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We propose SymDiff, a method for constructing equivariant diffusion models using the framework of stochastic symmetrisation. SymDiff resembles a learned data augmentation that is deployed at sampling time, and is lightweight,…

Machine Learning · Computer Science 2025-03-04 Leo Zhang , Kianoosh Ashouritaklimi , Yee Whye Teh , Rob Cornish

The crystal diffusion variational autoencoder (CDVAE) is a machine learning model that leverages score matching to generate realistic crystal structures that preserve crystal symmetry. In this study, we leverage novel diffusion…

Prediction of stable crystal structures at given pressure-temperature conditions, based only on the knowledge of the chemical composition, is a central problem of condensed matter physics. This extremely challenging problem is often termed…

Materials Science · Physics 2015-05-20 A. R. Oganov , Y. Ma , A. O. Lyakhov , M. Valle , C. Gatti

We show how generative machine learning can be used for the rapid computation of strongly dynamical electron diffraction directly from crystal structures, specifically in large-angle convergent-beam electron diffraction (LACBED) patterns.…

Materials Science · Physics 2025-07-31 Joseph J. Webb , Richard Beanland , Rudolf A. Römer

The discovery of new materials is essential for enabling technological advancements. Computational approaches for predicting novel materials must effectively learn the manifold of stable crystal structures within an infinite design space.…

The generation of plausible crystal structures is often the first step in predicting the structure and properties of a material from its chemical composition. Quickly generating and predicting inorganic crystal structures is important for…

Materials Science · Physics 2024-02-13 Luis M. Antunes , Keith T. Butler , Ricardo Grau-Crespo

Diffusion models conditioned on identity embeddings enable the generation of synthetic face images that consistently preserve identity across multiple samples. Recent work has shown that introducing an additional negative condition through…

Graphics · Computer Science 2026-04-01 Eduarda Caldeira , Tahar Chettaoui , Naser Damer , Fadi Boutros

Crystal structures can be viewed as assemblies of space-filling polyhedra, which play a critical role in determining material properties such as ionic conductivity and dielectric constant. However, most conventional crystal structure…

Materials Science · Physics 2026-03-20 Tomoyasu Yokoyama , Kazuhide Ichikawa , Hisashi Naito

Inverse design of inorganic crystals, in which structures are generated to satisfy a target property while preserving diversity and physical plausibility, remains more demanding than ab initio generation, as property conditioning can…

Materials Science · Physics 2026-05-05 Ibuki Okuda , Izumi Takahara , Teruyasu Mizoguchi

Generative modeling of crystal data distribution is an important yet challenging task due to the unique periodic physical symmetry of crystals. Diffusion-based methods have shown early promise in modeling crystal distribution. More…

Machine Learning · Computer Science 2025-02-05 Hanlin Wu , Yuxuan Song , Jingjing Gong , Ziyao Cao , Yawen Ouyang , Jianbing Zhang , Hao Zhou , Wei-Ying Ma , Jingjing Liu

Spatial profiling technologies in biology, such as imaging mass cytometry (IMC) and spatial transcriptomics (ST), generate high-dimensional, multi-channel data with strong spatial alignment and complex inter-channel relationships.…

Machine Learning · Computer Science 2025-07-08 Haoran Zhang , Mingyuan Zhou , Wesley Tansey

We introduce SynFormer, a generative modeling framework designed to efficiently explore and navigate synthesizable chemical space. Unlike traditional molecular generation approaches, we generate synthetic pathways for molecules to ensure…

Machine Learning · Computer Science 2024-10-07 Wenhao Gao , Shitong Luo , Connor W. Coley

Organic molecular crystals underpin technologies ranging from pharmaceuticals to organic electronics, yet predicting solid-state packing of molecules remains challenging because candidate generation is combinatorial and stability is only…

Advancements in generative models have sparked significant interest in generating images while adhering to specific structural guidelines. Scene graph to image generation is one such task of generating images which are consistent with the…

Computer Vision and Pattern Recognition · Computer Science 2024-07-23 Rameshwar Mishra , A V Subramanyam

Generative models have achieved remarkable success in image, video, and text domains. Inspired by this, researchers have explored utilizing generative models to generate neural network parameters. However, these efforts have been limited by…

Artificial Intelligence · Computer Science 2024-08-05 Xiaolong Jin , Kai Wang , Dongwen Tang , Wangbo Zhao , Yukun Zhou , Junshu Tang , Yang You

Crystal structure prediction is a long-standing challenge in materials science, with most data-driven methods developed for inorganic systems. This leaves an important gap for organic crystals, which are central to pharmaceuticals,…

Materials Science · Physics 2026-02-25 Mohammadmahdi Vahediahmar , Matthew A. McDonald , Feng Liu

We introduce Spectral Guidance, a framework for controlling diffusion models by leveraging the intrinsic geometry of the generative process. As data is progressively corrupted by noise, only a small number of features remain informative for…

Machine Learning · Computer Science 2026-05-29 Gabriel Moreira , Manuel Marques , João Paulo Costeira , Chenyan Xiong

Correctly capturing the symmetry transformations of data can lead to efficient models with strong generalization capabilities, though methods incorporating symmetries often require prior knowledge. While recent advancements have been made…

The task of deducing three-dimensional molecular configurations from their two-dimensional graph representations holds paramount importance in the fields of computational chemistry and pharmaceutical development. The rapid advancement of…

Biomolecules · Quantitative Biology 2025-01-09 Bobin Yang , Jie Deng , Zhenghan Chen , Ruoxue Wu

This paper proposes DiffPF, a differentiable particle filter that leverages diffusion models for state estimation in dynamic systems. Unlike conventional differentiable particle filters, which require importance weighting and typically rely…

Robotics · Computer Science 2026-01-13 Ziyu Wan , Lin Zhao
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