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For machine learning-based prognosis and diagnosis of rare diseases, such as pediatric brain tumors, it is necessary to gather medical imaging data from multiple clinical sites that may use different devices and protocols. Deep…

Magnetic resonance imaging (MRI) has greatly advanced neuroscience research and clinical diagnostics. However, imaging data collected across different scanners, acquisition protocols, or imaging sites often exhibit substantial…

Image and Video Processing · Electrical Eng. & Systems 2026-04-02 Qinqin Yang , Firoozeh Shomal-Zadeh , Ali Gholipour

Multi-site structural MRI is increasingly used in neuroimaging studies to diversify subject cohorts. However, combining MR images acquired from various sites/centers may introduce site-related non-biological variations. Retrospective image…

Image and Video Processing · Electrical Eng. & Systems 2024-08-20 Mengqi Wu , Minhui Yu , Shuaiming Jing , Pew-Thian Yap , Zhengwu Zhang , Mingxia Liu

In MRI, variations in scan parameters, sequence, or hardware can lead to discrepancies in image appearance, even for the same subject. These inconsistencies, known as domain shifts, can hinder image analysis and degrade the performance of…

Image and Video Processing · Electrical Eng. & Systems 2026-05-05 Minjun Kim , Dong Ju Mun , Hwihun Jeong , Hangyeol Park , Haechang Lee , Se Young Chun , Jongho Lee

Synthesizing missing modalities in multi-modal magnetic resonance imaging (MRI) is vital for ensuring diagnostic completeness, particularly when full acquisitions are infeasible due to time constraints, motion artifacts, and patient…

Computer Vision and Pattern Recognition · Computer Science 2026-02-24 Yue Zhang , Zhizheng Zhuo , Siyao Xu , Shan Lv , Zhaoxi Liu , Jun Qiu , Qiuli Wang , Yaou Liu , S. Kevin Zhou

Multi-site MRI studies often suffer from site-specific variations arising from differences in methodology, hardware, and acquisition protocols, thereby compromising accuracy and reliability in clinical AI/ML tasks. We present PRISM…

Image and Video Processing · Electrical Eng. & Systems 2024-11-12 Sarang Galada , Tanurima Halder , Kunal Deo , Ram P Krish , Kshitij Jadhav

In clinical practice, medical segmentation datasets are often limited and heterogeneous, with variations in modalities, protocols, and anatomical targets across institutions. Existing deep learning models struggle to jointly learn from such…

Computer Vision and Pattern Recognition · Computer Science 2026-01-22 Weiwei Ma , Xiaobing Yu , Peijie Qiu , Jin Yang , Pan Xiao , Xiaoqi Zhao , Xiaofeng Liu , Tomo Miyazaki , Shinichiro Omachi , Yongsong Huang

Harmonization improves data consistency and is central to effective integration of diverse imaging data acquired across multiple sites. Recent deep learning techniques for harmonization are predominantly supervised in nature and hence…

Image and Video Processing · Electrical Eng. & Systems 2021-10-04 Siyuan Liu , Pew-Thian Yap

The variability introduced by differences in MRI scanner models, acquisition protocols, and imaging sites hinders consistent analysis and generalizability across multicenter studies. We present a novel image-based harmonization framework…

Computer Vision and Pattern Recognition · Computer Science 2025-10-28 Luca Caldera , Lara Cavinato , Francesca Ieva

We propose a new framework, called Hierarchical Multi-resolution Mesh Networks (HMMNs), which establishes a set of brain networks at multiple time resolutions of fMRI signal to represent the underlying cognitive process. The suggested…

Neural and Evolutionary Computing · Computer Science 2017-01-13 Itir Onal Ertugrul , Mete Ozay , Fatos Tunay Yarman Vural

Structural magnetic resonance imaging (sMRI) provides accurate estimates of the brain's structural organization and learning invariant brain representations from sMRI is an enduring issue in neuroscience. Previous deep representation…

Computer Vision and Pattern Recognition · Computer Science 2023-06-21 Ning Jiang , Gongshu Wang , Tianyi Yan

Multisequence Magnetic Resonance Imaging (MRI) provides a more reliable diagnosis in clinical applications through complementary information across sequences. However, in practice, the absence of certain MR sequences is a common problem…

Image and Video Processing · Electrical Eng. & Systems 2025-10-21 Jihoon Cho , Jonghye Woo , Jinah Park

Ultrahigh field (UHF) Magnetic Resonance Imaging (MRI) provides a higher signal-to-noise ratio and, thereby, higher spatial resolution. However, UHF MRI introduces challenges such as transmit radiofrequency (RF) field (B1+) inhomogeneities,…

Computer Vision and Pattern Recognition · Computer Science 2025-02-07 Zhengyi Lu , Hao Liang , Xiao Wang , Xinqiang Yan , Yuankai Huo

In MRI, images of the same contrast (e.g., T$_1$) from the same subject can exhibit noticeable differences when acquired using different hardware, sequences, or scan parameters. These differences in images create a domain gap that needs to…

Image and Video Processing · Electrical Eng. & Systems 2023-08-17 Hwihun Jeong , Heejoon Byun , Dong Un Kang , Jongho Lee

Brain magnetic resonance imaging (MRI) has been extensively employed across clinical and research fields, but often exhibits sensitivity to site effects arising from non-biological variations such as differences in field strength and…

Image and Video Processing · Electrical Eng. & Systems 2024-05-31 Mengqi Wu , Lintao Zhang , Pew-Thian Yap , Hongtu Zhu , Mingxia Liu

Retrospective MRI harmonization is limited by poor scalability across modalities and reliance on traveling subject datasets. To address these challenges, we introduce IHF-Harmony, a unified invertible hierarchy flow framework for…

Computer Vision and Pattern Recognition · Computer Science 2026-05-18 Pengli Zhu , Yitao Zhu , Haowen Pang , Anqi Qiu

Automatic segmentation of diverse heterogeneous brain lesions using multi-modal MRI is a challenging problem in clinical neuroimaging, mainly because of the lack of generalizability and high prediction variance of pathology-specific deep…

Computer Vision and Pattern Recognition · Computer Science 2026-02-24 Md. Mehedi Hassan , Shafqat Alam , Shahriar Ahmed Seam , Maruf Ahmed

Brain tumor segmentation requires accurate identification of hierarchical regions including whole tumor (WT), tumor core (TC), and enhancing tumor (ET) from multi-sequence magnetic resonance imaging (MRI) images. Due to tumor tissue…

Computer Vision and Pattern Recognition · Computer Science 2025-09-23 Mingda Zhang , Yuyang Zheng , Ruixiang Tang , Jingru Qiu , Haiyan Ding

Accuracy and consistency are two key factors in computer-assisted magnetic resonance (MR) image analysis. However, contrast variation from site to site caused by lack of standardization in MR acquisition impedes consistent measurements. In…

Image and Video Processing · Electrical Eng. & Systems 2021-03-25 Lianrui Zuo , Blake E. Dewey , Aaron Carass , Yihao Liu , Yufan He , Peter A. Calabresi , Jerry L. Prince

Magnetic resonance imaging (MRI) image segmentation is crucial in diagnosing and treating many diseases, such as brain tumors. Existing MRI image segmentation methods mainly fall into a centralized multimodal paradigm, which is inapplicable…

Computer Vision and Pattern Recognition · Computer Science 2026-03-10 Guyue Hu , Siyuan Song , Jingpeng Sun , Zhe Jin , Chenglong Li , Jin Tang
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