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The correlation of optical measurements with a correct pathology label is often hampered by imprecise registration caused by deformations in histology images. This study explores an automated multi-modal image registration technique…

Image and Video Processing · Electrical Eng. & Systems 2023-11-27 Lianne Feenstra , Maud Lambregts , Theo J. M Ruers , Behdad Dashtbozorg

We present deformable unsupervised medical image registration using a randomly-initialized deep convolutional neural network (CNN) as regularization prior. Conventional registration methods predict a transformation by minimizing…

Image and Video Processing · Electrical Eng. & Systems 2019-08-05 Max-Heinrich Laves , Sontje Ihler , Tobias Ortmaier

Image registration is the process of bringing different images into a common coordinate system - a technique widely used in various applications of computer vision, such as remote sensing, image retrieval, and, most commonly, medical…

In clinical practice, imaging modalities with functional characteristics, such as positron emission tomography (PET) and fractional anisotropy (FA), are often aligned with a structural reference (e.g., MRI, CT) for accurate interpretation…

Computer Vision and Pattern Recognition · Computer Science 2025-07-01 Kyobin Choo , Hyunkyung Han , Jinyeong Kim , Chanyong Yoon , Seong Jae Hwang

Deformable registration has been one of the pillars of biomedical image computing. Conventional approaches refer to the definition of a similarity criterion that, once endowed with a deformation model and a smoothness constraint, determines…

Computer Vision and Pattern Recognition · Computer Science 2018-09-25 Enzo Ferrante , Puneet K. Dokania , Rafael Marini Silva , Nikos Paragios

In this paper, we propose SRIF, a novel Semantic shape Registration framework based on diffusion-based Image morphing and Flow estimation. More concretely, given a pair of extrinsically aligned shapes, we first render them from multi-views,…

Computer Vision and Pattern Recognition · Computer Science 2024-10-04 Mingze Sun , Chen Guo , Puhua Jiang , Shiwei Mao , Yurun Chen , Ruqi Huang

Misalignments between multi-modality images pose challenges in image fusion, manifesting as structural distortions and edge ghosts. Existing efforts commonly resort to registering first and fusing later, typically employing two cascaded…

Computer Vision and Pattern Recognition · Computer Science 2023-08-23 Di Wang , Jinyuan Liu , Long Ma , Risheng Liu , Xin Fan

Diffusion MRI is a non-invasive, in-vivo biomedical imaging method for mapping tissue microstructure. Applications include structural connectivity imaging of the human brain and detecting microstructural neural changes. However, acquiring…

Image and Video Processing · Electrical Eng. & Systems 2023-10-09 Amir Sadikov , Xinlei Pan , Hannah Choi , Lanya T. Cai , Pratik Mukherjee

In ophthalmological imaging, multiple imaging systems, such as color fundus, infrared, fluorescein angiography, optical coherence tomography (OCT) or OCT angiography, are often involved to make a diagnosis of retinal disease. Multi-modal…

Computer Vision and Pattern Recognition · Computer Science 2022-07-22 Aline Sindel , Bettina Hohberger , Andreas Maier , Vincent Christlein

Magnetic Resonance Imaging (MRI), including diffusion MRI (dMRI), serves as a ``microscope'' for anatomical structures and routinely mitigates the influence of low signal-to-noise ratio scans by compromising temporal or spatial resolution.…

Image and Video Processing · Electrical Eng. & Systems 2025-03-11 Chenxu Wu , Qingpeng Kong , Zihang Jiang , S. Kevin Zhou

Recently, deep-learning-based approaches have been widely studied for deformable image registration task. However, most efforts directly map the composite image representation to spatial transformation through the convolutional neural…

Image and Video Processing · Electrical Eng. & Systems 2022-07-08 Jiashun Chen , Donghuan Lu , Yu Zhang , Dong Wei , Munan Ning , Xinyu Shi , Zhe Xu , Yefeng Zheng

Deformable registration is a fundamental task in medical image processing, aiming to achieve precise alignment by establishing nonlinear correspondences between images. Traditional methods offer good adaptability and interpretability but…

Computer Vision and Pattern Recognition · Computer Science 2025-05-13 Jing Hu , Kaiwei Yu , Hongjiang Xian , Shu Hu , Xin Wang

This article adapts the framework of metamorphosis to solve inverse problems in imaging that includes joint reconstruction and image registration. The deformations in question have two components, one that is a geometric deformation moving…

Computer Vision and Pattern Recognition · Computer Science 2018-06-25 Gris Barbara , Chen Chong , Öktem Ozan

Multimodal medical image fusion plays an instrumental role in several areas of medical image processing, particularly in disease recognition and tumor detection. Traditional fusion methods tend to process each modality independently before…

Image and Video Processing · Electrical Eng. & Systems 2023-10-11 Lin Liu , Xinxin Fan , Chulong Zhang , Jingjing Dai , Yaoqin Xie , Xiaokun Liang

Accurate image registration is essential in many medical imaging applications, yet most deep registration networks provide little indication of when or where their predictions are unreliable. Existing uncertainty estimation approaches, such…

Computer Vision and Pattern Recognition · Computer Science 2026-02-03 Lin Tian , Xiaoling Hu , Juan Eugenio Iglesias

MRI provides superior soft tissue contrast without ionizing radiation; however, the absence of electron density information limits its direct use for dose calculation. As a result, current radiotherapy workflows rely on combined MRI and CT…

Computer Vision and Pattern Recognition · Computer Science 2026-02-06 Zolnamar Dorjsembe , Hung-Yi Chen , Furen Xiao , Hsing-Kuo Pao

Data from a multi-parametric MRI study of patients with possible early-stage prostate cancer was assessed with a view to creating an efficient clinical protocol. Based on a correlation analysis suggesting that diffusion-weighted imaging…

Medical Physics · Physics 2017-11-28 Ioannis Papadopoulos , Jonathan Phillips , Rhodri Evans , Neil Fenn , Sophie Schermer

Diffusion magnetic resonance imaging (MRI) is the only imaging modality for non-invasive movement detection of in vivo water molecules, with significant clinical and research applications. Diffusion weighted imaging (DWI) MRI acquired by…

Spatial registration across different visual modalities is a critical but formidable step in multi-modality image fusion for real-world perception. Although several methods are proposed to address this issue, the existing registration-based…

Computer Vision and Pattern Recognition · Computer Science 2026-03-10 Congcong Bian , Haolong Ma , Hui Li , Zhongwei Shen , Xiaoqing Luo , Xiaoning Song , Xiao-Jun Wu

Multiparametric mapping MRI has become a viable tool for myocardial tissue characterization. However, misalignment between multiparametric maps makes pixel-wise analysis challenging. To address this challenge, we developed a generalizable…

Image and Video Processing · Electrical Eng. & Systems 2025-10-31 Xinqi Li , Yi Zhang , Li-Ting Huang , Hsiao-Huang Chang , Thoralf Niendorf , Min-Chi Ku , Qian Tao , Hsin-Jung Yang