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Personalized precision radiation therapy requires more than simple classification, it demands the identification of prognostic, spatially informative features and the ability to adapt treatment based on individual response. This study…

Medical Physics · Physics 2025-06-24 Hao Peng , Steve Jiang , Robert Timmerman

Motivation: Tumor classification using Imaging Mass Spectrometry (IMS) data has a high potential for future applications in pathology. Due to the complexity and size of the data, automated feature extraction and classification steps are…

Machine Learning · Statistics 2018-06-28 Jens Behrmann , Christian Etmann , Tobias Boskamp , Rita Casadonte , Jörg Kriegsmann , Peter Maass

Multi-task neural network architectures provide a mechanism that jointly integrates information from distinct sources. It is ideal in the context of MR-only radiotherapy planning as it can jointly regress a synthetic CT (synCT) scan and…

Computer Vision and Pattern Recognition · Computer Science 2019-08-23 Felix J. S. Bragman , Ryutaro Tanno , Zach Eaton-Rosen , Wenqi Li , David J. Hawkes , Sebastien Ourselin , Daniel C. Alexander , Jamie R. McClelland , M. Jorge Cardoso

Due to the high heterogeneity and clinical characteristics of cancer, there are significant differences in multi-omic data and clinical characteristics among different cancer subtypes. Therefore, accurate classification of cancer subtypes…

Quantitative Methods · Quantitative Biology 2023-08-23 Liangrui Pan , Dazheng Liu , Zhichao Feng , Wenjuan Liu , Shaoliang Peng

Cell classification and counting in immunohistochemical cytoplasm staining images play a pivotal role in cancer diagnosis. Weakly supervised learning is a potential method to deal with labor-intensive labeling. However, the inconstant cell…

Image and Video Processing · Electrical Eng. & Systems 2022-03-01 Shichuan Zhang , Chenglu Zhu , Honglin Li , Jiatong Cai , Lin Yang

Accurate localization of tumor regions from hematoxylin and eosin-stained whole-slide images is fundamental for translational research including spatial analysis, molecular profiling, and tissue architecture investigation. However, deep…

Computer Vision and Pattern Recognition · Computer Science 2026-03-11 Brian Isett , Rebekah Dadey , Aofei Li , Ryan C. Augustin , Kate Smith , Aatur D. Singhi , Qiangqiang Gu , Riyue Bao

Objectives To develop and validate a deep learning-based diagnostic model incorporating uncertainty estimation so as to facilitate radiologists in the preoperative differentiation of the pathological subtypes of renal cell carcinoma (RCC)…

Image and Video Processing · Electrical Eng. & Systems 2023-11-14 Ni Yao , Hang Hu , Kaicong Chen , Chen Zhao , Yuan Guo , Boya Li , Jiaofen Nan , Yanting Li , Chuang Han , Fubao Zhu , Weihua Zhou , Li Tian

The prevalence of breast cancer continues to grow, affecting about 300,000 females in the United States in 2023. However, there are different levels of severity of breast cancer requiring different treatment strategies, and hence, grading…

Computer Vision and Pattern Recognition · Computer Science 2023-08-05 Chi-en Amy Tai , Hayden Gunraj , Alexander Wong

Aim: This study investigates treatment response prediction to neoadjuvant chemotherapy (NACT) in breast cancer patients, using longitudinal contrast-enhanced magnetic resonance images (CE-MRI) and clinical data. The goal is to develop…

Image and Video Processing · Electrical Eng. & Systems 2025-12-22 Rahul Ravi , Ruizhe Li , Tarek Abdelfatah , Stephen Chan , Xin Chen

Automating tissue segmentation and tumor detection in histopathology images of colorectal cancer (CRC) is an enabler for faster diagnostic pathology workflows. At the same time it is a challenging task due to low availability of public…

Image and Video Processing · Electrical Eng. & Systems 2023-04-07 Lydia A. Schoenpflug , Maxime W. Lafarge , Anja L. Frei , Viktor H. Koelzer

