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We present a bifidelity Karhunen-Lo\`eve expansion (KLE) surrogate model for field-valued quantities of interest (QoIs) under uncertain inputs. The approach combines the spectral efficiency of the KLE with polynomial chaos expansions (PCEs)…

Machine Learning · Statistics 2025-11-07 Aniket Jivani , Cosmin Safta , Beckett Y. Zhou , Xun Huan

This article provides a primer on the spectral representation of random fields via the Karhunen-Lo\`eve Expansion (KLE). The goal is to bridge the gap between the theoretical foundations of the KLE and its application in computational…

Numerical Analysis · Mathematics 2026-05-12 Alen Alexanderian

Deep Learning is the state-of-the-art technology for segmenting brain tumours. However, this requires a lot of high-quality data, which is difficult to obtain, especially in the medical field. Therefore, our solutions address this problem…

Image and Video Processing · Electrical Eng. & Systems 2024-07-18 André Ferreira , Naida Solak , Jianning Li , Philipp Dammann , Jens Kleesiek , Victor Alves , Jan Egger

Deep learning (DL) models for segmenting various anatomical structures have achieved great success via a static DL model that is trained in a single source domain. Yet, the static DL model is likely to perform poorly in a continually…

Computer Vision and Pattern Recognition · Computer Science 2023-06-01 Xiaofeng Liu , Helen A. Shih , Fangxu Xing , Emiliano Santarnecchi , Georges El Fakhri , Jonghye Woo

Gliomas are the most prevalent type of primary brain tumors, and their accurate segmentation from MRI is critical for diagnosis, treatment planning, and longitudinal monitoring. However, the scarcity of high-quality annotated imaging data…

This report examines numerical aspects of constructing Karhunen-Lo\`{e}ve expansions (KLEs) for second-order stochastic processes. The KLE relies on the spectral decomposition of the covariance operator via the Fredholm integral equation of…

Numerical Analysis · Mathematics 2026-03-20 Cosmin Safta , Habib N. Najm

Brain tumor classification is crucial for clinical analysis and an effective treatment plan to cure patients. Deep learning models help radiologists to accurately and efficiently analyze tumors without manual intervention. However, brain…

Image and Video Processing · Electrical Eng. & Systems 2022-12-13 Mirza Mumtaz Zahoor , Saddam Hussain Khan

Another year of the multimodal brain tumor segmentation challenge (BraTS) 2021 provides an even larger dataset to facilitate collaboration and research of brain tumor segmentation methods, which are necessary for disease analysis and…

Image and Video Processing · Electrical Eng. & Systems 2021-11-02 Md Mahfuzur Rahman Siddiquee , Andriy Myronenko

A glioma is a malignant brain tumor that seriously affects cognitive functions and lowers patients' life quality. Segmentation of brain glioma is challenging because of interclass ambiguities in tumor regions. Recently, deep learning…

Image and Video Processing · Electrical Eng. & Systems 2022-11-02 Yiming Yao , Peisheng Qian , Ziyuan Zhao , Zeng Zeng

We present an Expectation-Maximization (EM) Regularized Deep Learning (EMReDL) model for weakly supervised tumor segmentation. The proposed framework is tailored to glioblastoma, a type of malignant tumor characterized by its diffuse…

Image and Video Processing · Electrical Eng. & Systems 2021-07-16 Chao Li , Wenjian Huang , Xi Chen , Yiran Wei , Stephen J. Price , Carola-Bibiane Schönlieb

Gliomas, a common type of malignant brain tumor, present significant surgical challenges due to their similarity to healthy tissue. Preoperative Magnetic Resonance Imaging (MRI) images are often ineffective during surgery due to factors…

Image and Video Processing · Electrical Eng. & Systems 2024-08-28 Samir Kassam , Angelo Markham , Katie Vo , Yashas Revanakara , Michael Lam , Kevin Zhu

Automatic segmentation is essential for the brain tumor diagnosis, disease prognosis, and follow-up therapy of patients with gliomas. Still, accurate detection of gliomas and their sub-regions in multimodal MRI is very challenging due to…

Image and Video Processing · Electrical Eng. & Systems 2022-12-20 Ramy A. Zeineldin , Mohamed E. Karar , Oliver Burgert , Franziska Mathis-Ullrich

