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Motivation: DNA methylation is an intensely studied epigenetic mark, yet its functional role is incompletely understood. Attempts to quantitatively associate average DNA methylation to gene expression yield poor correlations outside of the…

Genomics · Quantitative Biology 2016-11-17 Chantriolnt-Andreas Kapourani , Guido Sanguinetti

Cell populations are never truly homogeneous; individual cells exist in biochemical states that define functional differences between them. New technology based on microfluidic arrays combined with multiplexed quantitative polymerase chain…

In recent years, deep learning has shown promise in predicting hypertension (HTN) from fundus images. However, most prior research has primarily focused on analyzing a single type of data, which may not capture the full complexity of HTN…

Image and Video Processing · Electrical Eng. & Systems 2024-03-26 Mohammed Baharoon , Hessa Almatar , Reema Alduhayan , Tariq Aldebasi , Badr Alahmadi , Yahya Bokhari , Mohammed Alawad , Ahmed Almazroa , Abdulrhman Aljouie

Inferring the structure of gene regulatory networks (GRN) from gene expression data has many applications, from the elucidation of complex biological processes to the identification of potential drug targets. It is however a notoriously…

Machine Learning · Statistics 2012-05-08 Anne-Claire Haury , Fantine Mordelet , Paola Vera-Licona , Jean-Philippe Vert

Medical large vision-language Models (Med-LVLMs) have shown promise in clinical applications but suffer from factual inaccuracies and unreliable outputs, posing risks in real-world diagnostics. While RAG has emerged as a potential solution,…

Computation and Language · Computer Science 2026-05-05 Zhe Chen , Yusheng Liao , Zhiyuan Zhu , Haolin Li , Hongcheng Liu , Yanfeng Wang , Yu Wang

Background: Haplotypes, the ordered lists of single nucleotide variations that distinguish chromosomal sequences from their homologous pairs, may reveal an individual's susceptibility to hereditary and complex diseases and affect how our…

Social and Information Networks · Computer Science 2019-11-28 Abishek Sankararaman , Haris Vikalo , François Baccelli

Pathologist-defined labels are the gold standard for histopathological data sets, regardless of well-known limitations in consistency for some tasks. To date, some datasets on mitotic figures are available and were used for development of…

Computer Vision and Pattern Recognition · Computer Science 2020-10-22 Christof A. Bertram , Mitko Veta , Christian Marzahl , Nikolas Stathonikos , Andreas Maier , Robert Klopfleisch , Marc Aubreville

In this paper, we develop a deep learning-based bandwidth allocation policy that is: 1) scalable with the number of users and 2) transferable to different communication scenarios, such as non-stationary wireless channels, different…

Networking and Internet Architecture · Computer Science 2025-11-04 Xin Hao , Changyang She , Phee Lep Yeoh , Yuhong Liu , Branka Vucetic , Yonghui Li

RNA-Seq technology allows for studying the transcriptional state of the cell at an unprecedented level of detail. Beyond quantification of whole-gene expression, it is now possible to disentangle the abundance of individual alternatively…

Genomics · Quantitative Biology 2012-10-11 Barbara Rakitsch , Christoph Lippert , Hande Topa , Karsten Borgwardt , Antti Honkela , Oliver Stegle

In many learning applications, data are collected from multiple sources, each providing a \emph{batch} of samples that by itself is insufficient to learn its input-output relationship. A common approach assumes that the sources fall in one…

Machine Learning · Computer Science 2023-09-06 Ayush Jain , Rajat Sen , Weihao Kong , Abhimanyu Das , Alon Orlitsky

Decreasing costs and new technologies have led to an increase in the amount of data available to plant breeding programs. High-throughput phenotyping (HTP) platforms routinely generate high-dimensional datasets of secondary features that…

Next-generation RNA sequencing (RNA-seq) technology has been widely used to assess full-length RNA isoform abundance in a high-throughput manner. RNA-seq data offer insight into gene expression levels and transcriptome structures, enabling…

Applications · Statistics 2021-12-01 Wei Vivian Li , Anqi Zhao , Shihua Zhang , Jingyi Jessica Li

A wide range of studies in population genetics have employed the sample frequency spectrum (SFS), a summary statistic which describes the distribution of mutant alleles at a polymorphic site in a sample of DNA sequences. In particular,…

Probability · Mathematics 2016-03-03 John A. Kamm , Jonathan Terhorst , Yun S. Song

A novel framework, called InterGridNet, is introduced, leveraging a shallow RawNet model for geolocation classification of Electric Network Frequency (ENF) signatures in the SP Cup 2016 dataset. During data preparation, recordings are…

Human behavior presents significant challenges for data-driven approaches and machine learning, particularly in modeling the emergent and complex dynamics observed in social dilemmas. These challenges complicate the accurate prediction of…

Physics and Society · Physics 2024-12-17 Huaiyu Tan , Yikang Lu , Alfonso de Miguel-Arribas , Lei Shi

Quantitative proteomics plays a central role in uncovering regulatory mechanisms, identifying disease biomarkers, and guiding the development of precision therapies. These insights are often obtained through complex Bayesian models, whose…

Quantitative Methods · Quantitative Biology 2025-09-11 Matthew Carter , Lee Devlin , Alexander Philips , Edward Pyzer-Knapp , Paul Spirakis , Simon Maskell

This paper addresses the problem of audio scenes classification and contributes to the state of the art by proposing a novel feature. We build this feature by considering histogram of gradients (HOG) of time-frequency representation of an…

Sound · Computer Science 2015-08-21 Alain Rakotomamonjy , Gilles Gasso

Community search is a personalized community discovery problem designed to identify densely connected subgraphs containing the query node. Recently, community search in heterogeneous information networks (HINs) has received considerable…

Social and Information Networks · Computer Science 2024-07-23 Guoxin Chen , Fangda Guo , Yongqing Wang , Yanghao Liu , Peiying Yu , Huawei Shen , Xueqi Cheng

Accurate prognosis of a tumor can help doctors provide a proper course of treatment and, therefore, save the lives of many. Traditional machine learning algorithms have been eminently useful in crafting prognostic models in the last few…

Image and Video Processing · Electrical Eng. & Systems 2022-02-28 Numan Saeed , Roba Al Majzoub , Ikboljon Sobirov , Mohammad Yaqub

The Cancer Genome Atlas (TCGA) provides researchers with clinicopathological data and genomic characterizations of various carcinomas. These data sets include expression microarrays for genes and microRNAs -- short, non-coding strands of…

Quantitative Methods · Quantitative Biology 2013-07-05 Siddharth G. Reddy , Weimin Xiao , Preethi H. Gunaratne