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The ability of large language models (LLMs) to mimic human-like intelligence has led to a surge in LLM-based autonomous agents. Though recent LLMs seem capable of planning and reasoning given user instructions, their effectiveness in…

While large language models (LLMs) achieve near-perfect scores on medical licensing exams, these evaluations inadequately reflect the complexity and diversity of real-world clinical practice. We introduce MedHELM, an extensible evaluation…

Large language models (LLMs) have sparked growing interest in machine learning research agents that can autonomously propose ideas and conduct experiments. However, existing benchmarks predominantly adopt an engineering-oriented…

Computation and Language · Computer Science 2026-02-26 Qiran Zou , Hou Hei Lam , Wenhao Zhao , Yiming Tang , Tingting Chen , Samson Yu , Tianyi Zhang , Chang Liu , Xiangyang Ji , Dianbo Liu

Background: The rapid integration of foundation models into clinical practice and public health necessitates a rigorous evaluation of their true clinical reasoning capabilities beyond narrow examination success. Current benchmarks,…

Computer Vision and Pattern Recognition · Computer Science 2025-12-30 Dingyu Wang , Zimu Yuan , Jiajun Liu , Shanggui Liu , Nan Zhou , Tianxing Xu , Di Huang , Dong Jiang

Gene regulatory networks (GRNs) represent the causal relationships between transcription factors (TFs) and target genes in single-cell RNA sequencing (scRNA-seq) data. Understanding these networks is crucial for uncovering disease…

Artificial Intelligence · Computer Science 2024-10-22 Tejumade Afonja , Ivaxi Sheth , Ruta Binkyte , Waqar Hanif , Thomas Ulas , Matthias Becker , Mario Fritz

With the rapid development of Large Language Models (LLMs), it is crucial to have benchmarks which can evaluate the ability of LLMs on different domains. One common use of LLMs is performing tasks on scientific topics, such as writing…

Large language models (LLMs) have demonstrated remarkable progress in understanding long-context inputs. However, benchmarks for evaluating the long-context reasoning abilities of LLMs fall behind the pace. Existing benchmarks often focus…

Computation and Language · Computer Science 2025-11-19 Zhan Ling , Kang Liu , Kai Yan , Yifan Yang , Weijian Lin , Ting-Han Fan , Lingfeng Shen , Zhengyin Du , Jiecao Chen

Recent advancements in reasoning-enhanced large language models (LLMs), such as DeepSeek-R1 and OpenAI-o3, have demonstrated significant progress. However, their application in professional medical contexts remains underexplored,…

Computation and Language · Computer Science 2025-03-11 Pengcheng Qiu , Chaoyi Wu , Shuyu Liu , Weike Zhao , Zhuoxia Chen , Hongfei Gu , Chuanjin Peng , Ya Zhang , Yanfeng Wang , Weidi Xie

Recently, there has been growing interest in using Large Language Models (LLMs) for scientific research. Numerous benchmarks have been proposed to evaluate the ability of LLMs for scientific research. However, current benchmarks are mostly…

Computation and Language · Computer Science 2024-11-08 Liangtai Sun , Yang Han , Zihan Zhao , Da Ma , Zhennan Shen , Baocai Chen , Lu Chen , Kai Yu

This study evaluates large language models (LLMs) in generating code from algorithm descriptions in recent NLP papers. The task requires two key competencies: (1) algorithm comprehension: synthesizing information from papers and academic…

Computation and Language · Computer Science 2025-08-08 Yanzheng Xiang , Hanqi Yan , Shuyin Ouyang , Lin Gui , Yulan He

Evaluating the abilities of large models and manifesting their gaps are challenging. Current benchmarks adopt either ground-truth-based score-form evaluation on static datasets or indistinct textual chatbot-style human preferences…

Computer Vision and Pattern Recognition · Computer Science 2025-08-11 Zijian Chen , Lirong Deng , Zhengyu Chen , Kaiwei Zhang , Qi Jia , Yuan Tian , Yucheng Zhu , Guangtao Zhai