Women with an increased life-time risk of breast cancer undergo supplemental annual screening MRI. We propose to predict the risk of developing breast cancer within one year based on the current MRI, with the objective of reducing screening…

Brain tumors analysis is important in timely diagnosis and effective treatment to cure patients. Tumor analysis is challenging because of tumor morphology like size, location, texture, and heteromorphic appearance in the medical images. In…

Image and Video Processing · Electrical Eng. & Systems 2022-02-14 Mirza Mumtaz Zahoor , Shahzad Ahmad Qureshi , Saddam Hussain Khan , Asifullah Khan

Accurate and automatic analysis of breast MRI plays an important role in early diagnosis and successful treatment planning for breast cancer. Due to the heterogeneity nature, accurate diagnosis of tumors remains a challenging task. In this…

Image and Video Processing · Electrical Eng. & Systems 2019-06-10 Luyang Luo , Hao Chen , Xi Wang , Qi Dou , Huangjin Lin , Juan Zhou , Gongjie Li , Pheng-Ann Heng

Mammography and ultrasound are extensively used by radiologists as complementary modalities to achieve better performance in breast cancer diagnosis. However, existing computer-aided diagnosis (CAD) systems for the breast are generally…

Image and Video Processing · Electrical Eng. & Systems 2020-09-24 Gavriel Habib , Nahum Kiryati , Miri Sklair-Levy , Anat Shalmon , Osnat Halshtok Neiman , Renata Faermann Weidenfeld , Yael Yagil , Eli Konen , Arnaldo Mayer

Predicting breast cancer recurrence risk is a critical clinical challenge. This study investigates the potential of computational pathology to stratify patients using deep learning on routine Hematoxylin and Eosin (H&E) stained whole-slide…

Computer Vision and Pattern Recognition · Computer Science 2025-12-23 Jinqiu Chen , Huyan Xu

Accurate segmentation of small lesions in Breast Dynamic Contrast-Enhanced MRI (DCE-MRI) is critical for early cancer detection, especially in high-risk patients. While recent deep learning methods have advanced lesion segmentation, they…

Computer Vision and Pattern Recognition · Computer Science 2025-08-05 Mohammed Kamran , Maria Bernathova , Raoul Varga , Christian F. Singer , Zsuzsanna Bago-Horvath , Thomas Helbich , Georg Langs , Philipp Seeböck

Breast cancer is one of the most serious types of cancer that can occur in women. The automatic diagnosis of breast cancer by analyzing histological images (HIs) is important for patients and their prognosis. The classification of HIs…

Image and Video Processing · Electrical Eng. & Systems 2022-08-02 Hayder A. Khikani , Naira Elazab , Ahmed Elgarayhi , Mohammed Elmogy , Mohammed Sallah

Deep learning models (DLMs) frequently achieve accurate segmentation and classification of tumors from medical images. However, DLMs lacking feedback on their image segmentation mechanisms, such as Dice coefficients and confidence in their…

Image and Video Processing · Electrical Eng. & Systems 2024-12-31 Elhoucine Elfatimi , Pratik Shah

Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) is a valuable tool to localize, characterize, and evaluate anomalous prostate tissue. Ultrafast gradient-echo acquisitions of MRI volumes are generated at regular time intervals…

Medical Physics · Physics 2017-10-11 Wuilian Torres , Leonardo Cordero , Miguel Martín-Landrove , Antonio Rueda-Toicen

Ki67 is an important biomarker for breast cancer. Classification of positive and negative Ki67 cells in histology slides is a common approach to determine cancer proliferation status. However, there is a lack of generalizable and accurate…

Computer Vision and Pattern Recognition · Computer Science 2018-06-29 Priya Lakshmi Narayanan , Shan E Ahmed Raza , Andrew Dodson , Barry Gusterson , Mitchell Dowsett , Yinyin Yuan