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We address the problem of synthetic gene design using Bayesian optimization. The main issue when designing a gene is that the design space is defined in terms of long strings of characters of different lengths, which renders the…

Machine Learning · Statistics 2015-05-08 Javier González , Joseph Longworth , David C. James , Neil D. Lawrence

We revisit the complexity of the classical Interval Scheduling in the dynamic setting. In this problem, the goal is to maintain a set of intervals under insertions and deletions and report the size of the maximum size subset of pairwise…

Data Structures and Algorithms · Computer Science 2022-10-04 Paweł Gawrychowski , Karol Pokorski

The single-cell RNA sequencing (scRNA-seq) technology enables researchers to study complex biological systems and diseases with high resolution. The central challenge is synthesizing enough scRNA-seq samples; insufficient samples can impede…

Genomics · Quantitative Biology 2023-12-25 Yixuan Wang , Shuangyin Li , Shimin DI , Lei Chen

We consider parametric version of fixed-delay continuous-time Markov chains (or equivalently deterministic and stochastic Petri nets, DSPN) where fixed-delay transitions are specified by parameters, rather than concrete values. Our goal is…

Performance · Computer Science 2016-04-18 Tomáš Brázdil , Ľuboš Korenčiak , Jan Krčál , Petr Novotný , Vojtěch Řehák

Given a set of interacting components with non-deterministic variable update and given safety requirements, the goal of priority synthesis is to restrict, by means of priorities, the set of possible interactions in such a way as to…

Logic in Computer Science · Computer Science 2012-01-30 Chih-Hong Cheng , Saddek Bensalem , Rongjie Yan , Harald Ruess , Christian Buckl , Alois Knoll

Synthetic Data Generation (SDG), leveraging Large Language Models (LLMs), has recently been recognized and broadly adopted as an effective approach to improve the performance of smaller but more resource and compute efficient LLMs through…

Machine Learning · Computer Science 2026-03-25 Srideepika Jayaraman , Achille Fokoue , Dhaval Patel , Jayant Kalagnanam

Program synthesis from input-output (IO) examples has been a long-standing challenge. While recent works demonstrated limited success on domain-specific languages (DSL), it remains highly challenging to apply them to real-world programming…

Programming Languages · Computer Science 2021-11-23 Xinyun Chen , Dawn Song , Yuandong Tian

Printing custom DNA sequences is essential to scientific and biomedical research, but the technology can be used to manufacture plagues as well as cures. Just as ink printers recognize and reject attempts to counterfeit money, DNA…

We introduce a framework for the control of discrete-time switched stochastic systems with uncertain distributions. In particular, we consider stochastic dynamics with additive noise whose distribution lies in an ambiguity set of…

Systems and Control · Electrical Eng. & Systems 2024-05-21 Ibon Gracia , Dimitris Boskos , Morteza Lahijanian , Luca Laurenti , Manuel Mazo

This letter proposes a learning-based bounded synthesis for a semi-Markov decision process (SMDP) with a linear temporal logic (LTL) specification. In the product of the SMDP and the deterministic $K$-co-B\"uchi automaton (d$K$cBA)…

Systems and Control · Electrical Eng. & Systems 2022-04-12 Ryohei Oura , Toshimitsu Ushio

We address the problem of designing stabilizing control policies for nonlinear systems in discrete-time, while minimizing an arbitrary cost function. When the system is linear and the cost is convex, the System Level Synthesis (SLS)…

Systems and Control · Electrical Eng. & Systems 2023-01-03 Luca Furieri , Clara Lucía Galimberti , Giancarlo Ferrari-Trecate

Modern deep learning models in computer vision require large datasets of real images, which are difficult to curate and pose privacy and legal concerns, limiting their commercial use. Recent works suggest synthetic data as an alternative,…

Computer Vision and Pattern Recognition · Computer Science 2025-06-25 Farnood Salehi , Vandit Sharma , Amirhossein Askari Farsangi , Tunç Ozan Aydın

Automatic software generation based on some specification is known as program synthesis. Most existing approaches formulate program synthesis as a search problem with discrete parameters. In this paper, we present a novel formulation of…

Artificial Intelligence · Computer Science 2023-04-04 Shantanu Mandal , Todd A. Anderson , Javier Turek , Justin Gottschlich , Abdullah Muzahid

System Level Synthesis (SLS) parametrization facilitates controller synthesis for large, complex, and distributed systems by incorporating system level constraints (SLCs) into a convex SLS problem and mapping its solution to stable…

Systems and Control · Electrical Eng. & Systems 2021-01-14 Shih-Hao Tseng , Carmen {Amo Alonso} , SooJean Han

We study approximation algorithms for the following three string measures that are widely used in practice: edit distance (ED), longest common subsequence (LCS), and longest increasing sequence (LIS). All three problems can be solved…

Data Structures and Algorithms · Computer Science 2020-07-28 Kuan Cheng , Zhengzhong Jin , Xin Li , Yu Zheng

The automatic generation of computer programs is one of the main applications with practical relevance in the field of evolutionary computation. With program synthesis techniques not only software developers could be supported in their…

Neural and Evolutionary Computing · Computer Science 2021-08-30 Dominik Sobania , Dirk Schweim , Franz Rothlauf

Convolutional Neural Networks (CNN) based image reconstruction methods have been intensely used for X-ray computed tomography (CT) reconstruction applications. Despite great success, good performance of this data-based approach critically…

Computer Vision and Pattern Recognition · Computer Science 2019-01-31 Ziling Wu , Abdulaziz Alorf , Ting Yang , Ling Li , Yunhui Zhu

We study the amount of reliable information that can be stored in a DNA-based storage system with noisy sequencing, where each codeword is composed of short DNA molecules. We analyze a concatenated coding scheme, where the outer code is…

Information Theory · Computer Science 2026-05-19 Ran Tamir , Nir Weinberger , Albert Guillén i Fàbregas

Multi-sequence MRI is valuable in clinical settings for reliable diagnosis and treatment prognosis, but some sequences may be unusable or missing for various reasons. To address this issue, MRI synthesis is a potential solution. Recent deep…

Image and Video Processing · Electrical Eng. & Systems 2023-07-04 Luyi Han , Tianyu Zhang , Yunzhi Huang , Haoran Dou , Xin Wang , Yuan Gao , Chunyao Lu , Tan Tao , Ritse Mann

Biological and advanced cyberphysical control systems often have limited, sparse, uncertain, and distributed communication and computing in addition to sensing and actuation. Fortunately, the corresponding plants and performance…

Systems and Control · Electrical Eng. & Systems 2019-07-08 Yuh-Shyang Wang , Nikolai Matni , John C. Doyle