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Analysis of DNA samples is an important step in forensics, and the speed of analysis can impact investigations. Comparison of DNA sequences is based on the analysis of short tandem repeats (STRs), which are short DNA sequences of 2-5 base…

Performance · Computer Science 2018-03-07 Siddharth Samsi , Brian Helfer , Jeremy Kepner , Albert Reuther , Darrell O. Ricke

Hyperscaling of data and parameter count in LLMs is yielding diminishing improvement when weighed against training costs, underlining a growing need for more efficient finetuning and inference without sacrificing performance. This is…

Computer Vision and Pattern Recognition · Computer Science 2026-01-27 Moulik Choraria , Xinbo Wu , Akhil Bhimaraju , Nitesh Sekhar , Yue Wu , Xu Zhang , Prateek Singhal , Lav R. Varshney

Speech tokenizers are foundational to speech language models, yet existing approaches face two major challenges: (1) balancing trade-offs between encoding semantics for understanding and acoustics for reconstruction, and (2) achieving low…

Graph neural networks (GNNs), which learn the representation of a node by aggregating its neighbors, have become an effective computational tool in downstream applications. Over-smoothing is one of the key issues which limit the performance…

Machine Learning · Computer Science 2020-06-15 Kaixiong Zhou , Xiao Huang , Yuening Li , Daochen Zha , Rui Chen , Xia Hu

This paper introduces Thunder-Tok, a new Korean tokenizer designed to reduce token fertility without compromising model performance. Our approach uses a rule-based pre-tokenization method that aligns with the linguistic structure of the…

Computation and Language · Computer Science 2025-06-19 Gyeongje Cho , Yeonkyoun So , Chanwoo Park , Sangmin Lee , Sungmok Jung , Jaejin Lee

The integration of Graph Neural Networks (GNNs) with Large Language Models (LLMs) has emerged as a promising paradigm for Graph Question Answering (GraphQA). However, effective methods for encoding complex structural information into the…

Machine Learning · Computer Science 2026-04-02 Ankit Grover , Lodovico Giaretta , Rémi Bourgerie , Sarunas Girdzijauskas

Large Language Models (LLMs) demonstrate remarkable generalizability across diverse tasks, yet genomic foundation models (GFMs) still require separate finetuning for each downstream application, creating significant overhead as model sizes…

Genomics · Quantitative Biology 2025-02-07 Zehui Li , Vallijah Subasri , Yifei Shen , Dongsheng Li , Yiren Zhao , Guy-Bart Stan , Caihua Shan

Video large language models (Video-LLMs) have demonstrated strong capabilities in video understanding tasks. However, their practical deployment is still hindered by the inefficiency introduced by processing massive amounts of visual…

Computer Vision and Pattern Recognition · Computer Science 2026-05-29 Hesong Wang , Xin Jin , Lu Lu , Chenhaowen Li , Jian Chen , Qiang Liu , Huan Wang

Molecular language modeling tasks such as molecule captioning have been recognized for their potential to further understand molecular properties that can aid drug discovery or material synthesis based on chemical reactions. Unlike the…

Machine Learning · Computer Science 2025-03-12 Sangyeup Kim , Nayeon Kim , Yinhua Piao , Sun Kim

There are already many DNA large language models, but most of them still follow traditional uses, such as extracting sequence features for classification tasks. More innovative applications of large language models, such as prompt…

Genomics · Quantitative Biology 2024-10-29 Wang Liang

Neural Architecture Representation Learning aims to transform network models into feature representations for predicting network attributes, playing a crucial role in deploying and designing networks for real-world applications. Recently,…

Machine Learning · Computer Science 2025-06-10 Haizhao Jing , Haokui Zhang , Zhenhao Shang , Rong Xiao , Peng Wang , Yanning Zhang

Recent advancements in large language models (LLMs) have remarkably enhanced performances on a variety of tasks in multiple languages. However, tokenizers in LLMs trained primarily on English-centric corpora often overly fragment a text…

Computation and Language · Computer Science 2024-08-07 Jimin Hong , Gibbeum Lee , Jaewoong Cho

Domain generalization (DG) aims to improve the generalization performance for an unseen target domain by using the knowledge of multiple seen source domains. Mainstream DG methods typically assume that the domain label of each source sample…

Computer Vision and Pattern Recognition · Computer Science 2022-03-25 Chaoqi Chen , Jiongcheng Li , Xiaoguang Han , Xiaoqing Liu , Yizhou Yu

The genome sequence contains the blueprint for governing cellular processes. While the availability of genomes has vastly increased over the last decades, experimental annotation of the various functional, non-coding and regulatory elements…

Genomics · Quantitative Biology 2024-04-10 Frederikke Isa Marin , Felix Teufel , Marc Horlacher , Dennis Madsen , Dennis Pultz , Ole Winther , Wouter Boomsma

Multimodal large language models (MLLMs) have made significant advancements in vision understanding and reasoning. However, the autoregressive Transformer architecture used by MLLMs requries tokenization on input images, which limits their…

Computer Vision and Pattern Recognition · Computer Science 2026-05-05 Xiangxuan Ren , Zhongdao Wang , Liping Hou , Pin Tang , Guoqing Wang , Chao Ma

The Neural Tangent Kernel (NTK) has emerged as a powerful tool to provide memorization, optimization and generalization guarantees in deep neural networks. A line of work has studied the NTK spectrum for two-layer and deep networks with at…

Machine Learning · Statistics 2023-05-23 Simone Bombari , Mohammad Hossein Amani , Marco Mondelli

One of the challenges with finetuning pretrained language models (PLMs) is that their tokenizer is optimized for the language(s) it was pretrained on, but brittle when it comes to previously unseen variations in the data. This can for…

Computation and Language · Computer Science 2023-04-21 Verena Blaschke , Hinrich Schütze , Barbara Plank

Subword tokenization schemes are the dominant technique used in current NLP models. However, such schemes can be rigid and tokenizers built on one corpus do not adapt well to other parallel corpora. It has also been observed that in…

Computation and Language · Computer Science 2023-06-29 Makesh Narsimhan Sreedhar , Xiangpeng Wan , Yu Cheng , Junjie Hu

Machine learning (ML) is widely used today, especially through deep neural networks (DNNs), however, increasing computational load and resource requirements have led to cloud-based solutions. To address this problem, a new generation of…

Cryptography and Security · Computer Science 2025-06-23 Farzad Nikfam , Raffaele Casaburi , Alberto Marchisio , Maurizio Martina , Muhammad Shafique

Pixel-wise capabilities are essential for building interactive intelligent systems. However, pixel-wise multi-modal LLMs (MLLMs) remain difficult to scale due to complex region-level encoders, specialized segmentation decoders, and…

Computer Vision and Pattern Recognition · Computer Science 2026-01-23 Yikang Zhou , Tao Zhang , Dengxian Gong , Yuanzheng Wu , Ye Tian , Haochen Wang , Haobo Yuan , Jiacong Wang , Lu Qi , Hao Fei , Anran Wang , Zhuochen Wang , Yujing Wang , Cheng Chen , Shunping Ji , Xiangtai Li
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