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Retrieval-augmented generation (RAG) has rapidly emerged as a transformative approach for integrating large language models into clinical and biomedical workflows. However, privacy risks, such as protected health information (PHI) exposure,…

Cryptography and Security · Computer Science 2025-11-18 Shaowei Guan , Hin Chi Kwok , Ngai Fong Law , Gregor Stiglic , Harry Qin , Vivian Hui

Retrieval-Augmented Generation (RAG) lifts the factuality of Large Language Models (LLMs) by injecting external knowledge, yet it falls short on problems that demand multi-step inference; conversely, purely reasoning-oriented approaches…

Retrieval-Augmented Generation (RAG) systems enhance Large Language Models (LLMs) by retrieving relevant documents from external corpora before generating responses. This approach significantly expands LLM capabilities by leveraging vast,…

Cryptography and Security · Computer Science 2025-11-13 Haowei Wang , Rupeng Zhang , Junjie Wang , Mingyang Li , Yuekai Huang , Dandan Wang , Qing Wang

Large Language Models (LLMs) have demonstrated remarkable performance across a wide range of applications. However, their practical deployment is often hindered by issues such as outdated knowledge and the tendency to generate…

Cryptography and Security · Computer Science 2026-03-27 Haozhen Wang , Haoyue Liu , Jionghao Zhu , Zhichao Wang , Yongxin Guo , Xiaoying Tang

Large Language Models (LLMs) have advanced artificial intelligence by enabling human-like text generation and natural language understanding. However, their reliance on static training data limits their ability to respond to dynamic,…

Artificial Intelligence · Computer Science 2026-04-02 Aditi Singh , Abul Ehtesham , Saket Kumar , Tala Talaei Khoei , Athanasios V. Vasilakos

Retrieval-augmented generation (RAG) enhances the outputs of language models by integrating relevant information retrieved from external knowledge sources. However, when the retrieval process involves private data, RAG systems may face…

Cryptography and Security · Computer Science 2025-02-21 Shenglai Zeng , Jiankun Zhang , Pengfei He , Jie Ren , Tianqi Zheng , Hanqing Lu , Han Xu , Hui Liu , Yue Xing , Jiliang Tang

Retrieval-augmented generation (RAG) has emerged as a paradigm for grounding large language models in external knowledge, yet most existing RAG systems assume centralized knowledge access and ample computation. These assumptions break down…

Information Retrieval · Computer Science 2026-05-28 Tianhao Gao , Kai Yang , Yiyang Li

Retrieval-Augmented Generation (RAG) is a state-of-the-art technique that mitigates issues such as hallucinations and knowledge staleness in Large Language Models (LLMs) by retrieving relevant knowledge from an external database to assist…

Cryptography and Security · Computer Science 2024-09-27 Yuying Li , Gaoyang Liu , Chen Wang , Yang Yang

Large Language Models (LLMs) have greatly contributed to the development of adaptive intelligent agents and are positioned as an important way to achieve Artificial General Intelligence (AGI). However, LLMs are prone to produce factually…

Computation and Language · Computer Science 2024-08-29 Weijian Xie , Xuefeng Liang , Yuhui Liu , Kaihua Ni , Hong Cheng , Zetian Hu

Multimodal Retrieval-Augmented Generation (MRAG) systems enhance LMMs by integrating external multimodal databases, but introduce unexplored privacy vulnerabilities. While text-based RAG privacy risks have been studied, multimodal data…

Cryptography and Security · Computer Science 2025-05-21 Jiankun Zhang , Shenglai Zeng , Jie Ren , Tianqi Zheng , Hui Liu , Xianfeng Tang , Hui Liu , Yi Chang

Retrieval-Augmented Generation (RAG) systems enhance response credibility and traceability by displaying reference contexts, but this transparency simultaneously introduces a novel black-box attack vector. Existing document poisoning…

Computation and Language · Computer Science 2026-01-27 Runqi Sui

Recently, Retrieval-Augmented Generation (RAG) has achieved remarkable success in addressing the challenges of Large Language Models (LLMs) without necessitating retraining. By referencing an external knowledge base, RAG refines LLM…

Artificial Intelligence · Computer Science 2024-09-11 Boci Peng , Yun Zhu , Yongchao Liu , Xiaohe Bo , Haizhou Shi , Chuntao Hong , Yan Zhang , Siliang Tang

Retrieval-Augmented Generation (RAG) enables Large Language Models (LLMs) to generate grounded responses by leveraging external knowledge databases without altering model parameters. Although the absence of weight tuning prevents leakage…

Cryptography and Security · Computer Science 2025-07-01 Ali Naseh , Yuefeng Peng , Anshuman Suri , Harsh Chaudhari , Alina Oprea , Amir Houmansadr

Large Language Models (LLMs) remain vulnerable to jailbreak attacks, which attempt to elicit harmful responses from LLMs. The evolving nature and diversity of these attacks pose many challenges for defense systems, including (1) adaptation…

Cryptography and Security · Computer Science 2025-11-04 Guangyu Yang , Jinghong Chen , Jingbiao Mei , Weizhe Lin , Bill Byrne

Recent advancements in large language models (LLMs) and multi-modal LLMs have been remarkable. However, these models still rely solely on their parametric knowledge, which limits their ability to generate up-to-date information and…

Artificial Intelligence · Computer Science 2025-04-22 Zihan Ling , Zhiyao Guo , Yixuan Huang , Yi An , Shuai Xiao , Jinsong Lan , Xiaoyong Zhu , Bo Zheng

Large language models (LLMs) in biomedicine face a fundamental conflict between static parameter knowledge and the dynamic nature of clinical evidence. Retrieval-Augmented Generation (RAG) addresses this by grounding generation in external…

Other Quantitative Biology · Quantitative Biology 2025-12-19 Jiawei He , Boya Zhang , Hossein Rouhizadeh , Yingjian Chen , Rui Yang , Jin Lu , Xudong Chen , Nan Liu , Douglas Teodoro

Despite the impressive capabilities of large language models (LLMs) across diverse applications, they still suffer from trustworthiness issues, such as hallucinations and misalignments. Retrieval-augmented language models (RAG) have been…

Artificial Intelligence · Computer Science 2024-07-31 Mintong Kang , Nezihe Merve Gürel , Ning Yu , Dawn Song , Bo Li

Retrieval-Augmented Generation (RAG) has recently emerged as a method to extend beyond the pre-trained knowledge of Large Language Models by augmenting the original prompt with relevant passages or documents retrieved by an Information…

Large Language Models (LLMs) have shown remarkable capabilities across diverse tasks, yet they face inherent limitations such as constrained parametric knowledge and high retraining costs. Retrieval-Augmented Generation (RAG) augments the…

Information Retrieval · Computer Science 2025-08-26 Leqian Li , Dianxi Shi , Jialu Zhou , Xinyu Wei , Mingyue Yang , Songchang Jin , Shaowu Yang

Large language models (LLMs) have achieved strong empirical performance in various fields, benefiting from their huge amount of parameters that store knowledge. However, LLMs still suffer from several key issues, such as hallucination…

Computation and Language · Computer Science 2026-05-20 Shangyu Wu , Ying Xiong , Yufei Cui , Haolun Wu , Can Chen , Ye Yuan , Lianming Huang , Xue Liu , Tei-Wei Kuo , Nan Guan , Chun Jason Xue
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