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Information retrieval (IR) methods for KGQA consist of two stages: subgraph extraction and answer reasoning. We argue current subgraph extraction methods underestimate the importance of structural dependencies among evidence facts. We…

Computation and Language · Computer Science 2024-02-06 Wentao Ding , Jinmao Li , Liangchuan Luo , Yuzhong Qu

Research in Machine Learning (ML) and AI evolves rapidly. Information Extraction (IE) from scientific publications enables to identify information about research concepts and resources on a large scale and therefore is a pathway to improve…

Computation and Language · Computer Science 2025-11-13 Wolfgang Otto , Lu Gan , Sharmila Upadhyaya , Saurav Karmakar , Stefan Dietze

The rapid advancement of large language models (LLMs) has opened new boundaries in the extraction and synthesis of medical knowledge, particularly within evidence synthesis. This paper reviews the state-of-the-art applications of LLMs in…

A common thread of open-domain question answering (QA) models employs a retriever-reader pipeline that first retrieves a handful of relevant passages from Wikipedia and then peruses the passages to produce an answer. However, even…

Computation and Language · Computer Science 2022-10-11 Mingxuan Ju , Wenhao Yu , Tong Zhao , Chuxu Zhang , Yanfang Ye

We introduce an explainability method for biomedical hypothesis generation systems, built on top of the novel Hypothesis Generation Context Retriever framework. Our approach combines semantic graph-based retrieval and relevant…

Information Retrieval · Computer Science 2025-11-11 Ilya Tyagin , Saeideh Valipour , Aliaksandra Sikirzhytskaya , Michael Shtutman , Ilya Safro

Pursuing artificial intelligence for biomedical science, a.k.a. AI Scientist, draws increasing attention, where one common approach is to build a copilot agent driven by Large Language Models (LLMs). However, to evaluate such systems,…

Computation and Language · Computer Science 2024-07-02 Xinna Lin , Siqi Ma , Junjie Shan , Xiaojing Zhang , Shell Xu Hu , Tiannan Guo , Stan Z. Li , Kaicheng Yu

With the increasing use of large language models (LLMs) for generating answers to biomedical questions, it is crucial to evaluate the quality of the generated answers and the references provided to support the facts in the generated…

Computation and Language · Computer Science 2026-02-10 Deepak Gupta , Davis Bartels , Dina Demner-Fushman

Understanding protein structure and function is crucial in biology. However, current computational methods are often task-specific and resource-intensive. To address this, we propose zero-shot Protein Question Answering (PQA), a task…

Machine Learning · Computer Science 2024-11-20 Eli M Carrami , Sahand Sharifzadeh

Electronic Health Records (EHRs) hold immense potential for advancing healthcare, offering rich, longitudinal data that combines structured information with valuable insights from unstructured clinical notes. However, the unstructured…

Computation and Language · Computer Science 2025-01-31 Huaiyuan Ying , Hongyi Yuan , Jinsen Lu , Zitian Qu , Yang Zhao , Zhengyun Zhao , Isaac Kohane , Tianxi Cai , Sheng Yu

Despite strong performance in medical question-answering, the clinical adoption of Large Language Models (LLMs) is critically hampered by their opaque 'black-box' reasoning, limiting clinician trust. This challenge is compounded by the…

Computer Vision and Pattern Recognition · Computer Science 2025-05-13 Chao Ding , Mouxiao Bian , Pengcheng Chen , Hongliang Zhang , Tianbin Li , Lihao Liu , Jiayuan Chen , Zhuoran Li , Yabei Zhong , Yongqi Liu , Haiqing Huang , Dongming Shan , Junjun He , Jie Xu

Biomedical question answering (QA) requires accurate interpretation of complex medical knowledge. Large language models (LLMs) have shown promising capabilities in this domain, with retrieval-augmented generation (RAG) systems enhancing…

Computation and Language · Computer Science 2025-10-21 Yingpeng Ning , Yuanyuan Sun , Ling Luo , Yanhua Wang , Yuchen Pan , Hongfei Lin

Electronic health records (EHRs) form an invaluable resource for training clinical decision support systems. To leverage the potential of such systems in high-risk applications, we need large, structured tabular datasets on which we can…

Artificial Intelligence · Computer Science 2025-11-24 Paloma Rabaey , Adrick Tench , Stefan Heytens , Thomas Demeester

Increasing clinical trial protocol complexity, amendments, and challenges around knowledge management create significant burden for trial teams. Structuring protocol content into standard formats has the potential to improve efficiency,…

Information Retrieval · Computer Science 2026-04-20 Ramtin Babaeipour , François Charest , Madison Wright

Motivation: Biomedical knowledge graphs (KGs) are crucial for drug discovery and disease understanding, yet their completion and reasoning are challenging. Knowledge Embedding (KE) methods capture global semantics but struggle with dynamic…

Artificial Intelligence · Computer Science 2025-07-23 Yitong Lin , Jiaying He , Jiahe Chen , Xinnan Zhu , Jianwei Zheng , Tao Bo

Keyphrase generation is the task consisting in generating a set of words or phrases that highlight the main topics of a document. There are few datasets for keyphrase generation in the biomedical domain and they do not meet the expectations…

Computation and Language · Computer Science 2022-11-23 Mael Houbre , Florian Boudin , Beatrice Daille

Biomedical Information Extraction is an exciting field at the crossroads of Natural Language Processing, Biology and Medicine. It encompasses a variety of different tasks that require application of state-of-the-art NLP techniques, such as…

Computation and Language · Computer Science 2017-05-17 Surag Nair

Large Language Models (LLMs) excel in many natural language processing tasks but often exhibit factual inconsistencies in knowledge-intensive settings. Integrating external knowledge resources, particularly knowledge graphs (KGs), provides…

Computation and Language · Computer Science 2026-02-17 Shuai Wang , Yinan Yu

Biomedical reasoning integrates structured, codified knowledge with tacit, experience-driven insights. Depending on the context, quantity, and nature of available evidence, researchers and clinicians use diverse strategies, including…

Artificial Intelligence · Computer Science 2025-03-04 Xiaorui Su , Yibo Wang , Shanghua Gao , Xiaolong Liu , Valentina Giunchiglia , Djork-Arné Clevert , Marinka Zitnik

Longitudinal datasets measured repeatedly over time from individual subjects, arise in many biomedical, psychological, social, and other studies. A common approach to analyse high-dimensional data that contains missing values is to learn a…

Machine Learning · Statistics 2021-04-21 Siddharth Ramchandran , Gleb Tikhonov , Kalle Kujanpää , Miika Koskinen , Harri Lähdesmäki

A key challenge of multi-hop question answering (QA) in the open-domain setting is to accurately retrieve the supporting passages from a large corpus. Existing work on open-domain QA typically relies on off-the-shelf information retrieval…

Computation and Language · Computer Science 2019-11-05 Wenhan Xiong , Mo Yu , Xiaoxiao Guo , Hong Wang , Shiyu Chang , Murray Campbell , William Yang Wang