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The rapid advancement of large language models (LLMs) has accelerated their integration into clinical decision support, particularly in prescription review. To enable systematic and fine-grained evaluation, we developed RxBench, a…

Computation and Language · Computer Science 2025-12-03 Yan Yang , Mouxiao Bian , Peiling Li , Bingjian Wen , Ruiyao Chen , Kangkun Mao , Xiaojun Ye , Tianbin Li , Pengcheng Chen , Bing Han , Jie Xu , Kaifeng Qiu , Junyan Wu

Recent advances in large language models (LLMs) have stepped forward the development of multilingual speech and machine translation by its reduced representation errors and incorporated external knowledge. However, both translation tasks…

Computation and Language · Computer Science 2024-05-17 Yuchen Hu , Chen Chen , Chao-Han Huck Yang , Ruizhe Li , Dong Zhang , Zhehuai Chen , Eng Siong Chng

For Large Language Models (LLMs), a disconnect persists between benchmark performance and real-world utility. Current evaluation frameworks remain fragmented, prioritizing technical metrics while neglecting holistic assessment for…

Artificial Intelligence · Computer Science 2025-11-19 Jun Wang , Ninglun Gu , Kailai Zhang , Zijiao Zhang , Yelun Bao , Jin Yang , Xu Yin , Liwei Liu , Yihuan Liu , Pengyong Li , Gary G. Yen , Junchi Yan

Interpreting gene clusters from RNA sequencing (RNA-seq) remains challenging, especially in antimicrobial resistance studies where mechanistic insight is important for hypothesis generation. Existing pathway enrichment methods can summarize…

Quantitative Methods · Quantitative Biology 2026-04-03 Elias Hossain , Mehrdad Shoeibi , Ivan Garibay , Niloofar Yousefi

Ontology matching (OM) plays an essential role in enabling semantic interoperability and integration across heterogeneous knowledge sources, particularly in the biomedical domain which contains numerous complex concepts related to diseases…

Artificial Intelligence · Computer Science 2026-04-03 Yiping Song , Jiaoyan Chen , Renate A. Schmidt

Despite strong performance in medical question-answering, the clinical adoption of Large Language Models (LLMs) is critically hampered by their opaque 'black-box' reasoning, limiting clinician trust. This challenge is compounded by the…

Computer Vision and Pattern Recognition · Computer Science 2025-05-13 Chao Ding , Mouxiao Bian , Pengcheng Chen , Hongliang Zhang , Tianbin Li , Lihao Liu , Jiayuan Chen , Zhuoran Li , Yabei Zhong , Yongqi Liu , Haiqing Huang , Dongming Shan , Junjun He , Jie Xu

While Large Language Models (LLMs) demonstrate remarkable capabilities in scientific tasks such as literature analysis and experimental design (e.g., accurately extracting key findings from papers or generating coherent experimental…

Computation and Language · Computer Science 2026-02-24 Kai Ruan , Xuan Wang , Jixiang Hong , Peng Wang , Yang Liu , Hao Sun

Research on long non-coding RNAs (lncRNAs) has garnered significant attention due to their critical roles in gene regulation and disease mechanisms. However, the complexity and diversity of lncRNA sequences, along with the limited knowledge…

Genomics · Quantitative Biology 2024-11-07 Wei Wang , Zhichao Hou , Xiaorui Liu , Xinxia Peng

The significant advancements in visual understanding and instruction following from Multimodal Large Language Models (MLLMs) have opened up more possibilities for broader applications in diverse and universal human-centric scenarios.…

Computer Vision and Pattern Recognition · Computer Science 2024-10-10 Keliang Li , Zaifei Yang , Jiahe Zhao , Hongze Shen , Ruibing Hou , Hong Chang , Shiguang Shan , Xilin Chen

As large language models (LLMs) become increasingly integrated into clinical decision-making, ensuring transparent and trustworthy reasoning is essential. However, existing evaluation strategies of LLMs' medical reasoning capability either…

Phonology, the study of speech's structure and pronunciation rules, is a critical yet often overlooked component in Large Language Model (LLM) research. LLMs are widely used in various downstream applications that leverage phonology such as…

Computation and Language · Computer Science 2024-04-08 Ashima Suvarna , Harshita Khandelwal , Nanyun Peng

This research paper discusses the advances made in the past decade in biomedicine and Large Language Models. To understand how the advances have been made hand-in-hand with one another, the paper also discusses the integration of Natural…

Computation and Language · Computer Science 2024-06-26 Michael Ackerman

While Large Language Models have achieved remarkable integration in various vertical scenarios, their deployment in the telecommunications domain remains exploratory due to the lack of a standardized evaluation framework. Current telecom…

Artificial Intelligence · Computer Science 2026-05-19 Jieting Xiao , Yun Lin , Huizhen Qiu , Rui Ma , Chen Zhong , Dongyang Xu , Xiao Long , Chaoyu Zhang , Qiaobo Hao , Ding Zou , Zhiguo Yang , Yanqin Gao , Fang Tan

The intricate relationship between genetic variation and human diseases has been a focal point of medical research, evidenced by the identification of risk genes regarding specific diseases. The advent of advanced genome sequencing…

Quantitative Methods · Quantitative Biology 2024-01-19 Jiayu Chang , Shiyu Wang , Chen Ling , Zhaohui Qin , Liang Zhao

HealthBranches is a novel benchmark dataset for medical Question-Answering (Q&A), specifically designed to evaluate complex reasoning in Large Language Models (LLMs). This dataset is generated through a semi-automated pipeline that…

Computation and Language · Computer Science 2025-08-12 Cristian Cosentino , Annamaria Defilippo , Marco Dossena , Christopher Irwin , Sara Joubbi , Pietro Liò

Biomedical queries often rely on a deep understanding of specialized knowledge such as gene regulatory mechanisms and pathological processes of diseases. They require detailed analysis of complex physiological processes and effective…

Computation and Language · Computer Science 2026-02-02 Congying Liu , Xingyuan Wei , Peipei Liu , Yiqing Shen , Yanxu Mao , Tiehan Cui

Multimodal Large Language Models (MLLMs) have demonstrated significant potential to advance a broad range of domains. However, current benchmarks for evaluating MLLMs primarily emphasize general knowledge and vertical step-by-step reasoning…

The adoption of large language models (LLMs) to assist clinicians has attracted remarkable attention. Existing works mainly adopt the close-ended question-answering (QA) task with answer options for evaluation. However, many clinical…

Whether Large Language Models (LLMs) truly possess human-like Theory of Mind (ToM) capabilities has garnered increasing attention. However, existing benchmarks remain largely restricted to narrow paradigms like false belief tasks, failing…

Artificial Intelligence · Computer Science 2026-01-23 Haibo Tong , Zeyang Yue , Feifei Zhao , Erliang Lin , Lu Jia , Ruolin Chen , Yinqian Sun , Qian Zhang , Yi Zeng

Large language models (LLMs) have shown potential in biomedical applications, leading to efforts to fine-tune them on domain-specific data. However, the effectiveness of this approach remains unclear. This study evaluates the performance of…