A brain tumor, whether benign or malignant, can potentially be life threatening and requires painstaking efforts in order to identify the type, origin and location, let alone cure one. Manual segmentation by medical specialists can be…

Image and Video Processing · Electrical Eng. & Systems 2023-05-02 Ayan Gupta , Mayank Dixit , Vipul Kumar Mishra , Attulya Singh , Atul Dayal

Brain tumor classification using MRI images is critical in medical diagnostics, where early and accurate detection significantly impacts patient outcomes. While recent advancements in deep learning (DL), particularly CNNs, have shown…

Image and Video Processing · Electrical Eng. & Systems 2025-03-03 Priyam Ganguly , Akhilbaran Ghosh

Accurate segmentation of brain tumors plays a key role in the diagnosis and treatment of brain tumor diseases. It serves as a critical technology for quantifying tumors and extracting their features. With the increasing application of deep…

Image and Video Processing · Electrical Eng. & Systems 2024-11-05 Longfeng Shen , Yanqi Hou , Jiacong Chen , Liangjin Diao , Yaxi Duan

Gliomas are the most common primary brain malignancies, with different degrees of aggressiveness, variable prognosis and various heterogeneous histologic sub-regions, i.e., peritumoral edematous/invaded tissue, necrotic core, active and…

Computer Vision and Pattern Recognition · Computer Science 2019-04-24 Spyridon Bakas , Mauricio Reyes , Andras Jakab , Stefan Bauer , Markus Rempfler , Alessandro Crimi , Russell Takeshi Shinohara , Christoph Berger , Sung Min Ha , Martin Rozycki , Marcel Prastawa , Esther Alberts , Jana Lipkova , John Freymann , Justin Kirby , Michel Bilello , Hassan Fathallah-Shaykh , Roland Wiest , Jan Kirschke , Benedikt Wiestler , Rivka Colen , Aikaterini Kotrotsou , Pamela Lamontagne , Daniel Marcus , Mikhail Milchenko , Arash Nazeri , Marc-Andre Weber , Abhishek Mahajan , Ujjwal Baid , Elizabeth Gerstner , Dongjin Kwon , Gagan Acharya , Manu Agarwal , Mahbubul Alam , Alberto Albiol , Antonio Albiol , Francisco J. Albiol , Varghese Alex , Nigel Allinson , Pedro H. A. Amorim , Abhijit Amrutkar , Ganesh Anand , Simon Andermatt , Tal Arbel , Pablo Arbelaez , Aaron Avery , Muneeza Azmat , Pranjal B. , W Bai , Subhashis Banerjee , Bill Barth , Thomas Batchelder , Kayhan Batmanghelich , Enzo Battistella , Andrew Beers , Mikhail Belyaev , Martin Bendszus , Eze Benson , Jose Bernal , Halandur Nagaraja Bharath , George Biros , Sotirios Bisdas , James Brown , Mariano Cabezas , Shilei Cao , Jorge M. Cardoso , Eric N Carver , Adrià Casamitjana , Laura Silvana Castillo , Marcel Catà , Philippe Cattin , Albert Cerigues , Vinicius S. Chagas , Siddhartha Chandra , Yi-Ju Chang , Shiyu Chang , Ken Chang , Joseph Chazalon , Shengcong Chen , Wei Chen , Jefferson W Chen , Zhaolin Chen , Kun Cheng , Ahana Roy Choudhury , Roger Chylla , Albert Clérigues , Steven Colleman , Ramiro German Rodriguez Colmeiro , Marc Combalia , Anthony Costa , Xiaomeng Cui , Zhenzhen Dai , Lutao Dai , Laura Alexandra Daza , Eric Deutsch , Changxing Ding , Chao Dong , Shidu Dong , Wojciech Dudzik , Zach Eaton-Rosen , Gary Egan , Guilherme Escudero , Théo Estienne , Richard Everson , Jonathan Fabrizio , Yong Fan , Longwei Fang , Xue Feng , Enzo Ferrante , Lucas Fidon , Martin Fischer , Andrew P. French , Naomi Fridman , Huan Fu , David Fuentes , Yaozong Gao , Evan Gates , David Gering , Amir Gholami , Willi Gierke , Ben Glocker , Mingming Gong , Sandra González-Villá , T. Grosges , Yuanfang Guan , Sheng Guo , Sudeep Gupta , Woo-Sup Han , Il Song Han , Konstantin Harmuth , Huiguang He , Aura Hernández-Sabaté , Evelyn Herrmann , Naveen Himthani , Winston Hsu , Cheyu Hsu , Xiaojun Hu , Xiaobin Hu , Yan Hu , Yifan Hu , Rui Hua , Teng-Yi Huang , Weilin Huang , Sabine Van Huffel , Quan Huo , Vivek HV , Khan M. Iftekharuddin , Fabian Isensee , Mobarakol Islam , Aaron S. Jackson , Sachin R. Jambawalikar , Andrew Jesson , Weijian Jian , Peter Jin , V Jeya Maria Jose , Alain Jungo , B Kainz , Konstantinos Kamnitsas , Po-Yu Kao , Ayush Karnawat , Thomas Kellermeier , Adel Kermi , Kurt Keutzer , Mohamed Tarek Khadir , Mahendra Khened , Philipp Kickingereder , Geena Kim , Nik King , Haley Knapp , Urspeter Knecht , Lisa Kohli , Deren Kong , Xiangmao Kong , Simon Koppers , Avinash Kori , Ganapathy Krishnamurthi , Egor Krivov , Piyush Kumar , Kaisar Kushibar , Dmitrii Lachinov , Tryphon Lambrou , Joon Lee , Chengen Lee , Yuehchou Lee , M Lee , Szidonia Lefkovits , Laszlo Lefkovits , James Levitt , Tengfei Li , Hongwei Li , Wenqi Li , Hongyang Li , Xiaochuan Li , Yuexiang Li , Heng Li , Zhenye Li , Xiaoyu Li , Zeju Li , XiaoGang Li , Wenqi Li , Zheng-Shen Lin , Fengming Lin , Pietro Lio , Chang Liu , Boqiang Liu , Xiang Liu , Mingyuan Liu , Ju Liu , Luyan Liu , Xavier Llado , Marc Moreno Lopez , Pablo Ribalta Lorenzo , Zhentai Lu , Lin Luo , Zhigang Luo , Jun Ma , Kai Ma , Thomas Mackie , Anant Madabushi , Issam Mahmoudi , Klaus H. Maier-Hein , Pradipta Maji , CP Mammen , Andreas Mang , B. S. Manjunath , Michal Marcinkiewicz , S McDonagh , Stephen McKenna , Richard McKinley , Miriam Mehl , Sachin Mehta , Raghav Mehta , Raphael Meier , Christoph Meinel , Dorit Merhof , Craig Meyer , Robert Miller , Sushmita Mitra , Aliasgar Moiyadi , David Molina-Garcia , Miguel A. B. Monteiro , Grzegorz Mrukwa , Andriy Myronenko , Jakub Nalepa , Thuyen Ngo , Dong Nie , Holly Ning , Chen Niu , Nicholas K Nuechterlein , Eric Oermann , Arlindo Oliveira , Diego D. C. Oliveira , Arnau Oliver , Alexander F. I. Osman , Yu-Nian Ou , Sebastien Ourselin , Nikos Paragios , Moo Sung Park , Brad Paschke , J. Gregory Pauloski , Kamlesh Pawar , Nick Pawlowski , Linmin Pei , Suting Peng , Silvio M. Pereira , Julian Perez-Beteta , Victor M. Perez-Garcia , Simon Pezold , Bao Pham , Ashish Phophalia , Gemma Piella , G. N. Pillai , Marie Piraud , Maxim Pisov , Anmol Popli , Michael P. Pound , Reza Pourreza , Prateek Prasanna , Vesna Prkovska , Tony P. Pridmore , Santi Puch , Élodie Puybareau , Buyue Qian , Xu Qiao , Martin Rajchl , Swapnil Rane , Michael Rebsamen , Hongliang Ren , Xuhua Ren , Karthik Revanuru , Mina Rezaei , Oliver Rippel , Luis Carlos Rivera , Charlotte Robert , Bruce Rosen , Daniel Rueckert , Mohammed Safwan , Mostafa Salem , Joaquim Salvi , Irina Sanchez , Irina Sánchez , Heitor M. Santos , Emmett Sartor , Dawid Schellingerhout , Klaudius Scheufele , Matthew R. Scott , Artur A. Scussel , Sara Sedlar , Juan Pablo Serrano-Rubio , N. Jon Shah , Nameetha Shah , Mazhar Shaikh , B. Uma Shankar , Zeina Shboul , Haipeng Shen , Dinggang Shen , Linlin Shen , Haocheng Shen , Varun Shenoy , Feng Shi , Hyung Eun Shin , Hai Shu , Diana Sima , M Sinclair , Orjan Smedby , James M. Snyder , Mohammadreza Soltaninejad , Guidong Song , Mehul Soni , Jean Stawiaski , Shashank Subramanian , Li Sun , Roger Sun , Jiawei Sun , Kay Sun , Yu Sun , Guoxia Sun , Shuang Sun , Yannick R Suter , Laszlo Szilagyi , Sanjay Talbar , Dacheng Tao , Dacheng Tao , Zhongzhao Teng , Siddhesh Thakur , Meenakshi H Thakur , Sameer Tharakan , Pallavi Tiwari , Guillaume Tochon , Tuan Tran , Yuhsiang M. Tsai , Kuan-Lun Tseng , Tran Anh Tuan , Vadim Turlapov , Nicholas Tustison , Maria Vakalopoulou , Sergi Valverde , Rami Vanguri , Evgeny Vasiliev , Jonathan Ventura , Luis Vera , Tom Vercauteren , C. A. Verrastro , Lasitha Vidyaratne , Veronica Vilaplana , Ajeet Vivekanandan , Guotai Wang , Qian Wang , Chiatse J. Wang , Weichung Wang , Duo Wang , Ruixuan Wang , Yuanyuan Wang , Chunliang Wang , Guotai Wang , Ning Wen , Xin Wen , Leon Weninger , Wolfgang Wick , Shaocheng Wu , Qiang Wu , Yihong Wu , Yong Xia , Yanwu Xu , Xiaowen Xu , Peiyuan Xu , Tsai-Ling Yang , Xiaoping Yang , Hao-Yu Yang , Junlin Yang , Haojin Yang , Guang Yang , Hongdou Yao , Xujiong Ye , Changchang Yin , Brett Young-Moxon , Jinhua Yu , Xiangyu Yue , Songtao Zhang , Angela Zhang , Kun Zhang , Xuejie Zhang , Lichi Zhang , Xiaoyue Zhang , Yazhuo Zhang , Lei Zhang , Jianguo Zhang , Xiang Zhang , Tianhao Zhang , Sicheng Zhao , Yu Zhao , Xiaomei Zhao , Liang Zhao , Yefeng Zheng , Liming Zhong , Chenhong Zhou , Xiaobing Zhou , Fan Zhou , Hongtu Zhu , Jin Zhu , Ying Zhuge , Weiwei Zong , Jayashree Kalpathy-Cramer , Keyvan Farahani , Christos Davatzikos , Koen van Leemput , Bjoern Menze

