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Extrachromosomal DNA (ecDNA) represents one of the most pressing challenges in cancer biology: circular DNA structures that amplify oncogenes, evade targeted therapies, and drive tumor evolution in ~30% of aggressive cancers. Despite its…

Genomics · Quantitative Biology 2026-04-09 Bryan Cheng , Jasper Zhang

Log parsing, a vital task for interpreting the vast and complex data produced within software architectures faces significant challenges in the transition from academic benchmarks to the industrial domain. Existing log parsers, while highly…

Software Engineering · Computer Science 2024-05-27 Wei Zhang , Xianfu Cheng , Yi Zhang , Jian Yang , Hongcheng Guo , Zhoujun Li , Xiaolin Yin , Xiangyuan Guan , Xu Shi , Liangfan Zheng , Bo Zhang

The Cloud-Edge continuum enhances application performance by bringing computation closer to data sources. However, it presents considerable challenges in managing resources and determining service placement, as these tasks require…

Networking and Internet Architecture · Computer Science 2026-01-27 Jacopo Massa , Valerio De Caro , Stefano Forti , Patrizio Dazzi , Davide Bacciu , Antonio Brogi

Panoptic segmentation, combining semantic and instance segmentation, stands as a cutting-edge computer vision task. Despite recent progress with deep learning models, the dynamic nature of real-world applications necessitates continual…

Computer Vision and Pattern Recognition · Computer Science 2024-04-01 Beomyoung Kim , Joonsang Yu , Sung Ju Hwang

We present EMUSE (Evolutionary Map of the Universe Search Engine), a tool designed for searching specific radio sources within the extensive datasets of the EMU (Evolutionary Map of the Universe) survey, with potential applications to other…

Design is fundamental to software development but can be demanding to perform. Thus to assist the software designer, evolutionary computing is being increasingly applied using machine-based, quantitative fitness functions to evolve software…

Software Engineering · Computer Science 2012-10-04 Christopher L. Simons , Ian C. Parmee

The operation of instruments and detectors in laboratory or beamline environments presents a complex challenge, requiring stable operation of multiple concurrent devices, often controlled by separate hardware and software solutions. These…

Inspired by natural evolutionary processes, Evolutionary Computation (EC) has established itself as a cornerstone of Artificial Intelligence. Recently, with the surge in data-intensive applications and large-scale complex systems, the…

Neural and Evolutionary Computing · Computer Science 2024-04-16 Beichen Huang , Ran Cheng , Zhuozhao Li , Yaochu Jin , Kay Chen Tan

In general Evolutionary Computation (EC) includes a number of optimization methods inspired by biological mechanisms of evolution. The methods catalogued in this area use the Darwinian principles of life evolution to produce algorithms that…

Artificial Intelligence · Computer Science 2012-04-11 José A. García Gutiérrez , Carlos Cotta , Antonio J. Fernández-Leiva

Evolutionary computing (EC) has proven to be effective in solving complex optimization and robotics problems. Unfortunately, typical Evolutionary Algorithms (EAs) are constrained by the computational capacity available to researchers. More…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-02-19 Rustam Eynaliyev , Houcen Liu

Robotic exoskeletons can enhance human strength and aid people with physical disabilities. However, designing them to ensure safety and optimal performance presents significant challenges. Developing exoskeletons should incorporate specific…

Robotics · Computer Science 2024-03-26 Baris Akbas , Huseyin Taner Yuksel , Aleyna Soylemez , Mazhar Eid Zyada , Mine Sarac , Fabio Stroppa

Visual data is used in numerous different scientific workflows ranging from remote sensing to ecology. As the amount of observation data increases, the challenge is not just to make accurate predictions but also to understand the underlying…

Computer Vision and Pattern Recognition · Computer Science 2025-02-17 Utkarsh Mall , Cheng Perng Phoo , Mia Chiquier , Bharath Hariharan , Kavita Bala , Carl Vondrick

As spatial and temporal resolutions of scientific instruments improve, the explosion in the volume of data produced is becoming a key challenge. It can be a critical bottleneck for integration between scientific instruments at the edge and…

Instrumentation and Detectors · Physics 2021-11-03 Kazutomo Yoshii , Rajesh Sankaran , Sebastian Strempfer , Maksim Levental , Mike Hammer , Antonino Miceli

One of the primary science goals of the Large UV/Optical/Infrared Surveyor (LUVOIR) mission concept is to detect and characterize Earth-like exoplanets orbiting nearby stars with direct imaging. The success of its coronagraph instrument…

Instrumentation and Methods for Astrophysics · Physics 2021-08-17 Axel Potier , Garreth Ruane , Pin Chen , Ankur Chopra , Larry Dewell , Roser Juanola-Parramon , Alison Nordt , Laurent Pueyo , David Redding , A. J. Eldorado Riggs , Dan Sirbu

Evolutionary computation is an important component within various fields such as artificial intelligence research, reinforcement learning, robotics, industrial automation and/or optimization, engineering design, etc. Considering the…

Neural and Evolutionary Computing · Computer Science 2023-05-23 Nihat Engin Toklu , Timothy Atkinson , Vojtěch Micka , Paweł Liskowski , Rupesh Kumar Srivastava

Analog circuit design is a time-consuming, experience-driven task in chip development. Despite advances in AI, developing universal, fast, and stable gate sizing methods for analog circuits remains a significant challenge. Recent approaches…

Artificial Intelligence · Computer Science 2025-08-08 Xinyue Wu , Fan Hu , Shaik Jani Babu , Yi Zhao , Xinfei Guo

The challenge of optimal design of experiments (DOE) pervades materials science, physics, chemistry, and biology. Bayesian optimization has been used to address this challenge in vast sample spaces, although it requires framing experimental…

Recent progress in diffusion-based generative models has enabled high-quality image synthesis conditioned on diverse modalities. Extending such models to brain signals could deepen our understanding of human perception and mental…

Signal Processing · Electrical Eng. & Systems 2025-11-25 Jeyoung Lee , Hochul Kang

Computer models are used as replacements for physical experiments in a large variety of applications. Nevertheless, direct use of the computer model for the ultimate scientific objective is often limited by the complexity and cost of the…

Methodology · Statistics 2019-07-03 Sonja Surjanovic , William J. Welch
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