The parallels between protein sequences and natural language in their sequential structures have inspired the application of large language models (LLMs) to protein understanding. Despite the success of LLMs in NLP, their effectiveness in…

Quantitative Methods · Quantitative Biology 2024-07-09 Yiqing Shen , Zan Chen , Michail Mamalakis , Luhan He , Haiyang Xia , Tianbin Li , Yanzhou Su , Junjun He , Yu Guang Wang

Clinical decision-making requires reasoning over incomplete, imprecise, and linguistically expressed patient narratives. While large language models (LLMs) excel at extracting latent information from natural language, they lack the…

Artificial Intelligence · Computer Science 2026-05-26 Xiaoyang Fan , Yufan Cai , Zhe Hou , Jin Song Dong

Predictive analysis is a cornerstone of modern decision-making, with applications in various domains. Large Language Models (LLMs) have emerged as powerful tools in enabling nuanced, knowledge-intensive conversations, thus aiding in complex…

Computation and Language · Computer Science 2025-05-26 Qin Chen , Yuanyi Ren , Xiaojun Ma , Yuyang Shi

Large Language Models (LLMs) have rapidly become important tools in Biomedical and Health Informatics (BHI), enabling new ways to analyze data, treat patients, and conduct research. This study aims to provide a comprehensive overview of LLM…

Digital Libraries · Computer Science 2024-07-30 Huizi Yu , Lizhou Fan , Lingyao Li , Jiayan Zhou , Zihui Ma , Lu Xian , Wenyue Hua , Sijia He , Mingyu Jin , Yongfeng Zhang , Ashvin Gandhi , Xin Ma

The rapid evolution of large language models (LLMs) has expanded their capabilities from basic dialogue to advanced scientific reasoning. However, existing benchmarks in biology often fail to assess a critical skill required of researchers:…

Artificial Intelligence · Computer Science 2026-02-06 Junting Zhou , Jin Chen , Linfeng Hao , Denghui Cao , Zheyu Wang , Qiguang Chen , Chaoyou Fu , Jiaze Chen , Yuchen Wu , Ge Zhang , Mingxuan Wang , Wenhao Huang , Tong Yang

Based on powerful Large Language Models (LLMs), recent generative Multimodal Large Language Models (MLLMs) have gained prominence as a pivotal research area, exhibiting remarkable capability for both comprehension and generation. In this…

Computation and Language · Computer Science 2023-08-03 Bohao Li , Rui Wang , Guangzhi Wang , Yuying Ge , Yixiao Ge , Ying Shan

Recent large language models (LLMs) have advanced table understanding capabilities but rely on converting tables into text sequences. While multimodal large language models (MLLMs) enable direct visual processing, they face limitations in…

Computation and Language · Computer Science 2025-02-26 Bohao Yang , Yingji Zhang , Dong Liu , André Freitas , Chenghua Lin

Rare disease diagnosis requires matching variant-bearing genes to complex patient phenotypes across large and heterogeneous evidence sources. This process remains time-intensive in current clinical interpretation pipelines. To overcome…

Genomics · Quantitative Biology 2026-03-09 Jaeyeon Lee , Lin Yao , Hyun-Hwan Jeong , Zhandong Liu

Multimodal Large Language Models (MLLMs) have demonstrated significant advances in visual understanding tasks. However, their capacity to comprehend human-centric scenes has rarely been explored, primarily due to the absence of…

Computer Vision and Pattern Recognition · Computer Science 2025-10-16 Yuansen Liu , Haiming Tang , Jinlong Peng , Jiangning Zhang , Xiaozhong Ji , Qingdong He , Wenbin Wu , Donghao Luo , Zhenye Gan , Junwei Zhu , Yunhang Shen , Chaoyou Fu , Chengjie Wang , Xiaobin Hu , Shuicheng Yan
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