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Recognizing the need for explainable AI (XAI) approaches to enable the successful integration of AI-based ECG prediction models (AI-ECG) into clinical practice, we introduce a framework generating \textbf{Co}unter\textbf{F}actual…

Artificial Intelligence · Computer Science 2025-08-25 Jong-Hwan Jang , Junho Song , Yong-Yeon Jo

Electrocardiography (ECG) is the clinical standard for cardiac assessment but requires dedicated hardware that does not scale to daily-life monitoring. Photoplethysmography (PPG) is ubiquitous in wearables but lacks ECG-specific diagnostic…

Signal Processing · Electrical Eng. & Systems 2026-05-14 Xiaoda Wang , Minxiao Wang , Kaiqiao Han , Defu Cao , Ching Chang , Yidan Shi , Runze Yan , Xiao Luo , Yan Liu , Xiao Hu , Yizhou Sun , Wei Wang , Carl Yang

In this paper, we present a systematic literature review on deep generative models for physiological signals, particularly electrocardiogram (ECG), electroencephalogram (EEG), photoplethysmogram (PPG) and electromyogram (EMG). Compared to…

Machine Learning · Computer Science 2025-04-11 Nour Neifar , Afef Mdhaffar , Achraf Ben-Hamadou , Mohamed Jmaiel

Breathing rate (BR), minute ventilation (VE), and other respiratory parameters are essential for real-time patient monitoring in many acute health conditions, such as asthma. The clinical standard for measuring respiration, namely…

Signal Processing · Electrical Eng. & Systems 2020-11-26 Ridwan Alam , David B. Peden , John C. Lach

High-frequency physiological waveform modality offers deep, real-time insights into patient status. Recently, physiological foundation models based on Photoplethysmography (PPG), such as PPG-GPT, have been shown to predict critical events,…

Machine Learning · Computer Science 2025-09-29 Saurabh Kataria , Davood Fattahi , Minxiao Wang , Ran Xiao , Matthew Clark , Timothy Ruchti , Mark Mai , Xiao Hu

Wearable sensor data offer opportunities for personalized health monitoring, yet deriving actionable insights from their complex, longitudinal data streams is challenging. This paper introduces a framework to learn personalized…

Machine Learning · Computer Science 2025-08-21 Ajan Subramanian , Amir M. Rahmani

Machine learning models perform well on several healthcare tasks and can help reduce the burden on the healthcare system. However, the lack of explainability is a major roadblock to their adoption in hospitals. \textit{How can the decision…

Machine Learning · Computer Science 2023-06-13 Supriya Nagesh , Nina Mishra , Yonatan Naamad , James M. Rehg , Mehul A. Shah , Alexei Wagner

Counterfactual explanations (CEs) aim to enhance the interpretability of machine learning models by illustrating how alterations in input features would affect the resulting predictions. Common CE approaches require an additional model and…

Computer Vision and Pattern Recognition · Computer Science 2024-10-02 Matan Atad , David Schinz , Hendrik Moeller , Robert Graf , Benedikt Wiestler , Daniel Rueckert , Nassir Navab , Jan S. Kirschke , Matthias Keicher

In the evolving landscape of ECG signal analysis, the challenge of limited transparency in machine learning models remains a significant barrier to their effective integration into clinical practice. This study addresses this issue by…

Signal Processing · Electrical Eng. & Systems 2024-12-09 Toygar Tanyel , Sezgin Atmaca , Kaan Gökçe , M. Yiğit Balık , Arda Güler , Emre Aslanger , İlkay Öksüz

Currently, machine learning is widely used across various domains, including time series data analysis. However, some machine learning models function as black boxes, making interpretability a critical concern. One approach to address this…

Machine Learning · Computer Science 2025-12-01 Keita Kinjo

Electrocardiography (ECG), an electrical measurement which captures cardiac activities, is the gold standard for diagnosing cardiovascular disease (CVD). However, ECG is infeasible for continuous cardiac monitoring due to its requirement…

Signal Processing · Electrical Eng. & Systems 2022-12-06 Ella Lan

Objective: To develop and interpret a supervised variational autoencoder (VAE) model for classifying cardiotocography (CTG) signals based on pregnancy outcomes, addressing interpretability limits of current deep learning approaches.…

Machine Learning · Computer Science 2025-09-09 John Tolladay , Beth Albert , Gabriel Davis Jones

The application of counterfactual explanation (CE) techniques in the realm of electroencephalography (EEG) classification has been relatively infrequent in contemporary research. In this study, we attempt to introduce and explore a novel…

Signal Processing · Electrical Eng. & Systems 2023-12-18 Kang Yin , Hye-Bin Shin , Hee-Dong Kim , Seong-Whan Lee

Cardiovascular signals such as photoplethysmography (PPG), electrocardiography (ECG), and blood pressure (BP) are inherently correlated and complementary, together reflecting the health of cardiovascular system. However, their joint…

Machine Learning · Computer Science 2025-08-22 Zehua Chen , Yuyang Miao , Liyuan Wang , Luyun Fan , Danilo P. Mandic , Jun Zhu

Biomedical signals often comprise multiple non-sinusoidal oscillatory components whose amplitude modulation (AM) and instantaneous frequency (IF) may themselves be governed by additional (second-order) oscillatory dynamics with time-varying…

Applications · Statistics 2026-05-05 Jennifer Laine , Hau-Tieng Wu

Photoplethysmogram (PPG) and electrocardiogram (ECG) are commonly recorded in intesive care unit (ICU) and operating room (OR). However, the high incidence of poor, incomplete, and inconsistent signal quality, can lead to false alarms or…

Machine Learning · Computer Science 2025-09-16 Zongheng Guo , Tao Chen , Manuela Ferrario

Due to the common content of anatomy, radiology images with their corresponding reports exhibit high similarity. Such inherent data bias can predispose automatic report generation models to learn entangled and spurious representations…

Computer Vision and Pattern Recognition · Computer Science 2024-07-22 Mingjie Li , Haokun Lin , Liang Qiu , Xiaodan Liang , Ling Chen , Abdulmotaleb Elsaddik , Xiaojun Chang

Machine learning models, particularly deep neural networks, have demonstrated strong performance in classifying complex time series data. However, their black-box nature limits trust and adoption, especially in high-stakes domains such as…

Machine Learning · Computer Science 2025-12-23 Justin Li , Efe Sencan , Jasper Zheng Duan , Vitus J. Leung , Stephen Tsaur , Ayse K. Coskun

Photoplethysmography (PPG) has become a ubiquitous physiological signal; however, current generative models still struggle to preserve realistic waveform morphology and learn a latent structure that captures cardiac and respiratory…

Signal Processing · Electrical Eng. & Systems 2026-05-25 Fatemeh Ghasemi Balouei , Nathan Willemsen , Mahesh Banavar , Bahman Moraffah

The ability to accurately perform counterfactual inference on time series is crucial for decision-making in fields like finance, healthcare, and marketing, as it allows us to understand the impact of events or treatments on outcomes over…

Machine Learning · Computer Science 2026-02-18 Tomàs Garriga , Gerard Sanz , Eduard Serrahima de Cambra , Axel Brando
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