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The human brain contains approximately $10^9$ neurons, each with approximately $10^3$ connections, synapses, with other neurons. Most sensory, cognitive and motor functions of our brains depend on the interaction of a large population of…

Neurons and Cognition · Quantitative Biology 2021-08-30 Bülent Karasözen

In nanopore technology, the development of multiplexed detection and release platforms with high spatial and temporal resolution remains a significant challenge due to the difficulty in distinguishing signals originating from different…

Applied Physics · Physics 2025-10-16 Ali Douaki , Shukun Weng , Silvia Dante , Nako Nakatsuka , Makusu Tsutsui , Roman Krahne , Denis Garoli

We introduce a novel electro-optomechanic neural sensor for realizing ultra-compact neural recording probes that can detect and relay electrophysiology signals from within neural tissue. This technology addresses outstanding challenges…

To understand Working of Human Brain measurements related to the brain function are required. These measurements should be possibly non-invasive. Brain should be disturbed as less as possible during the measurement. Integration of various…

Emerging Technologies · Computer Science 2015-06-16 Revati Shriram , M. Sundhararajan , Nivedita Daimiwal

Biological studies on in vitro cell cultures are of fundamental importance to investigate cells response to external stimuli, such as new drugs for treatment of specific pathologies, or to study communication between electrogenic cells.…

Implicit Neural Representations (INRs) are nowadays used to represent multimedia signals across various real-life applications, including image super-resolution, image compression, or 3D rendering. Existing methods that leverage INRs are…

Machine Learning · Computer Science 2023-06-21 Filip Szatkowski , Karol J. Piczak , Przemysław Spurek , Jacek Tabor , Tomasz Trzciński

Hyperpolarized nuclear magnetic resonance and lab-on-a-chip microfluidics are two dynamic, but until recently quite distinct, fields of research. Recent developments in both areas increased their synergistic overlap. By microfluidic…

Chemical Physics · Physics 2021-09-29 James Eills , William Hale , Marcel Utz

Deep learning (DL) has achieved remarkable progress in the field of medical imaging. However, adapting DL models to medical tasks remains a significant challenge, primarily due to two key factors: (1) architecture selection, as different…

Computer Vision and Pattern Recognition · Computer Science 2025-04-24 Lotfi Abdelkrim Mecharbat , Ibrahim Almakky , Martin Takac , Mohammad Yaqub

High resolution transcranial ultrasound imaging in humans has been a persistent challenge for ultrasound due to the imaging degradation effects from aberration and reverberation. These mechanisms depend strongly on skull morphology and they…

Medical Physics · Physics 2018-11-28 Danai E. Soulioti , David Espíndola , Paul A. Dayton , Gianmarco Pinton

Background: Photoplethysmography (PPG) is a non-invasive optical sensing technique widely used to capture hemodynamic information, with broad deployment in both clinical monitoring systems and wearable devices. In recent years, the…

Artificial Intelligence · Computer Science 2026-05-06 Guangkun Nie , Jiabao Zhu , Gongzheng Tang , Deyun Zhang , Shijia Geng , Qinghao Zhao , Shenda Hong

Neuroscientists have devoted significant effort into the creation of standard brain reference atlases for high-throughput registration of anatomical regions of interest. However, variability in brain size and form across individuals poses a…

Computer Vision and Pattern Recognition · Computer Science 2019-06-10 Asim Iqbal , Romesa Khan , Theofanis Karayannis

Intense short-wavelength pulses from free-electron lasers and high-harmonic-generation sources enable diffractive imaging of individual nano-sized objects with a single x-ray laser shot. The enormous data sets with up to several million…

Neural networks are a prominent tool for identifying and modeling complex patterns, which are otherwise hard to detect and analyze. While machine learning and neural networks have been finding applications across many areas of science and…

Computational Physics · Physics 2021-06-25 Nikolai D. Klimkin , Álvaro Jiménez-Galán , Rui E. F. Silva , Misha Ivanov

On-device deep learning models have extensive real world demands. Deep learning compilers efficiently compile models into executables for deployment on edge devices, but these executables may face the threat of reverse engineering. Previous…

Machine Learning · Computer Science 2025-11-04 Yilin Li , Guozhu Meng , Mingyang Sun , Yanzhong Wang , Kun Sun , Hailong Chang , Yuekang Li

Current techniques of neuroimaging, including electrical devices, are either of low spatiotemporal resolution or invasive, impeding multiscale monitoring of brain activity at both single cell and network levels. Overcoming this issue is of…

The applications of traditional statistical feature selection methods to high-dimension, low sample-size data often struggle and encounter challenging problems, such as overfitting, curse of dimensionality, computational infeasibility, and…

Machine Learning · Statistics 2023-12-19 Kexuan Li , Fangfang Wang , Lingli Yang , Ruiqi Liu

As large language models (LLMs) become more capable, there is an urgent need for interpretable and transparent tools. Current methods are difficult to implement, and accessible tools to analyze model internals are lacking. To bridge this…

Machine Learning · Computer Science 2023-11-30 Albert Garde , Esben Kran , Fazl Barez

Progress in neuroscience constantly relies on the development of new techniques to investigate the complex dynamics of neuronal networks. An ongoing challenge is to achieve minimally-invasive and high-resolution observations of neuronal…

Mental disorders (MD) are among the top most demanding challenges in world-wide health. According to the World Health Organization, the burden of MDs continues to grow with significant impact on health and major social and human rights. A…

Neurons and Cognition · Quantitative Biology 2023-03-21 Thomas Wahl , Joséphine Riedinger , Michel Duprez , Axel Hutt

The claustrum is a thin gray matter structure in each brain hemisphere, characterized by exceptionally high connectivity with nearly all brain regions. Despite extensive animal studies on its anatomy and function and growing evidence of…

Neurons and Cognition · Quantitative Biology 2025-05-16 Steven Seung-Suk Kang , Joseph Bodenheimer , Kayley Morris , Tracey Butler
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