04-16 Shravika Mittal , Darshi Shah , Shin Won Do , Mai ElSherief , Tanushree Mitra , Munmun De Choudhury

Objective: This study introduces ChatSchema, an effective method for extracting and structuring information from unstructured data in medical paper reports using a combination of Large Multimodal Models (LMMs) and Optical Character…

Computation and Language · Computer Science 2024-07-29 Fei Wang , Yuewen Zheng , Qin Li , Jingyi Wu , Pengfei Li , Luxia Zhang

Recent work shows promising results in expanding the capabilities of large language models (LLM) to directly understand and synthesize speech. However, an LLM-based strategy for modeling spoken dialogs remains elusive, calling for further…

Large-scale language models (LLMs) often offer clinical judgments based on incomplete information, increasing the risk of misdiagnosis. Existing studies have primarily evaluated confidence in single-turn, static settings, overlooking the…

Computation and Language · Computer Science 2026-01-23 Zhiyao Ren , Yibing Zhan , Siyuan Liang , Guozheng Ma , Baosheng Yu , Dacheng Tao

Structured output from large language models (LLMs) has enhanced efficiency in processing generated information and is increasingly adopted in industrial applications. Prior studies have investigated the impact of structured output on LLMs'…

Computation and Language · Computer Science 2025-12-22 Han Yuan , Yue Zhao , Li Zhang , Wuqiong Luo , Zheng Ma

This study presents a web-based interactive health risk prediction tool designed to assess diabetes risk using machine learning models. Built on the 2015 CDC BRFSS dataset, the study evaluates models including Logistic Regression, Random…

Machine Learning · Computer Science 2025-05-12 Udaya Allani

Storytelling is a powerful form of communication and may provide insights into factors contributing to gaps in healthcare outcomes. To determine whether Large Language Models (LLMs) can identify potential underlying factors and avenues for…

Computers and Society · Computer Science 2025-10-30 Maneesh Bilalpur , Megan Hamm , Young Ji Lee , Natasha Norman , Kathleen M. McTigue , Yanshan Wang

Large Language Models (LLMs) have emerged as powerful candidates to inform clinical decision-making processes. While these models play an increasingly prominent role in shaping the digital landscape, two growing concerns emerge in…

Computation and Language · Computer Science 2024-04-24 Raphael Poulain , Hamed Fayyaz , Rahmatollah Beheshti

Depression remains a pressing global mental health issue, driving considerable research into AI-driven detection approaches. While pre-trained models, particularly speech self-supervised models (SSL Models), have been applied to depression…

Audio and Speech Processing · Electrical Eng. & Systems 2025-03-11 Xiangyu Zhang , Beena Ahmed , Julien Epps