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An electrocardiogram (EKG) is a common, non-invasive test that measures the electrical activity of a patient's heart. EKGs contain useful diagnostic information about patient health that may be absent from other electronic health record…

Machine Learning · Statistics 2018-12-04 Andrew C. Miller , Ziad Obermeyer , David M. Blei , John P. Cunningham , Sendhil Mullainathan

Background:The electrocardiogram (ECG) is one of the most commonly used diagnostic tools in medicine and healthcare. Deep learning methods have achieved promising results on predictive healthcare tasks using ECG signals. Objective:This…

Signal Processing · Electrical Eng. & Systems 2020-05-04 Shenda Hong , Yuxi Zhou , Junyuan Shang , Cao Xiao , Jimeng Sun

Electrocardiography (ECG) is a non-invasive tool for predicting cardiovascular diseases (CVDs). Current ECG-based diagnosis systems show promising performance owing to the rapid development of deep learning techniques. However, the label…

Signal Processing · Electrical Eng. & Systems 2023-06-21 Rushuang Zhou , Lei Lu , Zijun Liu , Ting Xiang , Zhen Liang , David A. Clifton , Yining Dong , Yuan-Ting Zhang

Heart failure (HF) affects 11.8% of adults aged 65 and older, reducing quality of life and longevity. Preventing HF can reduce morbidity and mortality. We hypothesized that artificial intelligence (AI) applied to 24-hour single-lead…

Signal Processing · Electrical Eng. & Systems 2026-01-05 Eran Zvuloni , Ronit Almog , Michael Glikson , Shany Brimer Biton , Ilan Green , Izhar Laufer , Offer Amir , Joachim A. Behar

The electrocardiogram (ECG) is an essential tool for diagnosing heart disease, with computer-aided systems improving diagnostic accuracy and reducing healthcare costs. Despite advancements, existing systems often miss rare cardiac anomalies…

Computer Vision and Pattern Recognition · Computer Science 2024-04-09 Aofan Jiang , Chaoqin Huang , Qing Cao , Yuchen Xu , Zi Zeng , Kang Chen , Ya Zhang , Yanfeng Wang

The electrocardiogram (ECG) is a key diagnostic tool in cardiovascular health. Single-lead ECG recording is integrated into both clinical-grade and consumer wearables. While self-supervised pretraining of foundation models on unlabeled ECGs…

Machine Learning · Computer Science 2025-12-03 Yuxuan Shu , Peter H. Charlton , Fahim Kawsar , Jussi Hernesniemi , Mohammad Malekzadeh

Electrocardiography (ECG) signal is a highly applied measurement for individual heart condition, and much effort have been endeavored towards automatic heart arrhythmia diagnosis based on machine learning. However, traditional machine…

Signal Processing · Electrical Eng. & Systems 2021-11-01 Ziyu Liu , Xiang Zhang

The classification of electrocardiogram (ECG) signals is crucial for early detection of arrhythmias and other cardiac conditions. However, despite advances in machine learning, many studies fail to follow standardization protocols, leading…

Computer Vision and Pattern Recognition · Computer Science 2025-03-11 Guilherme Silva , Pedro Silva , Gladston Moreira , Vander Freitas , Jadson Gertrudes , Eduardo Luz

We introduce a unified benchmarking framework focused on evaluating EEG-based foundation models in clinical applications. The benchmark spans 11 well-defined diagnostic tasks across 14 publicly available EEG datasets, including epilepsy,…

Machine Learning · Computer Science 2025-12-11 Ard Kastrati , Josua Bürki , Jonas Lauer , Cheng Xuan , Raffaele Iaquinto , Roger Wattenhofer

Laboratory value represents a cornerstone of medical diagnostics, but suffers from slow turnaround times, and high costs and only provides information about a single point in time. The continuous estimation of laboratory values from…

Signal Processing · Electrical Eng. & Systems 2025-11-21 Juan Miguel Lopez Alcaraz , Nils Strodthoff

Diagnosing pre-existing heart diseases early in life is important as it helps prevent complications such as pulmonary hypertension, heart rhythm problems, blood clots, heart failure and sudden cardiac arrest. To identify such diseases,…

Mechanistic cardiac electrophysiology models allow for personalized simulations of the electrical activity in the heart and the ensuing electrocardiogram (ECG) on the body surface. As such, synthetic signals possess known ground truth…

Electrocardiogram (ECG) is a widely used non-invasive diagnostic tool for heart diseases. Many studies have devised ECG analysis models (e.g., classifiers) to assist diagnosis. As an upstream task, researches have built generative models to…

Machine Learning · Computer Science 2023-05-30 Jintai Chen , Kuanlun Liao , Kun Wei , Haochao Ying , Danny Z. Chen , Jian Wu

Electrocardiography (ECG) analysis is crucial for cardiac diagnosis, yet existing foundation models often fail to capture the periodicity and diverse features required for varied clinical tasks. We propose ECG-MoE, a hybrid architecture…

Artificial Intelligence · Computer Science 2026-03-06 Yuhao Xu , Xiaoda Wang , Yi Wu , Wei Jin , Xiao Hu , Carl Yang

Current computer-aided ECG diagnostic systems struggle with the underdetection of rare but critical cardiac anomalies due to the imbalanced nature of ECG datasets. This study introduces a novel approach using self-supervised anomaly…

Computer Vision and Pattern Recognition · Computer Science 2024-09-02 Aofan Jiang , Chaoqin Huang , Qing Cao , Yuchen Xu , Zi Zeng , Kang Chen , Ya Zhang , Yanfeng Wang

Pandemic outbreaks such as COVID-19 occur unexpectedly, and need immediate action due to their potential devastating consequences on global health. Point-of-care routine assessments such as electrocardiogram (ECG), can be used to develop…

Signal Processing · Electrical Eng. & Systems 2023-01-12 Weijie Sun , Sunil Vasu Kalmady , Nariman Sepehrvand , Luan Manh Chu , Zihan Wang , Amir Salimi , Abram Hindle , Russell Greiner , Padma Kaul

Cardiac amyloidosis, a rare and highly morbid condition, presents significant challenges for detection through echocardiography. Recently, there has been a surge in proposing machine-learning algorithms to identify cardiac amyloidosis, with…

Image and Video Processing · Electrical Eng. & Systems 2024-06-10 Zishun Feng , Joseph A. Sivak , Ashok K. Krishnamurthy

The 12-lead electrocardiogram (ECG) is a commonly used tool for detecting cardiac abnormalities such as atrial fibrillation, blocks, and irregular complexes. For the PhysioNet/CinC 2020 Challenge, we built an algorithm using gradient…

Signal Processing · Electrical Eng. & Systems 2020-10-27 Alexander William Wong , Weijie Sun , Sunil Vasu Kalmady , Padma Kaul , Abram Hindle

Electrocardiograms (ECGs) are inexpensive, widely used, and well-suited to deep learning. Recently, interest has grown in developing foundation models for ECGs - models that generalise across diverse downstream tasks. However, consistent…

This paper introduces an innovative Electronic Health Record (EHR) foundation model that integrates Polygenic Risk Scores (PRS) as a foundational data modality, moving beyond traditional EHR-only approaches to build more holistic health…