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Mechanistic, multicellular, agent-based models are commonly used to investigate tissue, organ, and organism-scale biology at single-cell resolution. The Cellular-Potts Model (CPM) is a powerful and popular framework for developing and…

Quantitative Methods · Quantitative Biology 2025-10-24 Tien Comlekoglu , J. Quetzalcoatl Toledo-Marín , Douglas W. DeSimone , Shayn M. Peirce , Geoffrey Fox , James A. Glazier

We develop a systematic approach for surrogate model construction in reduced input parameter spaces. A sparse set of model evaluations in the original input space is used to approximate derivative based global sensitivity measures (DGSMs)…

Applications · Statistics 2018-06-19 Manav Vohra , Alen Alexanderian , Cosmin Safta , Sankaran Mahadevan

In neural network surrogate solvers for electromagnetic simulations, accurately modeling resonant phenomena remains a central challenge. High-amplitude resonances generate strongly localized field patterns that deviate significantly from…

Optics · Physics 2026-05-19 Sunghyun Nam , Chan Y. Park , Min Seok Jang

Among the well-known methods to approximate derivatives of expectancies computed by Monte-Carlo simulations, averages of pathwise derivatives are often the easiest one to apply. Computing them via algorithmic differentiation typically does…

Computational Physics · Physics 2024-05-14 Max Aehle , Mihály Novák , Vassil Vassilev , Nicolas R. Gauger , Lukas Heinrich , Michael Kagan , David Lange

This paper explores the challenges and benefits of a trainable destruction process in diffusion samplers -- diffusion-based generative models trained to sample an unnormalised density without access to data samples. Contrary to the majority…

Denoising diffusion models represent a recent emerging topic in computer vision, demonstrating remarkable results in the area of generative modeling. A diffusion model is a deep generative model that is based on two stages, a forward…

Computer Vision and Pattern Recognition · Computer Science 2025-01-17 Florinel-Alin Croitoru , Vlad Hondru , Radu Tudor Ionescu , Mubarak Shah

Recovering high-dimensional statistical structure from limited measurements is a fundamental challenge in hyperspectral imaging, where capturing full-resolution data is often infeasible due to sensor, bandwidth, or acquisition constraints.…

Image and Video Processing · Electrical Eng. & Systems 2025-08-01 Jonathan Monsalve , Kumar Vijay Mishra

The entry phase constitutes a design driver for aerospace systems that include such a critical step. This phase is characterized by hypersonic flows encompassing multiscale phenomena that require advanced modeling capabilities. However,…

Diffusion models (DMs) excel in image generation but suffer from slow inference and training-inference discrepancies. Although gradient-based solvers for DMs accelerate denoising inference, they often lack theoretical foundations in…

Computer Vision and Pattern Recognition · Computer Science 2026-02-04 Shigui Li , Wei Chen , Delu Zeng

In this paper, a novel surrogate model based on the Grassmannian diffusion maps (GDMaps) and utilizing geometric harmonics is developed for predicting the response of engineering systems and complex physical phenomena. The method utilizes…

Data Analysis, Statistics and Probability · Physics 2022-06-28 Ketson R. M. dos Santos , Dimitrios G. Giovanis , Katiana Kontolati , Dimitrios Loukrezis , Michael D. Shields

The original dual-readout calorimeter prototype (DREAM), constructed two decades ago, has proven instrumental in advancing our understanding of calorimetry. It has facilitated a multitude of breakthroughs by leveraging signals from…

Instrumentation and Detectors · Physics 2024-08-29 N. Akchurin , J. Cash , J. Damgov , X. Delashaw , K. Lamichhane , M. Harris , M. Kelley , S. Kunori , H. Mergate-Cacace , T. Peltola , O. Schneider , J. Sewell

Numerical simulations on fluid dynamics problems primarily rely on spatially or/and temporally discretization of the governing equation into the finite-dimensional algebraic system solved by computers. Due to complicated nature of the…

Computational Physics · Physics 2021-07-23 Luning Sun , Han Gao , Shaowu Pan , Jian-Xun Wang

With the success of image generation, generative diffusion models are increasingly adopted for discriminative tasks, as pixel generation provides a unified perception interface. However, directly repurposing the generative denoising process…

Computer Vision and Pattern Recognition · Computer Science 2025-04-16 Ziqi Pang , Xin Xu , Yu-Xiong Wang

Deep generative models, particularly denoising diffusion models, have achieved remarkable success in high-fidelity generation of architected microstructures with desired properties and styles. Nevertheless, these recent methods typically…

Computational Engineering, Finance, and Science · Computer Science 2026-01-13 Weipeng Xu , Ziyuan Xie , Haoju Lin , Xinyu Wang , Guangjin Mou , Tianju Xue

High-fidelity computational fluid dynamics (CFD) simulations are widely used to analyze nuclear reactor transients, but are computationally expensive when exploring large parameter spaces. Multifidelity surrogate models offer an approach to…

Machine Learning · Computer Science 2026-03-17 Meredith Eaheart , Majdi I. Radaideh

We present LEMURS: an extensive dataset of simulated calorimeter showers designed to support the development and benchmarking of fast simulation methods in high-energy physics, most notably providing a step towards the development of…

Instrumentation and Detectors · Physics 2025-11-04 Peter McKeown , Piyush Raikwar , Anna Zaborowska

Forecasting over graph-structured sensor networks demands models that capture both deterministic spatial trends and stochastic variability, while remaining efficient enough for repeated inference as new observations arrive. We propose…

Machine Learning · Computer Science 2026-04-02 Hanlin Dong , Arian Prabowo , Hao Xue , Ao Shuang , Tianyi Zhou , Flora D. Salim

Diffusion Probabilistic Models (DPMs) have recently shown remarkable performance in image generation tasks, which are capable of generating highly realistic images. When adopting DPMs for image restoration tasks, the crucial aspect lies in…

Computer Vision and Pattern Recognition · Computer Science 2023-06-01 Yi Zhang , Xiaoyu Shi , Dasong Li , Xiaogang Wang , Jian Wang , Hongsheng Li

Sparse-view sampling in dual-energy computed tomography (DECT) significantly reduces radiation dose and increases imaging speed, yet is highly prone to artifacts. Although diffusion models have demonstrated potential in effectively handling…

Image and Video Processing · Electrical Eng. & Systems 2025-04-11 Zini Chen , Yao Xiao , Junyan Zhang , Shaoyu Wang , Liu Shi , Qiegen Liu

Detector simulations are an exciting application of modern generative networks. Their sparse high-dimensional data combined with the required precision poses a serious challenge. We show how combining Conditional Flow Matching with…

High Energy Physics - Phenomenology · Physics 2025-03-12 Luigi Favaro , Ayodele Ore , Sofia Palacios Schweitzer , Tilman Plehn
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