Deep learning has quickly become the weapon of choice for brain lesion segmentation. However, few existing algorithms pre-configure any biological context of their chosen segmentation tissues, and instead rely on the neural network's…

Computer Vision and Pattern Recognition · Computer Science 2017-09-12 Andrew Beers , Ken Chang , James Brown , Emmett Sartor , CP Mammen , Elizabeth Gerstner , Bruce Rosen , Jayashree Kalpathy-Cramer

State-of-the-art brain tumor segmentation is based on deep learning models applied to multi-modal MRIs. Currently, these models are trained on images after a preprocessing stage that involves registration, interpolation, brain extraction…

Image and Video Processing · Electrical Eng. & Systems 2022-12-29 Bruno Machado Pacheco , Guilherme de Souza e Cassia , Danilo Silva

Karhunen-Loeve expansions (KLE) of stochastic processes are important tools in mathematics, the sciences, economics, and engineering. However, the KLE is primarily useful for those processes for which we can identify the necessary…

Probability · Mathematics 2016-03-03 Daniel Hackmann

This study systematically investigates the impact of image enhancement techniques on Convolutional Neural Network (CNN)-based Brain Tumor Segmentation, focusing on Histogram Equalization (HE), Contrast Limited Adaptive Histogram…

Image and Video Processing · Electrical Eng. & Systems 2024-04-09 Shoffan Saifullah , Andri Pranolo , Rafał Dreżewski
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