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Biomedical data is inherently multimodal, consisting of electronic health records, medical imaging, digital pathology, genome sequencing, wearable sensors, and more. The application of artificial intelligence tools to these multifaceted…

Machine Learning · Computer Science 2024-08-26 Shentong Mo , Paul Pu Liang

Pathological diagnosis remains the definitive standard for identifying tumors. The rise of multimodal large models has simplified the process of integrating image analysis with textual descriptions. Despite this advancement, the substantial…

Computer Vision and Pattern Recognition · Computer Science 2024-08-14 Xiaomin Wu , Rui Xu , Pengchen Wei , Wenkang Qin , Peixiang Huang , Ziheng Li , Lin Luo

Multimodal large language models (MLLMs) have advanced clinical tasks for common conditions, but their performance on rare diseases remains largely untested. In rare-disease scenarios, clinicians often lack prior clinical knowledge, forcing…

Computer Vision and Pattern Recognition · Computer Science 2026-05-14 Junzhi Ning , Jiashi Lin , Yingying Fang , Wei Li , Jiyao Liu , Cheng Tang , Chenglong Ma , Wenhao Tang , Tianbin Li , Ziyan Huang , Guang Yang , Junjun He

Recent advances in clinical AI have enabled remarkable progress across many clinical domains. However, existing benchmarks and models are primarily limited to a small set of modalities and tasks, which hinders the development of large-scale…

Machine Learning · Computer Science 2025-03-21 Wei Dai , Peilin Chen , Malinda Lu , Daniel Li , Haowen Wei , Hejie Cui , Paul Pu Liang

Multimodal machine learning (MML) is rapidly reshaping the way mental-health disorders are detected, characterized, and longitudinally monitored. Whereas early studies relied on isolated data streams -- such as speech, text, or wearable…

Machine Learning · Computer Science 2025-06-25 Zahraa Al Sahili , Ioannis Patras , Matthew Purver

The application of the Multi-modal Large Language Models (MLLMs) in medical clinical scenarios remains underexplored. Previous benchmarks only focus on the capacity of the MLLMs in medical visual question-answering (VQA) or report…

Computation and Language · Computer Science 2024-08-19 Hongcheng Liu , Yusheng Liao , Siqv Ou , Yuhao Wang , Heyang Liu , Yanfeng Wang , Yu Wang

Most medical multimodal benchmarks focus on static tasks such as image question answering, report generation, and plain-language rewriting. Patient education is more demanding: systems must identify relevant evidence across images, show…

Artificial Intelligence · Computer Science 2026-04-17 Zonghai Yao , Zhipeng Tang , Chengtao Lin , Xiong Luo , Benlu Wang , Juncheng Huang , Chin Siang Ong , Hong Yu

Clinical check-up reports are multimodal documents that combine page layouts, tables, numerical biomarkers, abnormality flags, imaging findings, and domain-specific terminology. Such heterogeneous evidence is difficult for laypersons to…

Computation and Language · Computer Science 2026-05-14 Sike Xiang , Shuang Chen , Kevin Qinghong Lin , Jialin Yu , Yijia Sun , Philip Torr , Amir Atapour-Abarghouei

The rapid development of diagnostic technologies in healthcare is leading to higher requirements for physicians to handle and integrate the heterogeneous, yet complementary data that are produced during routine practice. For instance, the…

Machine Learning · Computer Science 2023-01-30 Can Cui , Haichun Yang , Yaohong Wang , Shilin Zhao , Zuhayr Asad , Lori A. Coburn , Keith T. Wilson , Bennett A. Landman , Yuankai Huo

Multimodal data modeling has emerged as a powerful approach in clinical research, enabling the integration of diverse data types such as imaging, genomics, wearable sensors, and electronic health records. Despite its potential to improve…

Vision-threatening eye diseases pose a major global health burden, with timely diagnosis limited by workforce shortages and restricted access to specialized care. While multimodal large language models (MLLMs) show promise for medical image…

Multimodal large language models (MLLMs) hold significant potential in medical applications, including disease diagnosis and clinical decision-making. However, these tasks require highly accurate, context-sensitive, and professionally…

Computation and Language · Computer Science 2025-09-01 Meidan Ding , Jipeng Zhang , Wenxuan Wang , Cheng-Yi Li , Wei-Chieh Fang , Hsin-Yu Wu , Haiqin Zhong , Wenting Chen , Linlin Shen

Medical data poses a daunting challenge for AI algorithms: it exists in many different modalities, experiences frequent distribution shifts, and suffers from a scarcity of examples and labels. Recent advances, including transformers and…

Current artificial intelligence models for medical imaging are predominantly single modality and single disease. Attempts to create multimodal and multi-disease models have resulted in inconsistent clinical accuracy. Furthermore, training…

Self-supervised learning has greatly facilitated medical image analysis by suppressing the training data requirement for real-world applications. Current paradigms predominantly rely on self-supervision within uni-modal image data, thereby…

Computer Vision and Pattern Recognition · Computer Science 2025-03-31 Shaohao Rui , Lingzhi Chen , Zhenyu Tang , Lilong Wang , Mianxin Liu , Shaoting Zhang , Xiaosong Wang

Artificial intelligence has demonstrated significant potential in clinical decision-making; however, developing models capable of adapting to diverse real-world scenarios and performing complex diagnostic reasoning remains a major…

Computer Vision and Pattern Recognition · Computer Science 2025-08-18 Ronghao Xu , Zhen Huang , Yangbo Wei , Xiaoqian Zhou , Zikang Xu , Ting Liu , Zihang Jiang , S. Kevin Zhou

Machine learning methods in healthcare have traditionally focused on using data from a single modality, limiting their ability to effectively replicate the clinical practice of integrating multiple sources of information for improved…

Machine Learning · Computer Science 2024-02-13 Felix Krones , Umar Marikkar , Guy Parsons , Adam Szmul , Adam Mahdi

Evaluating large language models (LLMs) in medicine is crucial because medical applications require high accuracy with little room for error. Current medical benchmarks have three main types: medical exam-based, comprehensive medical, and…

Although multimodal fusion has made significant progress, its advancement is severely hindered by the lack of adequate evaluation benchmarks. Current fusion methods are typically evaluated on a small selection of public datasets, a limited…

Machine Learning · Computer Science 2026-05-07 Leyan Xue , Changqing Zhang , Kecheng Xue , Xiaohong Liu , Guangyu Wang , Zongbo Han

Medical decision-making requires integrating diverse medical information, from imaging to clinical narratives. These medical modalities are often acquired in a many-to-many manner. However, current medical vision-language pretraining models…

Computer Vision and Pattern Recognition · Computer Science 2025-10-01 Yuan Gao , Sangwook Kim , Jianzhong You , Chris McIntosh
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