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Mixed-integer programming (MIP) is a well-established framework for computer-aided molecular design (CAMD). By precisely encoding the molecular space and score functions, e.g., a graph neural network, the molecular design problem is…

Computational Engineering, Finance, and Science · Computer Science 2024-11-26 Shiqiang Zhang , Christian W. Feldmann , Frederik Sandfort , Miriam Mathea , Juan S. Campos , Ruth Misener

In this paper, we present an analysis of the strength of sparse cutting-planes for mixed integer linear programs (MILP) with sparse formulations. We examine three kinds of problems: packing problems, covering problems, and more general…

Optimization and Control · Mathematics 2016-01-05 Santanu S. Dey , Marco Molinaro , Qianyi Wang

Mixed integer linear programming (MILP) is a powerful representation often used to formulate decision-making problems under uncertainty. However, it lacks a natural mechanism to reason about objects, classes of objects, and relations.…

Logic in Computer Science · Computer Science 2012-05-14 Geoffrey Gordon , Sue Ann Hong , Miroslav Dudik

Data-driven inverse optimization for mixed-integer linear programs (MILPs), which seeks to learn an objective function and constraints consistent with observed decisions, is important for building accurate mathematical models in a variety…

Optimization and Control · Mathematics 2026-02-17 Akira Kitaoka

There has been a surge of interest in learning optimal decision trees using mixed-integer programs (MIP) in recent years, as heuristic-based methods do not guarantee optimality and find it challenging to incorporate constraints that are…

Machine Learning · Computer Science 2023-02-15 Shivaram Subramanian , Wei Sun

This paper presents a scenario based robust optimization framework for short term energy scheduling in electricity intensive industrial plants, explicitly addressing uncertainty in planning decisions. The model is formulated as a two-stage…

Systems and Control · Electrical Eng. & Systems 2025-12-02 Sebastián Rojas-Innocenti , Enrique Baeyens , Alejandro Martín-Crespo , Sergio Saludes-Rodil , Fernando Frechoso Escudero

The Integrated Process Planning and Scheduling (IPPS) problem combines process route planning and shop scheduling to achieve high efficiency in manufacturing and maximize resource utilization, which is crucial for modern manufacturing…

Optimization and Control · Mathematics 2024-09-04 Hongpei Li , Han Zhang , Ziyan He , Yunkai Jia , Bo Jiang , Xiang Huang , Dongdong Ge

Influence diagnosis is an integrated component of data analysis, but is severely under-investigated in a high-dimensional setting. One of the key challenges, even in a fixed-dimensional setting, is how to deal with multiple influential…

Methodology · Statistics 2017-02-07 Junlong Zhao , Chao Liu , Lu Niu , Chenlei Leng

ReLU neural networks have been modelled as constraints in mixed integer linear programming (MILP), enabling surrogate-based optimisation in various domains and efficient solution of machine learning certification problems. However, previous…

Optimization and Control · Mathematics 2023-12-05 Tom McDonald , Calvin Tsay , Artur M. Schweidtmann , Neil Yorke-Smith

In fields such as autonomous and safety-critical systems, online optimization plays a crucial role in control and decision-making processes, often requiring the integration of continuous and discrete variables. These tasks are frequently…

Optimization and Control · Mathematics 2025-03-17 Marco Zamponi , Emilio Incerto , Daniele Masti , Mirco Tribastone

Mixed-Integer Programs (MIPs) are NP-hard optimization models that arise in a broad range of decision-making applications, including finance, logistics, energy systems, and network design. Although modern commercial solvers have achieved…

This paper addresses the problem of planning under uncertainty in large Markov Decision Processes (MDPs). Factored MDPs represent a complex state space using state variables and the transition model using a dynamic Bayesian network. This…

Artificial Intelligence · Computer Science 2011-06-10 C. Guestrin , D. Koller , R. Parr , S. Venkataraman

We consider the problem of minimizing the makespan on batch processing identical machines, subject to compatibility constraints, where two jobs are compatible if they can be processed simultaneously in a same batch. These constraints are…

Discrete Mathematics · Computer Science 2023-09-07 Khaoula Bouakaz , Mourad Boudhar

Planning the maintenance of nuclear power plants is a complex optimization problem, involving a joint optimization of maintenance dates, fuel constraints and power production decisions. This paper investigates Mixed Integer Linear…

Artificial Intelligence · Computer Science 2020-09-08 Nicolas Dupin , El-Ghazali Talbi

We solve large-scale mixed-integer linear programs (MILPs) via distributed asynchronous saddle point computation. This is motivated by the MILPs being able to model problems in multi-agent autonomy, e.g., task assignment problems and…

Optimization and Control · Mathematics 2022-11-23 Luke Fina , Matthew Hale

We study logit-based multi-purchase choice models and develop an exact solution methodology for the resulting assortment optimization problems, which we show are NP-hard to approximate. We introduce a hypergraph representation that captures…

Optimization and Control · Mathematics 2026-03-30 Taotao He , Zhongqi Wu , Yating Zhang

This paper addresses a production scheduling problem derived from an industrial use case, focusing on unrelated parallel machine scheduling with the personnel availability constraint. The proposed model optimizes the production plan over a…

Artificial Intelligence · Computer Science 2024-02-27 Maziyar Khadivi , Mostafa Abbasi , Todd Charter , Homayoun Najjaran

Integer linear programming (ILP) encompasses a very important class of optimization problems that are of great interest to both academia and industry. Several algorithms are available that attempt to explore the solution space of this class…

Emerging Technologies · Computer Science 2018-08-31 Fabio L. Traversa , Massimiliano Di Ventra

Solving (mixed) integer linear programs, (M)ILPs for short, is a fundamental optimization task. While hard in general, recent years have brought about vast progress for solving structurally restricted, (non-mixed) ILPs: $n$-fold, tree-fold,…

Data Structures and Algorithms · Computer Science 2019-12-10 Cornelius Brand , Martin Koutecký , Sebastian Ordyniak

Mixed-integer linear programming (MILP), a widely used modeling framework for combinatorial optimization, are central to many scientific and engineering applications, yet remains computationally challenging at scale. Recent advances in deep…

Artificial Intelligence · Computer Science 2026-01-09 Peixin Huang , Yaoxin Wu , Yining Ma , Cathy Wu , Wen Song , Wei Zhang