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The challenge in controlling stochastic systems in which low-probability events can set the system on catastrophic trajectories is to develop a robust ability to respond to such events without significantly compromising the optimality of…

Populations and Evolution · Quantitative Biology 2020-10-28 Dalit Engelhardt

Adaptive control in biological systems, such as intestinal immunity, remains poorly understood despite detailed knowledge of underlying regulatory networks. We propose an alternative framework based on stochastic martingale turnover, in…

Adaptation and Self-Organizing Systems · Physics 2026-05-01 Tomoyuki Yamaguchi

This paper proposes a new formulation for the dynamic resource allocation problem, which converts the traditional MDP model with known parameters and no capacity constraints to a new model with uncertain parameters and a resource capacity…

Optimization and Control · Mathematics 2020-11-10 Onur Demiray , Evrim Didem Güneş , Lerzan Örmeci

Despite major environmental and genetic differences, microbial metabolic networks are known to generate consistent physiological outcomes across vastly different organisms. This remarkable robustness suggests that, at least in bacteria,…

Molecular Networks · Quantitative Biology 2022-05-24 Anna Paola Muntoni , Alfredo Braunstein , Andrea Pagnani , Daniele De Martino , Andrea De Martino

How is the limited capacity of working memory efficiently used to support human linguistic behaviors? In this paper, we propose Strategic Resource Allocation (SRA) as an efficiency principle for memory encoding in sentence processing. The…

Computation and Language · Computer Science 2025-09-01 Weijie Xu , Richard Futrell

Intelligent techniques are urged to achieve automatic allocation of the computing resource in Open Radio Access Network (O-RAN), to save computing resource, increase utilization rate of them and decrease the delay. However, the existing…

Neural and Evolutionary Computing · Computer Science 2022-01-13 Gan Ruan , Leandro L. Minku , Zhao Xu , Xin Yao

A joint resource allocation (RA), user association (UA), and power control (PC) problem is addressed for proportional fairness maximization in a cooperative multiuser downlink small cell network with limited backhaul capacity, based on…

Networking and Internet Architecture · Computer Science 2018-08-14 Jonggyu Jang , Hyun Jong Yang , Hyekyung Jwa

The day we understand the time evolution of subcellular elements at a level of detail comparable to physical systems governed by Newton's laws of motion seems far away. Even so, quantitative approaches to cellular dynamics add to our…

In this paper, we analyze the quality of a large class of simple dynamic resource allocation (DRA) strategies which we name priority planning. Their aim is to control an undesired diffusion process by distributing resources to the…

Optimization and Control · Mathematics 2014-07-18 Kevin Scaman , Argyris Kalogeratos , Nicolas Vayatis

Current mathematical frameworks for predicting the flux state and macromolecular composition of the cell do not rely on thermodynamic constraints to determine the spontaneous direction of reactions. These predictions may be biologically…

Optimization and Control · Mathematics 2020-08-14 Amir Akbari , Bernhard O. Palsson

Existing batch size selection approaches in distributed machine learning rely on static allocation or simplistic heuristics that fail to adapt to heterogeneous, dynamic computing environments. We present DYNAMIX, a reinforcement learning…

Machine Learning · Computer Science 2025-10-10 Yuanjun Dai , Keqiang He , An Wang

This paper investigates the optimal harvesting strategy for a single species living in random environments whose growth is given by a regime-switching diffusion. Harvesting acts as a (stochastic) control on the size of the population. The…

Optimization and Control · Mathematics 2016-08-02 Qingshuo Song , Richard Stockbridge , Chao Zhu

We address the question of optimization of the microalgal biomass long term productivity in the framework of production in photobioreactors under the influence of day/night cycles. For that, we propose a simple bioreactor model accounting…

Optimization and Control · Mathematics 2012-04-16 Frédéric Grognard , Andrei R. Akhmetzhanov , Olivier Bernard

Any organism is embedded in an environment that changes over time. The timescale for and statistics of environmental change, the precision with which the organism can detect its environment, and the costs and benefits of particular protein…

Quantitative Methods · Quantitative Biology 2023-07-19 David A. Sivak , Matt Thomson

Cellular automata have been useful artificial models for exploring how relatively simple rules combined with spatial memory can give rise to complex emergent patterns. Moreover, studying the dynamics of how rules emerge under artificial…

Cellular Automata and Lattice Gases · Physics 2014-07-11 Theodore P. Pavlic , Alyssa M. Adams , Paul C. W. Davies , Sara Imari Walker

Models of transcriptional regulation that assume equilibrium binding of transcription factors have been very successful at predicting gene expression from sequence in bacteria. However, analogous equilibrium models do not perform as well in…

Molecular Networks · Quantitative Biology 2021-10-14 Benjamin Zoller , Thomas Gregor , Gašper Tkačik

Constraint-based stoichiometric models are ubiquitous in metabolic research, with Flux Balance Analysis (FBA) being the most widely used method to describe metabolic phenotypes of cells growing in steady-state. Of the many variants of…

Molecular Networks · Quantitative Biology 2018-03-15 Elad Noor

The rate-distortion (RD) theory is one of the key concepts in information theory, providing theoretical limits for compression performance and guiding the source coding design, with both theoretical and practical significance. The…

Information Theory · Computer Science 2025-07-28 Shitong Wu , Sicheng Xu , Lingyi Chen , Huihui Wu , Wenyi Zhang

We outline a modeling and optimization strategy for investigating dynamic metabolic engineering interventions. Our framework is particularly useful at the early stages of research and development, often constrained by limited knowledge and…

Systems and Control · Electrical Eng. & Systems 2024-10-17 Sebastián Espinel-Ríos , José L. Avalos

The use of learning-based methods for optimizing cellular radio access networks (RAN) has received increasing attention in recent years. This coincides with a rapid increase in the number of cell sites worldwide, driven largely by dramatic…

Machine Learning · Computer Science 2024-08-14 Jimmy Li , Igor Kozlov , Di Wu , Xue Liu , Gregory Dudek